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Pedia > Onco/Hema > Flashcards

Onco/Hema Flashcards

0
Q

BM findings in ALL

A

> 25% of BM cells as a homogenous population of lymphoblasts

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1
Q

Phases of treatment of ALL

A

Remission induction - 4 weeks
Consolidation phase - 14-28 weeks
Maintenance phase - 2-3 years

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2
Q

Remission in ALL

A

< 5% blasts in BM and return of platelet and neutrophil count to near normal levels

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3
Q

Sites of relapse for ALL

A

Bone marrow

CNS, testes - sanctuary sites

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4
Q

Staging classification for Lymphomas

A

Ann Arbor Staging Claasification

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5
Q

B symptoms important in staging lymphoma

A

Weight loss > 10% of TBW over 3 months
Unexplained high fever
Drenching night sweats

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6
Q

Reed sternberg cells

A

Hodgkin’s lymphoma

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7
Q

Which with more extra nodal involvement - Hodgkins or Non-Hodgkins

A

Non-Hodgkins

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8
Q

Tx for Hodgkins

A 
COPAD
Cyclophosphamide
Vincristine
Prednisone
Doxorubicin
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9
Q

MC subtype of NHL

A

Burkitt lymphoma (40%)

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10
Q

Wilms tumor - crosses the midline or not?

A

No. Does not cross the midline

Wan side lang

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11
Q

Painless abdominal pain with flank mass that does not cross the midline in a 3 year old

A

Wilms tumor

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12
Q

Median age of diagnosis of Neuroblastoma

A

2 years old

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13
Q

Gene associated with Neuroblastoma

A

N-myc

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14
Q

Opsoclonus/ myoclonus

A

Neuroblastoma

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15
Q

Dancing eyes, dancing feet

A

Neuroblastoma

16
Q

Dx tests for Neuroblastoma

A

Abdominal CT scan

24- hr urine VMA and HVA (?)

17
Q

Most common soft tissue sarcoma in children

A

Rhabdomyosarcoma

18
Q

Worst histologic subtype of rhabdomyosarcoma

A

Alveolar

19
Q

Vaginal grape-like mass - type of rhabdomyosarcoma

A

Sarcoma botryoides

20
Q

Highest risk period for development of osteosarcoma

A

Adolescent growth spurt

21
Q

Deep bone pain causing nighttime awakening

A

Osteosarcoma

22
Q

X-ray finding in osteosarcoma

A

Sunburst pattern

Due to mineralization and formation of periosteal spicules in the surrounding tissue

23
Q

Moth eaten lytic lesion on X-ray

A

Ewing sarcoma

24
Q

Origin of Ewing sarcoma

A

Neural crest

25
Q

Ewing sarcoma arising from the chest wall

A

Askin tumors

26
Q

MC chromosomal aberration of Ewing sarcoma

A

t(11;22) translocation

27
Q

Classic X-ray finding of Ewing sarcoma

A

Onion skinning or moth eaten appearance

28
Q

Location of osteosarcoma in bone

A

Metaphyses of long bones

29
Q

Location of Ewing sarcoma on bone

A

Diaphysis of long bones

30
Q

Age group most commonly affected with iron deficiency anemia

A

6-24 months old

31
Q

Most important sign of IDA

A

Pallor

32
Q

Spoon nails

A

Aka koilonychia

Seen in patients with IDA

33
Q

TIBC in IDA and Anemia of Chronic Diseaae

A

IDA: high TIBC
ACD: low TIBC

34
Q

Definitive diagnostic test for Thalassemia

A

Hb electrophoresis

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