Obstructive Lung Disease Flashcards
1
Q
Omalizumab
A
Shown to decrease exacerbation and need for steroids
IgE levels 30-700
Binds to IgE preventing binding to mast cells
2
Q
Reactive Airway Dysfunction Syndrome
A
Form of irritant induced asthma
Triggered by high level exposure to non immunological stimulus
Symptoms within minutes
Followed by reactive airways that can last longer
3
Q
Occupational Eosinophilic Bronchitis
A
Presents with persistent cough
No variable airflow obstruction
No hyper responsiveness
4
Q
Mepolizumab
A
- For eosinophilic asthma
- steroid responsiveness
- thickening of basement membrane
- more common in late onset
- less associated with atopy
- antibody against IL-5
- stimulated eo proliferation and activation
- reduces exacerbations and oral steroids
- for eo count >150
5
Q
Oxygen Use in COPD
A
Resting PaO2 <= 55
PaO2 56 to 59 with evidence of cor pulmonale or polycythemia
6
Q
COPD Assessment Test
A
- 8 item questionnaire
- range from 0 to 40
- can discriminate between sexes
- score > 10 - consider maintenance therapies
7
Q
Nonasthmatic eosinophilic bronchitis
A
- one of major causes of chronic cough
- normal imaging and normal PFTs
- diagnosed bu eosinophils on induced sputum
- commonly resolves with inhaled steroids
8
Q
Exercise Induced Bronchoconstriction
A
- first do methacholine challenge
- if negative do other test
- most specific test in eucapnic voluntary hyperpnea test
- 10-15% drop in FEV1
- can also do exercise challenge test
- hyperosmolar aerosol challenges
- dry powder mannitol inhalation test
9
Q
Pulmonary Rehab
A
- start immediately after hospitalization
- decrease in exacerbations, hospitalization and death
10
Q
Sputum Eosinophils
A
- monitoring and adjusting inhaled ICS can reduce risk of exacerbations by 1/2 - 2/3
- in moderate to severe asthma
- due to reduction in eosinophilic exacerbations
- most beneficial in patients on LABA
11
Q
BODE
A
- BMI, Obstruction, Dyspnea, Exercise
- post bronchodilator FEV1
- used for prognosis in COPD
