OME endocrine

Question 1

tx for graves dz

Answer 1

PTU or methimazole

Question 2

tx for thyroid storm

Answer 2

propranolol, PTU, steroids

Question 3

causes of cushing syndrome (4)

Answer 3

ACTH: pituitary vs ectopic, iatrogenic, adrenal tumor

Question 4

cushing syndrome initial test

Answer 4

no suppression w/ low dose dex supp test

+ late night salivary cortisol OR 24hr urine

Question 5

cushing syndrome w/ nml ACTH

Answer 5

primary hypercortisolism (adrenal tumor)

Question 6

cushing syndrome w/ high ACTH

Answer 6

high dose dex supp test

• fails = ectopic
• suppressed = cushing dz

Question 7

acute presentation hypocortisolism: BP, etc

Answer 7

hTN, N/V, coma

Question 8

chronic presentation addisons: BP, Na, K

Answer 8

hTN, low Na, high K

Question 9

addisons initial test

Answer 9

AM cortisol = low

Question 10

addisons secondary test

Answer 10

cosyntropin stim test
inc cortisol = ant pituitary
no change = adrenal -> image

Question 11

tx for addisons

Answer 11

cortisol + fludrocortisone (if adrenal)

Question 12

HTN + hypokalemia

Answer 12

Conn’s syndrome (hyperaldo)

Question 13

aldo:renin <10

Answer 13

renovascular

Question 14

aldo:renin >30

Answer 14

conn’s syndrome

Question 15

HA, HTN, palpitations, sweating

Answer 15

pheo

Question 16

metformin side effects

Answer 16

• diarrhea

- lactic acidosis in CHF, CKD

Question 17

glypizide MOA, side effects

Answer 17

sulfonylurea - inc insulin release

SE: hypoglycemia

Question 18

glitazone side effects

Answer 18

weight gain, CHF

Question 19

-gliptins MOA, side effects

Answer 19

DDP4-i (DDP4 breaks down GLP1), weight neutral

Question 20

-glutides MOA, side effects

Answer 20

GLP1-a, weight loss

Question 21

-glifozin MOA, side effects

Answer 21

SGLT2-i (kidney glu absorption) -> promote glu excretion

SE: GU, dehydration