Omalizumab

Question 1

What is it?

Answer 1

Monoclonal antiody that binds to IgE

Question 2

Use

Answer 2

Add on treatment
- Severe, persistent allergic asthma (6+)
- Chronic spontaneous urticaria (12+)

Question 3

Severe, persistent allergic asthma (6+)

Answer 3

Inadequate response to high dose ICS with LABA who need frequent oral corticosteroids (>4 courses in last year)

Question 4

Chronic spontaneous urticaria (12+)

Answer 4

Inadequate response to H1 antihistamines + LTRA

Question 5

Side effects

Answer 5

Hypersensitivity reactions
Churg-Strauss syndrome (associated with reduction of oral corticosteroids)