Ocular Immunology Flashcards
What are innate defences of the eye
physical barrier - eyelids and lashes
Tears to wash away microbes
Tear fluid contains mucins which bind antigens
What are adaptive defences in the eye
IgA in tear fluids
Conjunctival epithelial cells
Gamma/delta T cells
Langerhans cells
What are characteristics of immune privilege?
Low level of leucocyte recruitment and traffic
No professional APCs
An environment that is immunologically downregulatory
No conventional lymphatics
How does aquoeus fluid downregulate T cell response
TGF beta - suppresses T cell proliferation
Vasointestical protein
Calcitonin gene related proteins
aMSH
Somatostatin
Macrophage migration inhibitory factor
Soluble FasL - binds to Fas on activated immune cells to induce apoptosis
What are mucosa associated lymphoid tissues?
GI
REsp
Urethrogenital
Conj
Galnds of ocular adenexa
