Obstetrics Flashcards
Which class of diabetes medication is contraindicated in pregnancy AND breastfeeding?
Sulphonylureas (Gibenclamide, Gliplizide
Tolbutamide, Gliclazide)
Glinides (Repaglinides, nateglinide.)
What effect does pregnancy have on the thyroid?
Increase in size
Increase TBG levels
IncreasesfT4, decreasesTSH
What effect does HCG have on thyoxine levels?
Increases it
What effect does pregnancy have on Grave’s Disease?
Grave’s disease is often SUPRESSED during pregnancy (as there is immunosuppression in this time.) BUT rebound postpartum
Thyroid receptor antibodies TRAB should be measured in 3rd trimester to predict thyrotoxicosis risk for baby.
May require small doses of Carbimazole.
Managing Grave’s in pregnancy?
‘Wait & See’
1st trimester - avoid carbimazole & use Propythyouracil
2nd trimester - give carbimazole
What effect does hypothyroidism have on pregnancy?
Cretinism - dwarfism plus limited mental functioning.
risks infertility, pre-eclampsia, post-partum haemorrhage & preterm labour.
How should levels of levothyroxine be altered for pregnant women with hypothyroidim?
Increased by 50%
What crisis can be precipitated by labour? (related to the thyroid)
Thyroid crisis & transient neonatal thyrotoxicosis
What are the complications of thyroid crisis in labour?
increases risk of miscarriage, stillbirth
Which hormones are secreted from the posterior pituitary?
Oxytocin & ADH
Where is prolactin released from?
Anterior pituitary
How does pregnancy affect the respiratory system?
Tidal volume increases
Minute ventilation increases (Tidal volume x RR)
What is dilutional anaemia?
This is when plasma volume rises in pregnancy & RBCs are diluted. Hb conc falls
What is first line contraception for women who are breastfeeding?
Progesterone only
Can be used first day postpartum
Implant is most effective
IUS & IUD SHOULD BE AVOIDED DUE TO RISK OF PERFORATION.
Which contraceptives are contraindicated postpartum & why?
COC due to increases risk of VTE
IUS & IUD SHOULD BE AVOIDED DUE TO RISK OF PERFORATION.
Ibuprofen & Paracetamol can safely be used for analgesia during breastfeeding T/F?
True
Is aspiring contraindicated in breastfeeding?
Yes. (can lead to liver failure & thrombocytopenia in infant)
Opiates are contraindicated in breastfeeding T/F?
F - use with caution & seek help signs of toxicity
In CTG what does prolonged decceleration indicate?
Prolonged deccelaration >3min
Foetal bradycardia
On CTG what is a normal baseline variability?
> 5bpm
What is normal pH levels on foetal blood sampling?
> 7.25
What is a normal foetal heart rate?
100-160bpm
adult 60-100
What is Bishop’s score used for?
Check if its safe to induce labour
Induction of labour if bishop’s score is?
<5 labour unlikely to start without induction
>9 means its likely to occur spontaneously