Obstetrics: Antenatal Care- Placenta Complications Flashcards

1
Q

Define antepartum haemorrhage

State some possible causes of PV bleeding in 1st, 2nd and 3rd trimester

A

Bleeding after 24 weeks gestation

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2
Q

State some causes of antepartum haemorrhage

A
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3
Q

Should vaginal examination be performed in antepartum haemorrhage?

A

*vaginal examination should not be performed in primary care for suspected antepartum haemorrhage - women with placenta praevia may haemorrhage

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4
Q

How does RCOG define severity of antepartum haemorrhage?

*HINT: there are 4 categories

A
  • Spotting: spots of blood noticed on underwear
  • Minor haemorrhage: less than 50ml blood loss
  • Major haemorrhage: 50 – 1000ml blood loss
  • Massive haemorrhage: more than 1000 ml blood loss, or signs of shock
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5
Q

What is placenta praevia?

How common in placenta praevia?

A
  • Placenta praevia is where the placenta is fully or partially attached to the lower uterine segment
  • 1% pregnancies
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6
Q

RCOG recommend using the descriptions ‘low-lying placenta’ and ‘placenta praevia’; however, traditionally there are 4 grades of placenta praevia- describe these

A
  • Minor praevia/grade I = the placenta is in the lower uterus but not reaching the internal cervical os
  • Marginal praevia/grade II = the placenta is reaching, but not covering, the internal cervical os
  • Partial praevia/grade III = the placenta is partially covering the internal cervical os
  • Complete praevia/grade IV = the placenta is completely covering the internal cervical os

****The RCOG guidelines (2018) recommend against using this grading system, as it is considered outdated. The two descriptions used are low-lying placenta and placenta praevia

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7
Q

What is a low-lying placenta?

A

Placenta is within 20mm of internal cervical os

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8
Q

State some risk factors for placenta praevia

A
  • Previous caesarean sections (embryo more likely to implant in scar)
  • Previous placenta praevia
  • Multiparity
  • Multiple pregnancy
  • Older maternal age (>35/40yrs)
  • Maternal smoking
  • Structural uterine abnormalities (e.g. fibroids)
  • Assisted reproduction (e.g. IVF)
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9
Q

Describe how placenta praevia may present

A
  • Many are asymptomatic and it is detected on 20-week anomaly scan
  • May present with painless vaginal bleeding in pregnancy (antepartum haemorrhage)- usually occurs later in pregnancy ~36 weeks or after
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10
Q

Discuss the management of placenta praevia and low-lying placenta

A

If have low-lying placenta or placenta praevia diagnosed in early pregnancy (e.g. 20 week anomaly scan):

  • Repeat transvaginal ultrasound at 32 weeks gestation and again at 36 weeks gestation if still present on 32 week scan

If still have low-lying placenta or placenta praevia later in pregnancy:

  • Corticosteroids between 34 and 35+6 weeks to mature fetal lungs given the risk of preterm delivery
  • Planned caesarean section between 36 and 37 weeks gestation
  • Ultrasound performed at time of delivery to check position of placenta and fetus as different incisions may have to be made
  • If woman has premature labour or antenatal bleeding then may have to do emergency caesarean section (PassMed says if goes into premature labour must do C-section to prevent post-partum haemorrhage)
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11
Q

Why is delivery planned early (between 36 and 37 weeks) in placenta praevia?

A

To reduce risk of spontaneous delivery & bleeding

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12
Q

State some potential complications of placenta praevia

A
  • Haemorrhage (before, during and after delivery)
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13
Q

Main complication of placenta praevia is haemorrhage. Discuss potential management options of haemorrhage

A

A-E assessment and:

  • Emergency caesarean section
  • Blood transfusions
  • Intrauterine balloon tamponade
  • Uterine artery occlusion
  • Emergency hysterectomy
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14
Q

Notes from Teachmeobygyn about antepartum haemorrhage questions

A

The following questions are useful to ask in the assessment of antepartum haemorrhage:

  • How much bleeding was there and when did is start?
  • Was it fresh red or old brown blood, or was it mixed with mucus?
  • Could the waters have broken (membranes ruptured?)
  • Was it provoked (post-coital) or not?
  • Is there any abdominal pain?
  • Are the fetal movements normal?
  • Are there any risk factors for abruption? e.g. smoking/drug use/trauma – domestic violence is an important cause.

If the bleed is ongoing, or if there has been a significant vaginal bleed, ABC assessment and resuscitation is vital. If the woman is clinically stable, proceed to examination.

General Examination

On general examination, the following should be assessed:

  • Pallor, distress, check capillary refill, are peripheries cool?
  • Is the abdomen tender?
  • Does the uterus feel ‘woody’ or ‘tense’ (which may indicate placental abruption)?
  • Are there palpable contractions?
  • Check the lie and presentation of the fetus/fetuses. Ultrasound can be used to help.
  • Check fetal wellbeing with a cardiotocograph (CTG) at 26 weeks gestation or above: (otherwise auscultate the fetal heart only).
  • Read the hand-held pregnancy notes: are there scan reports? This will be helpful in establishing whether there could be placenta praevia

Assessment of Bleeding

Lastly, the bleeding itself should be assessed:

  • Externally e.g. by looking at pads.
  • Cusco speculum examination: avoid this until placenta praevia has been excluded by USS.
    • Look for whether blood is fresh red or dark. How much blood is there? Are there clots? Are there any cervical lesions? Is there any cervical dilatation, or any chance that the membranes have ruptured?
  • Take triple genital swabs to exclude infection if the bleeding is minimal
  • Digital vaginal examination: A digital vaginal examination with known placenta praevia should NOT be performed as it could cause massive bleeding.
    • In minor bleed, when placenta praevia is excluded, it can help to establish whether the cervix is beginning to dilate.
    • Avoid digital VE if the membranes have ruptured.
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15
Q

What is vasa praevia?

A

Condition in which fetal vessels (umbilical arteries & vein) are within the fetal membranes (chorioamniotic membranes)- hence are unprotected- and travel across internal cervical os

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16
Q

Discuss the pathophysiology of vasa praevia- include the two types

A
  • Normally, umbilical cord inserts directly into placenta and hence fetal vessels are always protected by either umbilical cord or the placenta
  • There are two types of vasa praevia:
    • Type I: fetal vessels are exposed as a velamentous umbilical cord (umbilical cord inserts into chorioamniotic membrane and then fetal vessels travel unprotected through membranes before joining the placenta)
    • Type II: fetal vessels are exposed as they travel to an accessory placental lobe (accessory lobe is connected to placental lobes by fetal vessels which travel through chorioamniotic membrane)
17
Q

What usually protects fetal vessels when in the umbilical cord?

A

Wharton’s jelly (a layer of soft connective tissue that surrounds the blood vessels in the umbilical cord)

18
Q

State some risk factors for vasa praevia

A
  • Low lying placenta
  • IVF pregnancy
  • Multiple pregnancy
19
Q

Discuss how vasa praevia may present/be diagnosed

A
  • IDEALLY, diagnosed by ultrasound antenatally as this allows planned caesarean section to reduce risk of haemorrhage; however, not always possible to diagnose antenatally as ultrasound unreliable
  • May present with antepartum haemorrhage during 2nd or 3rd trimester
  • May be detected during vaginal examination during labour when pulsating fetal vessels seen through dilated cervix
  • May be detected during labour when there is fetal distress and dark-red bleeding following rupture of membranes

***Last situation has very high fetal mortality even with emergency caesarean section

20
Q

Discuss the management of vasa praevia; consider management in:

  • Asymptomatic women
  • If antepartum haemorrhage occurs
A

Asymptomatic women:

  • Corticosteroids from 32 weeks gestation to mature fetal lungs
  • Elective caesarean section planned for 34-36 weeks gestation

If antepartum haemorrhage occurs:

  • Emergency caesarean section
  • ***After stillbirth or unexplained fetal compromise during delivery placenta is examined for evidence of vasa praevia as possible cause*
21
Q

Remind yourself of the 3 layers of the uterine wall

A
  • Endometrium: inner layer that contains connective tissue (stroma), epithelial cells and blood vessels
  • Myometrium: middle layer that contains smooth muscle
  • Perimetrium: outer layer, which is a serous membrane similar to the peritoneum (also known as serosa)
22
Q

What is placenta accreta?

A

Placenta accreta refers to when the placenta implants deeper, through and past the endometrium, making it difficult to separate the placenta after delivery of the baby. It is referred to as placenta accreta spectrum, as there is a spectrum of severity in how deep and broad the abnormal implantation extends

23
Q

When talking about placenta accreta we use different definitions to describe the depth of invasion; define the following:

  • Superficial placenta accreta
  • Placenta increta
  • Placenta percreta
A
  • Superficial placenta accreta: the placenta implants in the surface of the myometrium, but not beyond
  • Placenta increta: the placenta attaches deeply into the myometrium
  • Placenta percreta: the placenta invades past the myometrium and perimetrium, potentially reaching other organs such as the bladder
24
Q

State some risk factors for placenta accreta

A
  • Previous placenta accreta
  • Low-lying placenta or placenta praevia
  • Previous endometrial curettage procedures (e.g. for miscarriage or abortion)
  • Previous caesarean section
  • Multigravida
  • Increased maternal age
25
Q

Describe presentation of placenta accreta/how diagnosed

A
  • Doesn’t usually cause symptoms but may cause antepartum haemorrhage in 3rd trimester
  • May be diagnosed on antenatal ultrasound scans
  • May be diagnosed at birth when it becomes difficult to deliver placenta
26
Q

Discuss the management of placenta accreta

A

Managed by specialist MDT:

  • MRI pelvis may be used to assess depth and width of invasion
  • Corticosteroids to mature fetal lungs
  • Planned caesarean section between 35 and 36+6 weeks (reduce risk of spontaneous labour & delivery)
  • Options during caesarean include:
    • Hysterectomy with placenta remaining in uterus (recommended)
    • Uterus preserving surgery in which part of myometrium is resected along with placenta
    • Expectant management (leaving placenta in place to be reabsorbed over time)
  • May require additional management at birth- this could include:
    • Blood transfusions
    • Intensive care for the mother
    • Neonatal intensive care

NOTE: The RCOG guideline (2018) suggests that if placenta accreta is seen when opening the abdomen for an elective caesarean section, the abdomen can be closed and delivery delayed whilst specialist services are put in place. If placenta accreta is discovered after delivery of the baby, a hysterectomy is recommended.

27
Q

Expectant management of placenta accreta comes with significant risks; true or false?

A

True; main risks are bleeding & infection

28
Q

State some potential complications of placenta accreta

A
  • Biggest complication/risk is post-partum haemorrhage
  • Premature birth
  • Usual risks of caesarean section
  • Risk of infection in expectant management
29
Q

What is placental abruption?

A

Part or all of placenta separates from wall of uterus during pregnancy; site of attachment can bleed extensively after placenta separates hence it is a cause of antepartum haemorrhage

30
Q

Discuss the pathophysiology of placental abruption

A
  • Thought to be due to rupture of maternal vessels within basal layer of endometrium
  • Blood accumulates and causes placenta to detach from basal layer
  • Detached portion of placenta unable to function hence causes rapid fetal compromise
31
Q

There are two types of placental abruption; state and describe each

A
  • Revealed – bleeding tracks down from the site of placental separation and drains through the cervix. This results in vaginal bleeding.
  • Concealed – the bleeding remains within the uterus, and typically forms a clot retroplacentally. This bleeding is not visible, but can be severe enough to cause systemic shock
32
Q

State some risk factors for placental abruption

A
  • Previous placental abruption (most predictive factor)
  • Pre-eclampsia
  • Bleeding early in pregnancy
  • Abdominal trauma (consider domestic violence)
  • Multiple pregnancy
  • Fetal growth restriction
  • Multigravida
  • Increased maternal age
  • Smoking
  • Cocaine or amphetamine use
33
Q

Describe typical presentation of placental abruption

A
  • Sudden onset, continuous abdominal pain
  • Antepartum haemorrhage/vaginal bleeding (BUT remember won’t be present in concealed placental abruption)
  • Shock (hypotension & bradycardia)
  • Fetal distress shown on CTG
  • Woody” abdomen on palpation (tense all time. Suggests large haemorrhage)
34
Q

Are there any reliable tests for diagnosing placental abruption?

A

No reliable tests it is a clinical diagnosis

*Ultrasound has a good positive predictive value but poor negative predictive value hence cannot be used to exclude placental abruption

35
Q

Placental abruption is an obstetric emergency; true or false?

A

True

36
Q

Discuss the management of placental abruption (not asking for management of major or massive haemorrhage)

A

First step is A-E assessment. If having major or massive haemorrhage manage accordingly (see separate FC). Ongoing management then depends on health of fetus:

Fetus alive and <36 weeks

  • Fetal distress → emergency caesarean section
  • No fetal distress →
    • Monitor closely
    • Antenatal steroids between 24 weeks and 34+6 weeks to mature fetal lungs
    • Anti-D prophylaxis in rhesus negative women within 72hrs. If >20 weeks do Kleihauer test to determine dose of anti-D

Fetus alive and >36 weeks

  • Feta distress → emergency caesarean section
  • No fetal distress → induction of labour & vaginal delivery

Fetus dead

  • Induce vaginal delivery
  • **Active management of 3rd stage is recommended as there is increased risk of post-partum haemorrhage after delivery in woman with placental abruption*
37
Q

Discuss the initial management of major or massive antenatal haemorrhage

A
  • Urgent escalation to seniors including obstetrician, midwife and anaesthetist
  • 2 x grey/wide bore cannulas
  • Bloods include FBC, U&Es, LFT, coagulation studies, G&S, crossmatch
  • Crossmatch 4 units of blood
  • Fluid and blood resuscitation as required
  • CTG monitoring of the fetus
  • Close monitoring of the mother
38
Q

State some potential maternal & fetal complications of placental abruption

A

Maternal

  • shock
  • DIC
  • renal failure
  • PPH

Fetal

  • IUGR
  • hypoxia
  • death

*placental abruption associated with high perinatal mortality rate