Ocular Pharmacology Flashcards

1
Q

T/F: The eye is small and simple

A

F: the eye is very complex

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2
Q

T/F: The eye has no built-in defense mechanisms

A

F: ocular defense mechanisms include eyelids, eyelashes, tears and tear components, and the bony orbit

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3
Q

T/F: The cornea has many nerve fibers

A

T: this is an advantage with the administration of eye medication
can be a disadvantage in terms of discomfort

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4
Q

What part of the eye do cataracts develop?

A

Cataracts are a result of clouding IN the lens of the eye-internal, suspended behind the iris and the pupil

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5
Q

What is the best type of ocular product?:

Solution
Suspension
Ointment
All are Equal

A

Solution- there is more surface area because the drug particles are suspended in there

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6
Q

Eye drop administration hints:

A

squeezing the bottle:
done between the middle finger and thumb

refrigeration:
provides the sensation that the drop went into the eye

punctual occlusion:
putting pressure on the corner of the eye with the index finger, ensures drug product is absorbed into the eye

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7
Q

Sharp/Stabbing Pain:

A

sign of: intraocular inflammation, something in the eye

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8
Q

Scratchy, gritty feeling

A

sing of: conjunctivitis and less complicated disorders

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9
Q

Vision reduction

A

reduction in vision is a result of various conditions:

changes in the cornea, cataracts, and intraocular inflammation

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10
Q

Length of Symptoms

A

length of time symptoms have existed reflects whether a situation is acute or chronic

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11
Q

Ophthalmologist

A

surgical interventions

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12
Q

Optometrist

A

manage chronic diseases, inflammatory diseases, and regular vision issues

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13
Q

Conjunctivitis

A

redness associated with conjunctivitis is diffuse and non patterned

can be: bacterial, viral, or allergic

treatment:
topical decongestant, no longer than 72hrs due to rebound congestion

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14
Q

Bumps/Water Blisters

in conjunctiva lining

A

irritating but not painful
allergies are the likely cause: face wash, cream, make up, etc.

treatment:
Ketofilen

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15
Q

Bacterial Conjunctivitus:

A

yellow discharge-associated with bacterial presence
complaints of eye being stuck shut in the morning
staph/strep: most common cause of bacterial infection

treatment:
OTC ointment rubbed in junction of eyelids when eye is closed (QID dosing at first)

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16
Q

11% of the population is allergic to what antibiotic?

A

neomycin

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17
Q

Patterened Redness:

A

begins at the adge of the iris and raidates outward
discomfort: iritis, caused by infalmmation of muscle interal to the eye

treatment:
referral-which will lead to topical corticosterioid & myadriatic/cyclopolegic

18
Q

Topical Corticosteroid:

predinsolone acetate 1%

A

admin: QID is most cases
cheap and effective
#1 choice
acetate is most potent

19
Q

Topical Corticosteroid:

Fluorometholone acetate or alcohol (use acetate)

A

increases IOP less than prednisolone

75% of patients will not have significant IOP response, 20% minimal response, and 5% signigicant response

20
Q

Normal IOP

A

10-20mmHg

steroids increase IOP so long-term use requires monitoring

21
Q

Angle Closure Glaucoma

A

pupil-mid dialated, redness radiates away from the edge of the iris, intense pain
-aqueous build up leads to pressure on the optic nerve, as result there is too much aqueous humor

IMMEDIATE REFERRAL: occular emergecy: opthamologist or emergency room

treatment:
pilocarpine or hyperosmotic agent

22
Q

Stye

A

warm compresses may be useful
stye ointment provides no therapeutic value
topical antimicrobial therapy may be useful

OTC stye products are useless
patient may need to optometrist or ophthalmologist

23
Q

Pseudomonas

A

the cornea is the best-known growth media for Pseudomonas aeruginosa

  • 11% of the population pseudomonas in their saliva
  • do not wet contact with saliva
24
Q

Eye Spalshes

A

base-penetrates better into the cornea would rather have acid splashed into the eye

25
Acid Burns
acid burns are less damaging than base burns
26
Base burns
bases cause greater protein denaturation
27
Eye Splashes
- irrigation of the eye -tap water is fine, you don't need eye wash - don't allow patients to use contact solution or saline in the body - patient should be referred for emergency care immediately - be careful not to rinse the eye with a strong stream of fluid that directly hits the cornea
28
Open Angle Glaucoma
goal of treatment is to prevent blindness: treating their IOP in order to treat their eyesight
29
Glaucoma
open-angle angle-closure ocular hypertension IOP is a surrogate for effectiveness of therapy
30
Ocular HTN and Glaucoma
monitoring parameters- drug, dose, frequency: 1st line of treatment for ocular HTN and glaucoma ``` beta blockers prostaglandin analogues CA-I Rho Kinase inhibitors Cholinergic Sympathomimetics ```
31
Beta Blockers
``` block beta 1 and beta 2 receptors Timolol (gold standard) Levobunolol Metripranolol Cartecol ``` beta 1 specific: Betaxolol given 2x a day primary side effects: stinging, punctuate keratitis, corneal anesthesia
32
Prostaglandin Analouges
no difference in therapy-just pick any one administered daily (at bedtime) -- increases their efficacy bimatoprost latanoprost latanoprostene travoprost tafluprost primary side effects: headache, iris pigmentation, superficial punctuate keratitis, latisse, mild-moderate ocular irritation, foreign-body sensation, conjunctival hyperemia
33
Carbonic Anhydrase Inhibitors
basically the same--> dorzolaide 2% brinzolamide 1% oral products acetazolamide-also injectable methazolamide given 3x a day primary side effects: metallic taste, drowsiness, malaise (flu-like symptoms), paresthesias (in fingers) capping the bottle minimizes the risk of administration
34
Rho Kinase Inhibitors
``` Netarsudil (Rhopressa) reduce intraocular pressure -increase trabecular outflow -decreases episcleral pressure -reduces the production of aqueous humor ``` primary side effects: hyperemia, corneal changes, and pain on instillation dosed once daily in the evening
35
Cholinergics
constrict the pupil and removes the anatomical barrier immediately pilocarpine 0.25%-10% carbachol 0.75%-3% echothiophate iodide 0.03%-0.25%
36
Hyperosmotic Agents
giving someone a hyperosmotic pulls fluid out and into the vasculature -a symptom is being thirsty defeating the purpose-so patients will have to hold off on water Mannitol: IV Glycerin/Isosorbide: PO (glycerine makes it palatable, isosorbide given to diabetics)
37
Sympathomimetic Agent
administered 2x daily not used frequently due to adverse effects associated with them dipivefrin: prodrug reducing toxicity replaced epinephrine apraclonidine: administered short term prior to surgery due to tachyphylaxis
38
Oral Corticosteroids
low potency, intermediate potency, high potency | salts forms & acetate forms: acetate form is the most potent
39
Prednisolone Acetate 1%
also known as Pred Forte the best product to use in terms of efficacy -treatment is for 4-6 weeks -if the patient is on it for at least 4 weeks-follow up appt is needed to check IOP 5% population IOP inc. greater than 6-15mmHg 30% population IOP inc. of 6-15mmHg
40
Mydriatic Cycloplegics
patient should know it takes a while for these drugs to wear off -need to continue to wear sunglasses