Old Quiz 1 Questions

Question 1

In virology, what is meant by the term nonstructural protein?

Answer 1

a protein that is encoded for by the virus but is only found in the infected host cell. Not part of the virus particle.

Question 2

What two functions are invariably associated with the proteins encoded by any given virus?

Answer 2

• genome protection

- genome replication

Question 3

In what class of single-stranded RNA viruses is the RdRp always a structural protein?

Answer 3

• negative sense single stranded RNA

Question 4

What are two distinct post-transcriptional modifications that may occur during the maturation of mRNA molecules in eukaryotic cells?

Answer 4

• intron/exon splicing
• the addition of a 7methylGTP cap attached 5’ to 5’ to the end of the primary transcript
• poly A additional signal leading to the poly A tail. The termination sequence is found on the RNA signal and the signal is recognized and cleavage occurs downstream of the signal. A new 3’ end is created and this is where the primary transcript is polyadenylated.

Question 5

What two kinds of macromolecules do extracellular virus particles invariably contain?

Answer 5

• nucleic acid (genetic material)

- protein (aids in protection of the genetic material and attachment of the virus particle to the host cell)

Question 6

In the NdNp notation, what is the designation of reverse transcriptase activity?

Answer 6

-RdDp

Question 7

In virology, what specifically is meant by the term structural protein?

Answer 7

• protein that is part of the virus particle

Question 8

What are two different kids of virus coded proteins that may be involved in genetic replication?

Answer 8

• nucleic acid polymerase
• modifier subunit - hijacks the cellular polymerase. Cell can no longer replicate its own genome. Can only replace the viral genome

Question 9

What types of virus encode ribosomal RNA molecules?

Answer 9

none