Old Age Psych Flashcards
What is the ABCD of dementia that makes dementia a clinical syndrome?
A for Activities of Daily Living (ADLs)
B for Behavioural and Psychiatric Symptoms of Dementia (BPSD)
C for Cognitive Impairment
D for Decline
What is the duration of dementia and what is the diagnosis based on?
6 months duration, usually progressive
Diagnosis based on Hx and collateral
Why is a diagnosis of dementia deferred in delirium?
Because it’s very difficult to know how a person is functioning at their baseline when there’s a superimposed delirium.
What is looked for and tested in dementia?
PMHx & Medication (particularly anti cholinergics)
Cognitive testing with emphasis on relevant lobes-Neuropsychology
Physical examination & bloods
Supportive evidence from brain imaging
What are the cognitive features of dementia?
Memory (dysmnesia)
Plus one or more of:
dysphasia (communication)
- expressive
- receptive
dyspraxia (inability to carry out motor skills)
dysgnosia (not recognising objects)
dysexecutive functioning (initiation, inhibition, set-shifting, abstraction)
What are important areas to ask about in functional impairment?
ADL
Driving
Meds
Finances
Communication
Are those with dementia or organic brain syndrome still fit to drive?
Notify DVLA at diagnosis
If early dementia license may be yearly
“those with poor short term memory, disorientation or lack of insight should almost certainly not drive”
What mental state examinations are available?
MMSE
MOCA-can be useful in showing a deterioration from baseline score
What can a DAT scan be used for?
LBD
Parkinsons
How is AD diagnosed in primary care (systematic approach)?
A structured and systematic approach is required to ensure the early diagnosis and management of AD. The diagnostic process includes:
Case-finding (symptoms suggestive of cognitive impairment)
Clinical assessment (clinical Hx & collateral Hx, MSE, physical & bloods, cog assessment)
Differentiating AD from other causes of dementia (functional decline & cog impairment-exclude delirium, depression and other causes of ‘dementia’)
Management of AD
- Confirm diagnosis-brain scanning or neuropsychology
- Management & symptomatic treatment
- Follow-up
What is the aetiology of dementia?
Alzheimer’s dementia – 62%
Vascular dementia – 17%
Mixed Dementia – 10%
Lewy body dementia – 4%
Frontotemporal (Picks) (behavioural, PNFA: progressive non fluent aphasia, semantic)
Alcohol; ARBD (alcohol dementia/ Korsakoffs (thiamine deficiency))
Subcortical - Parkinson’s, Huntington’s, HIV
Prion Protein eg CJD
What are some examples of ‘reversible causes of dementia?
Hypercalcaemia – abdominal pain, bone pain, kidney stones, depression and confusion
Normal pressure hydrocephalus=triad of memory difficulties, urinary changes and gait disturbances
Vit B12 deficiency
Hypothyroidism
SDH
What are the symptoms and signs of AD?
Early impairment of memory and executive function
Gradual progression with often unclear onset
Main features:
Amyloid plaques & tau tangles
Atrophy following neuron death
Reduction in Acetylcholine
What scans could be used to differentiate dementias?
SPECT
PET scan might be more sensitive in younger people
What lobes in particular are affected in alzheimer’s?
Temporal lobes
What are the characteristic signs of vascular dementia?
Unequal distribution of deficits
Evidence of focal impairments on neuro exam
Evidence of cerebrovascular disease - PMHx
STEP WISE DECLINE with sudden changes
Small vessel disease can give gradual decline
What are the key features of Lewy Body Dementia?
Visual hallucinations
Fluctuations
Parkinsonism
What present features would support a diagnosis of LBD?
Sensitivity to antipsychotics
Reduced dopamine uptake on SPECT or PET scan
Increased falls
REM sleep disorder
What questionnaire is used to identify symptoms of Dementia with Lewy bodies?
DIAMOND
What is the sensitivity and specificity of a DAT scan for DLB & what sign is shown on the scan?
Around 85%
The DAT Scan on a normal or AD patient will show normal re-uptake of the dopamine transporter in the head of the caudate nucleus and putamen in the shape of a ‘comma’, whereas in DLB, re-uptake in the putamen is reduced, leading to the ‘full-stop’ sign.
What is the sensitivity and specificity of a DAT scan for DLB & what sign is shown on the scan?
Around 85%
The DAT Scan on a normal or AD patient will show normal re-uptake of the dopamine transporter in the head of the caudate nucleus and putamen in the shape of a ‘comma’, whereas in DLB, re-uptake in the putamen is reduced, leading to the ‘full-stop’ sign.
What can be seen on an MRI image of Pick’s disease (frontotemporal dementia)?
Note the difference in the gyro thickness and size of the sulci between the frontotemporal region and the parietal/occipital region
FTD (frontotemporal dementia) what are the signs of it?
Behavioural disorder – personality change
Can be early onset
Early emotional blunting
Speech disorder - altered output, stereotypy, echolalia, perseveration, mutism
Neuropsychology - frontal dysexecutive syndrome. Memory, praxis and visuospatial function not severely impaired
Neuroimaging - abnormalities in frontotemporal lobes
Neurological signs commonly absent early; parkinsonism later; MND in a few; autonomic; incontinence; primitive reflexes
What behavioural & psychological symptoms are present in dementia?
Agitation (Restlessness, Wandering)
Psychosis (Delusions, Hallucinations)
Affective (Depression, Anxiety, Lability, Hypomania, Apathy)
Disinhibition (Aggression, Sexual)
Behaviour (Eating, toileting, dressing, Sleep-wake cycle)