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Pharmacology Equations > Oncogenes > Flashcards

Oncogenes Flashcards

1
Q

SIS

A

PDGF-B chain
Overexpression
Astrocytoma
Osteosarcoma

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2
Q

HST-1

A

FGF
Overexpression
Stomach Cancer

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3
Q

INT-2

A

FGF
Amplification
Bladder, Breast, and Melanoma

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4
Q

TGF-a

A

TGF-a
Overexpression
Astrocytoma and Hepatocellular Carcinoma

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5
Q

HGF

A

HGF
Overexpression
Thyroid Cancer

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6
Q

ERB-B1

A

Overexpression

Squamous cell carcinoma of lung

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7
Q

ERB-B2

A

Amplification

Breast and ovarian cancers

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8
Q

FMS

A

Point mutation

Leukemia

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9
Q

RET

A

Point Mutation

Familial Medullary thyroid carcinoma

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10
Q

PDGF-R

A

Overexpression

Gliomas

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11
Q

KiT

A

Point Mutation

Gastrointestinal soft tissue tumors

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12
Q

K-RAS

A

Point Mutation

Colon, lung, and pancreatic tumors

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13
Q

H-RAS

A

Point Mutation

Bladder and Kidney Tumors

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14
Q

N-RAS

A

Point Mutation

Melanomas, hematologic cancers

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15
Q

ABL

A

Translocation
CML, ALL
Complexes with BCR
Imatinib is potent therapeutic

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16
Q

BRAF

A

Point Mutation

Melanomas

17
Q

B-catenin

A

Point Mutation and Overexpression

Hepatoblastomas, hepatocellular carcinoma

18
Q

C-Myc

A 
Translocation
Burkitt Lymphoma (8:14)
19
Q

N-Myc

A

Amplification

Neuroblastoma, small cell carcinoma of lung

20
Q

L-Myc

A

Amplification

Small cell carcinoma of lung

21
Q

Cyclin D

A

Translocation: Mantle Cell lymphoma
Amplification: Breast and esophageal cancer

22
Q

Cyclin E

A

Overexpression

Breast Cancer

23
Q

CDK4

A

Amplification or Point Mutation

Glioblastoma, melanoma, sarcoma

24
Q

Mechanism of P53 action

A

ATM and ATR phosphorylate MDM2 which is normally bound to p53
p53 then acts as a transcription factor for other genes that arrest the cell cycle like p21
If DNA is repaired MDM2 is upregulated and p53 is bound again and degraded
If no repair p53 activated cell senescence through E2F pathway or apoptosis via activation of caspases

Pharmacology Equations (8 decks)

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