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Oral medicine > Odontogenic tumors > Flashcards

Odontogenic tumors Flashcards

1
Q

name the cardinal histologic features of odontogenic epithelium (4)

A
  • palisading of the basilar epithelium
  • palisading epithelial cells have antibasilar nuclei
  • palisading cells have a basilar clear zone within the cytoplasm
  • centrally, odontogenic islands are comprised of polygonal cells with long intracellular desmosomal bridges reminiscent of the stellate reticulum
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2
Q

which of the 4 cardinal histologic features of odontogenic epithelium is absent in CAA?

A

stellate reticulum-like cells

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3
Q

what are the 4 architecture arrangements of odontogenic epithelium?

A
  • plexiform ribbons
  • round follicles
  • anastomosing trabeculae
  • ink drop structures
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4
Q

which architecture arrangement of epithelium is pathognomonic for odontogenic epithelium?

A

ink drop structures

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5
Q

what is required to produce mineralized dental matrix in a tumor?

A

an odontoblastic component
(because of the process of reciprocal induction, there must be ameloblasts to signal odontoblasts to make dentin which in turn signal ameloblasts to make enamel).

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6
Q

what does the term ‘‘odonto’’ imply in a tumor name?

A

the tumor has mineralized dental matrix (thus an odontoblastic component)

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7
Q

what does the term ‘‘fibro’’ imply in a tumor name?

A

derived from the dental papilla

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8
Q

what is a mixed tumor?

A

when the neoplastic odontogenic epithelium is capable is capable of inducing the develpoment of dental papilla-like ectomesenchyme

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9
Q

how does a pathologist determine what the umor type is?

A

first by identifying if odontogenic epithelium is present. Then by identifiying if there is a component of either dental papilla derived tissues, mineralized dental matrices or dental follicule derived tissues.

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10
Q

what odontogenic tumors present with odontogenic induction?

A 
ameloblastic fibroma
feline inductive odontogenic tumor
ameloblastic fibro-odontoma
odontoameloblastoma
odontoma
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11
Q

which odontogenic tumors lack odontogenic induction?

A 
POF
conventional ameloblastoma
CAA
Amyloid producting ameloblastoma
odontogenic myxoma
cementoblastoma
nodular hypercementosis
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12
Q

what are the malignant odontogenic tumors?

A 
ameloblastic fibro-odontoma 
ameloblastic fibrosarcoma
ameloblastic carcinoma
Odontogenic myxoma
primary intraosseous squamous cell carcinoma (wiggs)
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13
Q

What is the other name for amyloid-producing ameloblastoma?

A

amyloid-producing odontogenic tumor (APOT)

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14
Q

what is the most common odontogenic tumor in dogs?

A

caa

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15
Q

what breeds may be overrepresented when it comes to CAA?

A

golden retrievers
akitas
cocker spaniels
shetland sheepdogs

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16
Q

what tissues does the CAA originate from?

A

rest of serres

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17
Q

what are the unique features of CAA on histo?

A
  • does not demontrate stellate reticulum-like features.
  • has an internal sheet of interlocking polygonal epithelial cells reminiscent of the epithelial cells of the stratum spinosum of the skin or oral mucosa ( This is what the term ‘‘acanthomatous’’ refers to)
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18
Q

what type of ameloblastoma commonly features cystic degeneration?

A

conventional ameloblastoma

19
Q

what differentiates CAA from conventional ameloblastoma

A

CAA does NOT present with the stellate-reticulum-like cells

other cardinal signs of odontogenic epithelium are present in both

20
Q

what tumor presents in the cat associated with an unerupted maxillary canine?

A

feline inductive odontogenic tumor

21
Q

what odontogenic tumor appears in young (8-18 months old) cats?

A

feline inductive odontogenic tumor

22
Q

what odontogenic tumor looks like a honeycomb on x-ray?

A

odontogenic myxoma

23
Q

what is the only tumor derived form the ectomesenchyme of the dental papilla?

A

myxomatous tumor of the jaw

odontogenic myxoma

24
Q

what are the 3 mixed odontogenic tumors?

A

odontoameloblastoma
ameloblastic fibro-odontoma
odontoma

25
Q

what would be the difference between odontomas and odontogenic dysplasia?

A

odontoma: neoplastic or hamartomatous lesion

Odontogenic dysplasia: (elodontoma) caused by inflammation

26
Q

what odontogenic tumors arise in young animals?

A

odontomas

feline inductive odontogenic tumor

27
Q

what odontogenic tumors is often associated with a deviation from the normal quantity of teeth?

A

odontoma

28
Q

what are the 2 types of odontomas and what is the difference?

A

compound: rudimentary tooth-like structures, advanced differentiation
complex: disorderly comglomerate of odontogenic germinal tissues

29
Q

what is apthognomonic for compound odontoma?

A

denticles

30
Q

what type of dontongenic tumor is often compared to a harmatoma?

A

compound odontoma

31
Q

what does FEPLO stand for?

A

fibromatous epulis of periodontal ligament origin

same lesion as POF

32
Q

what is the second most common odontogenic tumor?

A

POF

33
Q

where does FEPOL/POF arise from according to bell?

A

PDL or gingival ligament at the site of gingival attachement on the tooth

34
Q

what is the anatomic predispostion for POFs?

A

rostral maxilla

caudal mandible

35
Q

what are the histologic characteristics of POF?

A
  • variably dense and proliferative mesenchymal cells embedded in a collagenous stroma reminiscent of PDL/gingival ligament
  • variable amounts of odontogenic epithelium
  • trabeculae of variably mineralized cemento-osseous matrix.
  • is foremost a lesion of proliferative mesenchymal cells with features of PDL‐ derived fibroblasts. The bulk of the lesion is fibrous mesenchyme.
36
Q

what odontogenic tumors are benign but locally agressive?

A

conventional ameloblastoma
CAA
amyloid-producing odontogenic tumor
feline inductive odontogenic tumor

37
Q

what is the enamel organ?

A

structure that produces enamel

includes the outer enamel epithelium, the stellate reticulum and the inner enamel epithelium.

38
Q

what is the stellate reticulum?

A

central region of the enamel organ

39
Q

what is the dental lamina?

A

specialized invagination of the embryologic gingival epithelium that gives rise to the enamel organ

40
Q

what is the dental follicle?

A

ectomensenchymal tissue that envelops the enamel organ and dental papilla

41
Q

what is the dental papilla?

A

ectomesenchyme that gets induced by odontogenic epithelium, gives the pulp

42
Q

what ‘‘structure’’ gives rise to the enamel organ?

A

dental lamina

43
Q

what ‘‘structure’’ gives rise to the pulp and odontoblasts?

A

dental papilla

Oral medicine (8 decks)

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