Obstetrics Flashcards

1
Q

What is pre-eclampsia?

A

Hypertensive disorder.

Placental disease which can result in catastrophic maternal/foetal compromise.

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2
Q

What is the pathophysiology of pre-eclampsia?

A

Poor placental perfusion secondary to abnormal placentation.

In normal placentation the trophoblast invades the myometrium and spiral arteries of the uterus destroying the tunica muscularis media.

This renders the spiral arteries dilated and unable to constrict providing pregnancy with high flow, low resistance circulation.

In pre-eclampsia the remodelling of the spinal arteries is incomplete. A high resistance, low flow uteroplacental circulation develops as the constrictive muscular walls of the spiral arterioles are maintained.

This resultant increase in BP combined with hypoxia and oxidative stress from inadequate uteroplacental perfusion leads to a systemic inflammatory response and endothelial cell dysfunction (leading to leaky vessels)

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3
Q

What are the risk factors for pre-eclampsia?

A

Moderate
- Nuliparity
- Maternal age >40
- Maternal BMI>35
- FHx
- Pregnancy interval >10 yrs
- Mutiple pregnancy

High
- Chronic HTN, HTN, pre-eclampsia, eclampsia in previous pregnancy
- Pre-existing chronic kidney disease
- DM
- Autoimmune diseases (SLE, antiphospholipid syndrome)

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4
Q

Who is offered prophylaxis fro pre-eclampsia?

A

Women with 1 high RF or >/=2 moderate RFs.

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5
Q

What prophylaxis if offered for pre-eclampsia?

A

Aspirin 75mg a day.

Continued from 12 weeks gestation until birth.

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6
Q

What 3 criteria must be met for a woman to be diagnosed with pre-eclampsia?

A
  1. Hypertension on 2 occasions at least 4 hours apart (Systolic>140, Diastolic>90)
  2. Significant proteinuria (>300mg in 24 hours urine sample OR >30mg/mmol urinary protein:creatinine
  3. In a woman >20 weeks gestation
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7
Q

What are the clinical features of pre-eclampsia?

A

Asymptomatic (therefore BP and urine dipstick should be formed at each antenatal clinic)

  • Headaches (frontal)
  • Visual disturbances (blurred/double vision, halos, flashing lights)
  • Epigastric pain (hepatic capsule distension/infarction)
  • Sudden onset non-dependent oedema
  • Hyper-reflexia
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8
Q

What are the classifications for pre-eclampsia?

A

Mild
- BP 140/90-149/99 mmHg

Moderate
- BP 150/100- 159/109 mmHg

Severe
- BP >160/110 + proteinuria >0.5g/day
OR
- BP >140/90 + proteinuria + symptoms

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9
Q

What are some complications of pre-eclampsia?

A

Onset of pre-eclampsia before 34 weeks is associated with poorer diagnosis.

Maternal complications
- HELLP syndrome (haemolysis, elevated liver enzymes, low platelets)
- Eclampsia (seizures)
- AKI
- DIC
- ARDS
- HTN
- Cerebrovascular haemorrhage
- Death

Foetal complications
- Prematurity
- IUGR
- Placental abruption
- Intrauterine foetal death

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10
Q

What are the differential diagnoses for pre-eclampsia?

A

Essential HTN (HTN prior to 20 weeks gestation)

Pregnancy induced HTN (New onset HTN presenting after 20 weeks gestation without significant proteinuria)

Eclampsia (Pre-eclampsia & seizures): obstetric emergency

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11
Q

What investigations do you do for someone with suspected pre-eclampsia?

A

BP
Urine dipstick
24 hour urinary collection

Monitor signs of organ dysfunction (DIC/HELLP)
- FBC (low Hb, low platelets)
- U&Es (high urea, high creatinine, high urate, decreased urine output)
- LFTS (high ALT/AST)

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12
Q

How do you manage pre-eclampsia?

A
  1. Prevent development of eclampsia
  2. Minimise risk of complications for mother and foetus

Monitoring maternal and foetal wellbeing
- BP
- Urinalysis
- Blood tests
- Foetal growth scans
- Cardiotocography

VTE prevention (fluid management & low molecular weight heparin)

Antihypertensives (reduced risk of maternal haemorrhagic stroke, do not alter disease course)

Delivery (the only definitive cure) (prolonging the pregnancy is for the benefit of the foetus alone)
- if <35 weeks and delivery is considered, IM steroids administered to aid development of foetal lungs

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13
Q

What antihypertensives are used in pregnancy?

A

Severity of HTN correlates to the risk of stroke so it is important to maintain a BP at a level that minimises risk.

1st line: Labetalol (beta-blocker)
- SE= postural hypotension, fatigue, headache, N&V, epigastric pain
- Avoid if woman had asthma/DM

2nd line: Nifedipine (CCB)
- SE= peripheral oedema, dizziness, flushing, headache, constipation

3rd line: Methyldopa (alpha-agonist)
- SE= drowsiness, headache, oedema, GI disturbance, dry mouth, postural hypotension, bradycardia, hepatotoxicity

ACEi are CI in pregnancy due to association with congenital abnormalities.

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14
Q

How does pre-eclampsia resolve?

A

Following delivery of the placenta.

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15
Q

What post-natal care should the mother receive after suffering from pre-eclampsia?

A

Monitor mother for 24 hours (still at risk of having seizures, by day 5 they are safe)

BP monitored daily for 1st 2 days, and once 3-5 days post-partum. Need for antihypertensives should be reassessed.

Advise women of risk of developing pregnancy induced HTN and pre-eclampsia in subsequent pregnancies.

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16
Q

What is placenta praevia?

A

Where the placenta is fully/partially attached to the lower uterine segment.

Cause of antepartum haemorrhage (vaginal bleeding from week 24 of gestation until delivery)

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17
Q

What is the pathophysiology of placenta praaevia?

A

Minor: placenta is low but does no cover the internal cervical os

Major: placenta lies over the internal cervical os

Low lying placenta is more susceptible to haemorrhage due to a defective attachment to the uterine wall.

Bleeding can be spontaneous or provoked by mild trauma. Placenta may be damaged as the presenting part of the foetus moves into the lower uterine segment in preparation for labour.

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18
Q

What are the risk factors for placenta praevia?

A

Main RF: previous C section

  • High parity
  • Maternal age >40
  • Multiple pregnancy
  • Previous placenta praevia
  • Hx of uterine infection (endometritis)
  • Curettage to endometrium after miscarriage/termination
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19
Q

What are the clinical features of placenta praevia?

A

Antepartum haemorrhage (painless vaginal bleeding: spotting/massive haemorrhage)

Pain if woman is in labour

Examination may reveal risk factors.

Uterus not tender on palpation.

20
Q

How do you assess someone with an antepartum haemorrhage?

A

Hx
- How much bleeding and when did it start?
- Fresh red/old brown blood/mixed with mucus?
- Could the waters have broken?
- Was it provoked (post-coital)?
- Any abdominal pain?
- Are the foetal movements normal?
- Any risk factors for abruption (smoking/drugs/trauma)?

ABC assessment and resuscitation if significant bleed.

Examination
- Pallor/distress/check cap refill/ cool peripheries
- Abdomen tender?
- Does the uterus feel ‘woody’ or ‘tense’ which may indicate placental abruption?
- Are there palpable contractions?
- Check lie and presentation of foetus
- CTG (>26 weeks) otherwise auscultate heart
- Read pregnancy notes. Scan reports.

Assess bleeding
- Externally
- Speculum exam (avoid until placenta praevia has been excluded by USS)= fresh red/dark, how much, any clots, cervical lesions, cervical dilatation, ruptured membranes
- Triple genital swabs if minimal bleeding
- Digital vaginal examination (do not do this if placenta praevia as can cause massive bleeding, or if membranes have ruptured) to establish whether cervix is beginning to dilate

21
Q

What are the differential diagnosis for placenta praevia?

A

Placental praevia is not common.

  • Placental abruption (where all/part of the placenta separates from the wall of the uterus prematurely)
  • Vasa praevia (fetal blood vessels run near internal cervical os)
  • Uterine rupture (full thickness disruption of uterine muscle and overlying serosa, usually occurs in labour with history of previous C section/myomectomy)
  • Benign/malignant lesions (polyps/carcinoma/cervical ectropion)
  • Infections (BV, chlamydia, candida)
22
Q

What is the classic triad of Vasa praevia?

A
  1. Vaginal bleeding
  2. Rupture of membranes
  3. Fetal compromise

Bleeding occurs following membrane rupture when there is rupture of the umbilical cord vessels leading to loss of foetal blood and rapid deterioration in foetal condition.

23
Q

What investigations would you do if you you suspect major haemorrhage (placenta praevia)?

A

If major bleeding is suspected, resuscitate and perform investigations simultaneously.

Haematology
- FBC (anaemia)
- Clotting profile
- Kleihauer test (if woman is Rhesus -ve, to determine the amount of feto-maternal haemorrhage and therefore the dose of Anti-D required)
- G&S (if blood group unknown)
- Cross-match (if presentation is likely to warrant an infusion)

Biochemistry (rule out HELLP, pre-eclampsia, organ dysfunction)
- U&Es
- LFTs

CTG (if >26 weeks) to assess foetal wellbeing

Definitive diagnosis: USS (short distance between the lower edge of placenta and internal os)

24
Q

How do you manage placenta praevia?

A

Resuscitation A-E approach
Do not delay maternal resuscitation to determine foetal viability.

Can be identified at 20 week USS
- Minor (repeat scan at 36 weeks recommended and placenta likely to moved superiorly)
- Major (repeat scan at 32 weeks and plan for delivery made at this time: elective at 38 weeks)

C section is safest mode of delivery

In all cases of antepartum haemorrhage give anti-D within 72 hours of onset of bleeding if rhesus D -ve

25
What is placental abruption?
Where part/all of your placenta separates from the wall of the uterus prematurely. Antepartum haemorrhage: vaginal bleeding from week 24 of gestation until delivery
26
What is the pathophysiology of placental abruption?
Following a rupture of maternal vessels within the basal layer of the endometrium. Blood accumulates and split the placental attachment from the basal layer. The detached portion of the placenta is unable to function leading to rapid foetal compromise.
27
What are the types of placental abruption?
Revealed - bleeding tracks down from site and drains through cervix resulting in vaginal bleeding Concealed - bleeding remains in uterus forming a clot retroplacentally - bleeding not visible but can cause systemic shock
28
What are the risk factors for placental abruption?
- Placental abruption in previous pregnancy - Pre-eclampsia/HTN disorder - Abnormal lie of foetus (transverse) - Polyhydraminos - Abdominal trauma - Smoking/drug use - Bleeding in 1st trimester - Thrombophilia - Multiple pregnancy
29
What are the clinical features of placental abruption?
Antepartum haemorrhage. Painful vaginal bleeding. (If in labour, enquire about pain between contractions) Woody uterus (tense all the time) Uterus painful on palpation.
30
What are the differential diagnosis for placental abruption?
- Placenta praevia - Marginal placental bleed (small, partial abruption not large enough to cause maternal/foetal compromise) - Vasa praevia - Uterine rupture - Benign/malignant lesions (polyps/carcinoma/cervical ectropion) - Infections (candida/BV/chlamydia)
31
What investigations do you do if you suspect
32
What is IOL (Induction of Labour)?
Process of starting labour artificially. Most women will go into spontaneous labour by week 42 of gestation, 1 in 5 will require an induction. Performed when the baby will be safer delivered rather than remaining in utero, or for reasons concerning the mother's health.
33
When is IOL indicated?
Induction of labour should NOT be offered on maternal request alone. Prolonged gestation - Uncomplicated pregnancies offered IOL between 40+0 & 40+14 - Avoid foetal compromised and stillbirth associated with prolonged gestation - If IOL declined the frequency of monitoring from 42 weeks should be increased Premature rupture of the membranes - >37 weeks: offer IOL or offer expectant management for max 24 hours (any longer increases risk of chorioamnionitis) - <34 weeks: delay IOL unless obstetric factors indicate otherwise (foetal distress) - >34 weeks: timing of IOL depends on risks and benefits of delaying pregnancy further Maternal health problems - HTN - Pre-eclampsia - DM - Obstetric cholestasis Foetal growth restriction - 2nd most common indication for IOL - Deliver baby prior to foetal compromise IU foetal death - Labour offered if mother is well with intact membranes
34
What are the CI for IOL?
Absolute - Cephalopelvic disproportion - Major placenta praevia - Vasa praevia - Cord prolapse - Transverse lie - Acute primary genital herpes - Previous classical C section Relative - Breech - Triplet or higher order pregnancy - 2 or Moe previous low transverse C sections If woman has had a previous C section, IOL can be offered after being assessed by the consultant. Mother should be made aware of increased risk of emergency C section and uterine rupture.
35
What are some methods of induction?
Vaginal prostaglandins - Primary method - Prostaglandins act to prepare the cervix for labour by ripening it, as well as helping the contraction of the smooth muscle of the uterus - Tablet/gel/controlled release pessary - 1 cycle in 24 hours recommended dose Amniotomy - Membranes ruptured artificially with an amnihook - This releases prostaglandins - Only performed when the cervix is ripe - Infusion of artificial oxytocin is given to increase strength and frequency of contractions (start low and titrate up until 4 contractions every 10 mins) - Not used as primary method Membrane sweep - Offered at 40 and 41 weeks to nulliparous women - 41 weeks for multiparous women - Adjunct of IOL - Performing it increases the likelihood of spontaneous delivery - Inserting a gloved finer through cervix and rotating it against foetal membranes aiming to separate the chorionic membrane from the decidua - The separation helps to release prostaglandins Lack of evidence for homeopathy, acupuncture and sexual intercourse.
36
What is the Bishop Score?
Assessment of cervical ripeness. Checked prior to induction and during induction (6 hours post tablet/gel, 24 hours post pessary). - >/=7: cervix is ripe (high chance of response to interventions made to induce labour) - <4: labour unlikely to progress naturally and prostaglandin tablet/gel/pessary will be required Failure of cervix to ripen despite use of prostaglandins may result in the need for a C section
37
What monitoring must be done prior to IOL?
CTG - Reassuring foetal heart rate must be confirmed prior - After IOL, assess via continuous CTG monitoring until normal rate confirmed - Subsequently asses using intermittent auscultation - If oxytocin infusion is started, monitor with continuous CTG throughout labour
38
What are the complications of IOL?
- Failure of induction - Uterine hyperstimulation (contractions last too long or frequent leading to foetal distress, managed with tocolytic agents e.g. terbutaline) - Cord prolapse (can occur at time of amniotomy, especially is foetal head is high) - Infection (risk reduced by using pessary) - Pain (more painful, often epidural analgesia is required) - Increased rate of further intervention vs spontaneous labour (C section, instrumental) - Uterine rupture
39
What are the main classifications fo premature membrane rupture?
PROM (prelabour rupture of membranes) - rupture of membranes at at least 1 hour prior to onset of labour at >37 weeks P-PROM (pre-term prelabour rupture of membranes) - rupture of foetal membranes occurring at <37 weeks
40
What is the pathophysiology of PROM & P-PROM?
Foetal membranes consist of chorion and amnion. they are strengthened by collagen and become weaker (via apoptosis and enzymes) at term in preparation of labour. In PROM and P-PROM a combination of factors lead to early weakening and rupture of the foetal membranes - Early activation of normal physiological processes (higher than normal levels of apoptotic markers and MMPs in amniotic fluid) - Infection (inflammatory markers weaken the membranes) - Genetic predisposition
41
What are the risk factors for PROM and P-PROM?
Smoking Previous PROM/pre-term delivery Vaginal bleeding during pregnancy Lower genital tract infection Invasive procedures Polyhydramnios Multiple pregnancy Cervical insufficiency
42
What are the clinical features of PROM/P-PROM?
Broken waters: painless popping sensation followed by a gush of watery fluid leaking from vagina (Could be gradual leakage or change in discharge) Speculum examination (no need to do if visible leakage) - Fluid draining from cervix and pooling in posterior vaginal fornix - Make sure woman has laid on couch for 30 mins to allow for pooling Lack of vaginal discharge (washed clean): ask woman to cough to see if she expels amniotic fluid
43
What examination should you avoid in suspected PROM/P-PROM?
Digital vaginal examinations - avoid until woman is in active labour
44
What are some differentials for PROM/P-PROM?
Urinary incontinence Normal vaginal secretions of pregnancy Increased sweat/moisture around perineum Increased cervical discharge (infection) Loss of mucus plug Vesicovaginal vaginal fistula
45
What investigations would you want to do to diagnose PROM/P-PROM?
Actim-PROM: swab test looking for IGFBP-1 (concentration is 100-1000x concentration of maternal serum) Amnisure: looks for PAMG-1 (high concentrations in amniotic fluid) USS only used if unclear results (reduced levels of fluid) High vaginal swab: GBS (would indicate abx in labour and give cause for PPROM)