Cytokines

Question 1

IL1 a/b

Answer 1

Macrophage

Actions:
Fever
T cell activation
Macrophage activation

Question 2

IL2

Answer 2

T Helper 1 cells

Actions
Growth of T cells, B cells, NK cells

Question 3

IL4

Answer 3

T helper 2 cells

Actions: activation of B cells, induces differentiation of CD4 T cells into T helper 2 cells

Question 4

IL6

Answer 4

Macrophage

Actions: acute phase proteins, lymphocyte activation, stimulates antibody production

Question 5

IL8

Answer 5

Macrophage

Actions: chemotaxis and activation of neutrophils

Question 6

IL10

Answer 6

T Helper 2 cells

Actions: inhibit immune function

Question 7

IL12

Answer 7

Macrophage

Actions: activation of NK cells, induces differentiation of CD4 T cells into T helper 1 cells

Question 8

IL 17

Answer 8

T Helper 17 cell

Actions: induces inflammatory response, recruitment of neutrophils

Question 9

Interferon a and b

Answer 9

Primarly from T cells, B cells, Monocyte/ Macrophage

Actions: inhibit viral replication

Question 10

Interferon γ ( gamma)

Answer 10

T helper 1 cells, NK cells

Actions: activation of macrophage, NK cells inhibit viral replication, increase expression of MHC I and II, inhibit T helper 2 cells

Question 11

TNF α/β

Answer 11

Primarily from T helper cells, macrophage

Action: activation of macrophage, nitric oxide production, induces inflammatory response including fever

Question 12

What cytokine is implicated in GCA path

Answer 12

IL6