Liver Pathology

Question 1

What are the features of alcoholic steatohepatitis?

Answer 1

Generally unwell, low fever, tender hepatomegaly, often icteric, +/- N/V/D, ALT/AST may be greatly elevated.

Question 2

Why is GGT elevated in steatohepatitis?

Answer 2

Hepatocellular ballooning compressing bile ducts.

Alcohol also induce biliary cells in bile ducts to produce GGT.

Question 3

What is NASH?

Answer 3

Histologically similar to ASH but often less severe. Hepatic manifestation of metabolic syndrome.
? Greatest cause idiopathic cirrhosis

Question 4

What are the common malignant liver neoplasms?

Answer 4

• Hepatocellular carcinoma
• Cholangiocarcinoma
• Angiosarcoma

Question 5

What is the commonest liver neoplasm?

Answer 5

Metastases

Question 6

What are the features of hepatocellular carcinoma?

Answer 6

-Abnormal architecture: trabeculae >3 cell thick, acini; abnormal bile canalicular architecture.

Question 7

What is the aetiology of HCC?

Answer 7

HBC, HCV, EtOH, aflatoxin, membranous IVC obstruction, haemochromatosis, tyrosinemia.