Last Minute Stuff Flashcards by Brett Monson

Aliphatic hydroxylation

Ibuprofen, pentobarbital, cyclosporine

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Aromatic hydroxylation

phenytoin, propanolol, steroids

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N-Dealkylation

imipramine, diazepam, codeine, morphine, tamoxifen, caffeine

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N oxidation

chlorpheniamine, trimethylamine

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S oxidation

chlorpromzine, cimetidine

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1A2

acetaminophen
caffeine
theophylline
warfarin

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2A6

zidovudine, warfarin

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2C9

phenytoin
S-warfarin
hexobarbital
ibuprofen

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2C19

diazepam
omeprazole
propanolol

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2D6

amitriptyline
fluoxetine
timolol
codeine, hydrocodone

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2E1

acetaminophen

ethanol

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3A4

50%

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Hydrolysis (non p450)

aspirin

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Glucuronidation

acetaminophen, morphine, imipramine, cloxapine

UDP-Gluc transferases

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Sulfation

ethanol

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acetylation

procainamide
isoniazid
sulfanilimide
histamine

Why not to drink with acetaminophen

More induced CYP2e1 leads to production of toxid NAPQI via the minor route

Drugs with high index of suspicion for interactions

Anti seizure drugs
protease inhibitors
statins
warfarin
digoxin