Last Minute Stuff Flashcards

1
Q

Aliphatic hydroxylation

A

Ibuprofen, pentobarbital, cyclosporine

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2
Q

Aromatic hydroxylation

A

phenytoin, propanolol, steroids

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3
Q

N-Dealkylation

A

imipramine, diazepam, codeine, morphine, tamoxifen, caffeine

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4
Q

N oxidation

A

chlorpheniamine, trimethylamine

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5
Q

S oxidation

A

chlorpromzine, cimetidine

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6
Q

1A2

A

acetaminophen
caffeine
theophylline
warfarin

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7
Q

2A6

A

zidovudine, warfarin

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8
Q

2C9

A

phenytoin
S-warfarin
hexobarbital
ibuprofen

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9
Q

2C19

A

diazepam
omeprazole
propanolol

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10
Q

2D6

A

amitriptyline
fluoxetine
timolol
codeine, hydrocodone

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11
Q

2E1

A

acetaminophen

ethanol

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12
Q

3A4

A

50%

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13
Q

Hydrolysis (non p450)

A

aspirin

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14
Q

Glucuronidation

A

acetaminophen, morphine, imipramine, cloxapine

UDP-Gluc transferases

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15
Q

Sulfation

A

ethanol

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16
Q

acetylation

A

procainamide
isoniazid
sulfanilimide
histamine

17
Q

Why not to drink with acetaminophen

A

More induced CYP2e1 leads to production of toxid NAPQI via the minor route

18
Q

Drugs with high index of suspicion for interactions

A
Anti seizure drugs
protease inhibitors
statins
warfarin
digoxin