Oesophageal and Gastric Pathology Flashcards
Where is the gestrooesophageal junction?
At the end of the rugae in the proximal stomach = start of oesophagus.
What sort of epithelium is the oesophagus?
Non-keratinising squamous epithelium.
What are the major forms of oesophageal metaplasia?
Reflux acid = glandular metaplasia
Reflux bile = intestinal metaplasia
What is the average distance to squamo-columnar junction?
40cm from teeth to squamocolumnar junction (i.e. gastrooesophageal junction).
What is eosinophilic oesophagitis?
Young, male>females; generally atopic.
Eosinophils invade –> inflammation.
May present with dysphagia.
What is the histopathology of GORD?
Hyperaemia; esoniophils; neutrophils.
Basal layer hyperplasia, elongation of CT, papillae.
What are the complications of GORD?
Ulceration, Barrets oesophagus.
What are the microscopic features of eosinophilic oesophagitis?
> 20 eosinophils per high power field.
Rx eosinophilic oesphagitis?
Remove triggers, cromoglycate, steroid.
What are the risk factors for oesophageal malignancies?
EtOH, tobacco use, caustic burns, achalasia etc. –> Squamous cell carcinoma.
Barrett’s Oesophagous –> adenocarcinoma
Which markers are used for oesophageal dysphasia?
p53 and Ki67 expression increase with grade of dysplasia
How does p53 expression vary in inflammatory conditions?
p53 expression doesn’t really change in inflammatory conditions
