Obstetrics Flashcards
Which hormone triggers a surge in LH?
Estrogen during the follicular phase
What does a surge in LH lead to
ovulation
Which medications have placental transmission?
- Acutane
- Antidepressant (sodium valproate)
- Anticonvulsants
- Anticoagulants
- Vitamins ADEC in excess
When would you refer for genetic counseling?
- advanced maternal age
- suspected carriers for gene
- family condition/trait
- recurrent SAB
- unexplained fetal death
- SIDS hx
Carrier tests are available for which conditions?
- Sickle Cell
- Tay Sachs
- Thalassemias
- Cystic Fibrosis
T/F: Tay sachs screening is offered if both parents are Jews
True
What percentage of pregnancies are unplanned?
50%
Define infertility
inability to conceive after 1yr of trying
When should you intervene with an eval and workup for infertility?
If <35yo, wait 1yr;
If >35yo, wait only 6mo
What are the 3 primary causes of infertility?
1- Pelvic factors (PID, adhesions, inflam)
2- Semen defect (amount, motility, morph)
3- Ovulatory defect (progesterone, cycle, luteal phase defect)
What is labs are performed on an infertility workup?
- Fertility awareness edu.
- TSH
- FSH
- Progesterone
- Prolactin
- Semen analysis
When would you perform a hysterosalpingogram w/ infertility?
Checking for potency of tubes or anatomical obstructions
When would you perform laparoscopy w/ infertility?
checking for adhesions and fibroids or cysts
Which are 3 requirements for successful conception?
Egg, sperm, good environment
Where does conception occur?
FIMBRIA OR AMPULLA
How long is the egg viable for, once released?
24hrs
When is hCG produced?
When egg burrows into endometrium
- hCG triggers corpus lute to secrete prog past its normal 14 days
Once implantation occurs, how long does the corpus lute secrete prog for?
12-16th week, until placenta takes over
Why might there be increased hCG on pregnancy test?
- Pregnancy (normal or complicated)
- Ovarian tumor
- Testicular cancer
What is the pattern of hCG increase with pregnancy?
- doubles every 48-72hrs
- peaks at 50-75 days
What timeframe is considered for spontaneous abortion?
loss of fetus before 20 weeks gestation
Describe threatened abortion
spotting/bleeding w/ NO significant cramps/clots
Describe inevitable abortion
- Heavy bleeding, cramps, cervix dilated, ROM, no FHTs
- decrease in hCG
- before wk 10 - natural course
- after wk 10 = D&C
Describe incomplete abortion
Part or all of POC (products of conception) remained in uterus
What are s/sx of incomplete abortion? Next steps?
- bleeding and pain
- monitor for infection/hemorrhage and refer for D&C
Describe complete abortion
all POC expelled
- 2-3wk follow up with provider
Describe missed abortion
Death of embryo or fetus with retained POC
- requires D&C
What is habitual abortion?
3 successive pregnancy losses
- requires referral
What is a septic abortion?
POC infected, may lead to systemic infection
What are s/sx of septic abortion?
- increased bleeding
- malodorous vaginal d/c
- pain
- fever/chills
- leukocytosis
What is a blighted ovum?
- Egg gets fertilized and implants- but does NOT develop
What is the usual cause for an anembryonic pregnancy/blighted ovum?
chromosomal abnormality
What is the presentation of ectopic pregnancy?
bleeding, pain, s/s of pregnancy
How do you dx ectopic pregnancy?
decreasing or low hCG levels and ultrasound
What are the risk of ectopic pregnancy?
- hemorrhage and death
- future infertility
- increased risk of future complications
what occurs when there is an overproduction of placental cells with an abnormally high hCG level?
hydatidiform mole
What is the typical presentation for a molar pregnancy?
- Large for gestational age
- bleeding and pain
- no fetal mvmt.
- more nausea than normal (hCG)
- no FHTs
Presence of a hydatidiform mole increases the risk for developing ________.
Choriocarcinoma
what are the common causes for first trimester SAB?
chromosomal abnorm, reproductive hazards and unknown
What are the common causes for second trimester SAB?
incompetent cervix, uterine septum, trauma
Which criteria help form a “Presumptive” pregnancy dx?
- Amennorhea
- N/V
- Mastodynia
- Quickening (baby moving)
- Urinary freq.
- Wt gain
- Fatigue
- Increase BBT
- Chloasma/linea nigra/darkened areola
Which criteria help form a “Probable” pregnancy dx?
- OTC pregnancy test (pos @ 12-14 days)
- Blood test (pos @ 9-11 days)
- Uterine changes (hegar’s & goodell’s)
- Ballotable mass
- Braxton-Hicks contractions
What is a ddx for probable pregnancy?
- choriocarcinoma, hydatidiform mole, ectopic pregnancy.
- obesity or neoplasm
- muscle spasm
Which findings suggest a definitive “POSITIVE” pregnancy?
FHTs, Ultrasound and X-Ray
What is the role of “relaxin”?
softens tissues and joints, secreted through breastfeeding
What is role of prostaglandins in pregnancy?
Present in amniotic fluid, menstrual blood and semen; ripens cervix and induces contractions
What is the role of progesterone in pregnancy?
- Secreted by CL then placenta
- promotes breast gland growth
- maintains pregnancy
Which form of estrogen is dominant through pregnancy?
E3 - Estriol, 1000x higher while prego
What is the role of prolactin in pregnancy?
Develops alveolar and glandular cells to help promote lactation and produces lactose and lipids
What is the role of oxytocin in pregnancy?
“Contractor hormone”
- secreted from post. pit. to express milk and stimulate the uterus
- induces labor and controls PP hemmorhage
What is piskacek’s sign?
asymmetric enlargement of the body of the pregnant uterus, an indication of pregnancy
What is goodell’s sign?
cervical softening, an indication of pregnancy
What is hegar’s sign?
Uterine isthmus softens. indication of pregnancy
What is chadwick’s sign?
bluish discoloration- increased vascularization of vaginal walls, indicating prengnancy
Which hormone inhibits egg maturation?
Progestin
Which hormone preserves corpus lute?
hCG
How does estrogen influence chloasma + similar conditions?
Estrogen stimulates melanocytes
Why and how is GI tract affected during pregnancy?
Relaxin from placenta causes GI relaxation, slowing food and water digestion
What are montgomery’s tubercles?
small glands around the nipples that secrete oils which lubricate and protect against infection
At what times do breasts become more enlarged w/ modularity and when do they express colostrum?
- nodularity/enlargement by 8wks
- colostrum (rich in Ab/PRO, low in lipids) by 12wks
What are the normal cardiovascular changes with pregnancy?
- CO increases, peaks @ 20-24wks
- BP decreases in 2nd tri
- HR increases by 10-15bpm
- LE edema/neous congestion
Why will pregnant women appear anemic on lab tests?
- Plasma increases more than RBC mass increases;
- Will appear anemic on labwork as there is a RELATIVE decrease in hematocrit and hemoglobin. “Macrocytic anemia” d/t hemodilution
Which respiratory changes are important with pregnancy?
increase in tidal volume and O2 uptake
Which GI condition is common in pregnancy?
cholestasis
Which skin conditions are very common w/ pregnancy?
- spider angiomas and varicosities
- hyperpigmentation
What is the difference between gravid and gravida?
one has an “a”;
- gravid = currently pregnant
- gravida = has been pregnant
Define nulligravida
never been pregnant
Define primigravida
pregnant for the first time
Define para
carried fetus to viability
Define primipara and multipara
carried one fetus and multiple fetuses to viability