Onco/Hema

Question 0

BM findings in ALL

Answer 0

> 25% of BM cells as a homogenous population of lymphoblasts

Question 1

Phases of treatment of ALL

Answer 1

Remission induction - 4 weeks
Consolidation phase - 14-28 weeks
Maintenance phase - 2-3 years

Question 2

Remission in ALL

Answer 2

< 5% blasts in BM and return of platelet and neutrophil count to near normal levels

Question 3

Sites of relapse for ALL

Answer 3

Bone marrow

CNS, testes - sanctuary sites

Question 4

Staging classification for Lymphomas

Answer 4

Ann Arbor Staging Claasification

Question 5

B symptoms important in staging lymphoma

Answer 5

Weight loss > 10% of TBW over 3 months
Unexplained high fever
Drenching night sweats

Question 6

Reed sternberg cells

Answer 6

Hodgkin’s lymphoma

Question 7

Which with more extra nodal involvement - Hodgkins or Non-Hodgkins

Answer 7

Non-Hodgkins

Question 8

Tx for Hodgkins

Answer 8

COPAD
Cyclophosphamide
Vincristine
Prednisone
Doxorubicin

Question 9

MC subtype of NHL

Answer 9

Burkitt lymphoma (40%)

Question 10

Wilms tumor - crosses the midline or not?

Answer 10

No. Does not cross the midline

Wan side lang

Question 11

Painless abdominal pain with flank mass that does not cross the midline in a 3 year old

Answer 11

Wilms tumor

Question 12

Median age of diagnosis of Neuroblastoma

Answer 12

2 years old

Question 13

Gene associated with Neuroblastoma

Answer 13

N-myc

Question 14

Opsoclonus/ myoclonus

Answer 14

Neuroblastoma

Question 15

Dancing eyes, dancing feet

Answer 15

Neuroblastoma

Question 16

Dx tests for Neuroblastoma

Answer 16

Abdominal CT scan

24- hr urine VMA and HVA (?)

Question 17

Most common soft tissue sarcoma in children

Answer 17

Rhabdomyosarcoma

Question 18

Worst histologic subtype of rhabdomyosarcoma

Answer 18

Alveolar

Question 19

Vaginal grape-like mass - type of rhabdomyosarcoma

Answer 19

Sarcoma botryoides

Question 20

Highest risk period for development of osteosarcoma

Answer 20

Adolescent growth spurt

Question 21

Deep bone pain causing nighttime awakening

Answer 21

Osteosarcoma

Question 22

X-ray finding in osteosarcoma

Answer 22

Sunburst pattern

Due to mineralization and formation of periosteal spicules in the surrounding tissue

Question 23

Moth eaten lytic lesion on X-ray

Answer 23

Ewing sarcoma

Question 24

Origin of Ewing sarcoma

Answer 24

Neural crest

Question 25

Ewing sarcoma arising from the chest wall

Answer 25

Askin tumors

Question 26

MC chromosomal aberration of Ewing sarcoma

Answer 26

t(11;22) translocation

Question 27

Classic X-ray finding of Ewing sarcoma

Answer 27

Onion skinning or moth eaten appearance

Question 28

Location of osteosarcoma in bone

Answer 28

Metaphyses of long bones

Question 29

Location of Ewing sarcoma on bone

Answer 29

Diaphysis of long bones

Question 30

Age group most commonly affected with iron deficiency anemia

Answer 30

6-24 months old

Question 31

Most important sign of IDA

Answer 31

Pallor

Question 32

Spoon nails

Answer 32

Aka koilonychia

Seen in patients with IDA

Question 33

TIBC in IDA and Anemia of Chronic Diseaae

Answer 33

IDA: high TIBC
ACD: low TIBC

Question 34

Definitive diagnostic test for Thalassemia

Answer 34

Hb electrophoresis