Oncogenes

Question 1

BCL-ABL

Answer 1

Associated Tumor: CML, ALL

Gene Product: Tyrosine Kinase

Question 2

bcl-2

Answer 2

Associated Tumor: Follicular and undifferentiated Lymphomas

Gene Product: Anti-apoptotic molecule

Question 3

BRAF

Answer 3

Associated Tumor: Melanoma

Gene Product: Serine/Threonine Kinase

Question 4

c-kit

Answer 4

Associated Tumor: Gastrointestinal Stromal Tumor (GIST)

Gene Product: Cytokine receptor for stem cell factor

Question 5

c-myc

Answer 5

Associated Tumor: Burkitt Lymphoma

Gene Product: Transcription Factor

Question 6

HER2/ neu (c-erbB2)

Answer 6

Associated Tumor: Breast, ovarian and Gastric Carcinoma

Gene Product: Tyrosine Kinase

Question 7

L-myc

Answer 7

Associated Tumor: Lung Tumor

Gene Product: Transcription Factor

Question 8

N-myc

Answer 8

Associated Tumor: Neuroblastoma

Gene Product: Transcription Factor

Question 9

ras

Answer 9

Associated Tumor: Colon, Lung, and Pancreatic Cancer

Gene Product: GTPase

Question 10

ret

Answer 10

Associated Tumor: MEN 2A and 2B

Gene Product: Tyrosine Kinase

Question 11

Describe an oncogene

Answer 11

Gain of function results in increased cancer risk.

***Need damage to only 1 allele