Obstetrics Flashcards
What is pre-eclampsia?
Hypertensive disorder.
Placental disease which can result in catastrophic maternal/foetal compromise.
What is the pathophysiology of pre-eclampsia?
Poor placental perfusion secondary to abnormal placentation.
In normal placentation the trophoblast invades the myometrium and spiral arteries of the uterus destroying the tunica muscularis media.
This renders the spiral arteries dilated and unable to constrict providing pregnancy with high flow, low resistance circulation.
In pre-eclampsia the remodelling of the spinal arteries is incomplete. A high resistance, low flow uteroplacental circulation develops as the constrictive muscular walls of the spiral arterioles are maintained.
This resultant increase in BP combined with hypoxia and oxidative stress from inadequate uteroplacental perfusion leads to a systemic inflammatory response and endothelial cell dysfunction (leading to leaky vessels)
What are the risk factors for pre-eclampsia?
Moderate
- Nuliparity
- Maternal age >40
- Maternal BMI>35
- FHx
- Pregnancy interval >10 yrs
- Mutiple pregnancy
High
- Chronic HTN, HTN, pre-eclampsia, eclampsia in previous pregnancy
- Pre-existing chronic kidney disease
- DM
- Autoimmune diseases (SLE, antiphospholipid syndrome)
Who is offered prophylaxis fro pre-eclampsia?
Women with 1 high RF or >/=2 moderate RFs.
What prophylaxis if offered for pre-eclampsia?
Aspirin 75mg a day.
Continued from 12 weeks gestation until birth.
What 3 criteria must be met for a woman to be diagnosed with pre-eclampsia?
- Hypertension on 2 occasions at least 4 hours apart (Systolic>140, Diastolic>90)
- Significant proteinuria (>300mg in 24 hours urine sample OR >30mg/mmol urinary protein:creatinine
- In a woman >20 weeks gestation
What are the clinical features of pre-eclampsia?
Asymptomatic (therefore BP and urine dipstick should be formed at each antenatal clinic)
- Headaches (frontal)
- Visual disturbances (blurred/double vision, halos, flashing lights)
- Epigastric pain (hepatic capsule distension/infarction)
- Sudden onset non-dependent oedema
- Hyper-reflexia
What are the classifications for pre-eclampsia?
Mild
- BP 140/90-149/99 mmHg
Moderate
- BP 150/100- 159/109 mmHg
Severe
- BP >160/110 + proteinuria >0.5g/day
OR
- BP >140/90 + proteinuria + symptoms
What are some complications of pre-eclampsia?
Onset of pre-eclampsia before 34 weeks is associated with poorer diagnosis.
Maternal complications
- HELLP syndrome (haemolysis, elevated liver enzymes, low platelets)
- Eclampsia (seizures)
- AKI
- DIC
- ARDS
- HTN
- Cerebrovascular haemorrhage
- Death
Foetal complications
- Prematurity
- IUGR
- Placental abruption
- Intrauterine foetal death
What are the differential diagnoses for pre-eclampsia?
Essential HTN (HTN prior to 20 weeks gestation)
Pregnancy induced HTN (New onset HTN presenting after 20 weeks gestation without significant proteinuria)
Eclampsia (Pre-eclampsia & seizures): obstetric emergency
What investigations do you do for someone with suspected pre-eclampsia?
BP
Urine dipstick
24 hour urinary collection
Monitor signs of organ dysfunction (DIC/HELLP)
- FBC (low Hb, low platelets)
- U&Es (high urea, high creatinine, high urate, decreased urine output)
- LFTS (high ALT/AST)
How do you manage pre-eclampsia?
- Prevent development of eclampsia
- Minimise risk of complications for mother and foetus
Monitoring maternal and foetal wellbeing
- BP
- Urinalysis
- Blood tests
- Foetal growth scans
- Cardiotocography
VTE prevention (fluid management & low molecular weight heparin)
Antihypertensives (reduced risk of maternal haemorrhagic stroke, do not alter disease course)
Delivery (the only definitive cure) (prolonging the pregnancy is for the benefit of the foetus alone)
- if <35 weeks and delivery is considered, IM steroids administered to aid development of foetal lungs
What antihypertensives are used in pregnancy?
Severity of HTN correlates to the risk of stroke so it is important to maintain a BP at a level that minimises risk.
1st line: Labetalol (beta-blocker)
- SE= postural hypotension, fatigue, headache, N&V, epigastric pain
- Avoid if woman had asthma/DM
2nd line: Nifedipine (CCB)
- SE= peripheral oedema, dizziness, flushing, headache, constipation
3rd line: Methyldopa (alpha-agonist)
- SE= drowsiness, headache, oedema, GI disturbance, dry mouth, postural hypotension, bradycardia, hepatotoxicity
ACEi are CI in pregnancy due to association with congenital abnormalities.
How does pre-eclampsia resolve?
Following delivery of the placenta.
What post-natal care should the mother receive after suffering from pre-eclampsia?
Monitor mother for 24 hours (still at risk of having seizures, by day 5 they are safe)
BP monitored daily for 1st 2 days, and once 3-5 days post-partum. Need for antihypertensives should be reassessed.
Advise women of risk of developing pregnancy induced HTN and pre-eclampsia in subsequent pregnancies.
What is placenta praevia?
Where the placenta is fully/partially attached to the lower uterine segment.
Cause of antepartum haemorrhage (vaginal bleeding from week 24 of gestation until delivery)
What is the pathophysiology of placenta praaevia?
Minor: placenta is low but does no cover the internal cervical os
Major: placenta lies over the internal cervical os
Low lying placenta is more susceptible to haemorrhage due to a defective attachment to the uterine wall.
Bleeding can be spontaneous or provoked by mild trauma. Placenta may be damaged as the presenting part of the foetus moves into the lower uterine segment in preparation for labour.
What are the risk factors for placenta praevia?
Main RF: previous C section
- High parity
- Maternal age >40
- Multiple pregnancy
- Previous placenta praevia
- Hx of uterine infection (endometritis)
- Curettage to endometrium after miscarriage/termination
What are the clinical features of placenta praevia?
Antepartum haemorrhage (painless vaginal bleeding: spotting/massive haemorrhage)
Pain if woman is in labour
Examination may reveal risk factors.
Uterus not tender on palpation.
How do you assess someone with an antepartum haemorrhage?
Hx
- How much bleeding and when did it start?
- Fresh red/old brown blood/mixed with mucus?
- Could the waters have broken?
- Was it provoked (post-coital)?
- Any abdominal pain?
- Are the foetal movements normal?
- Any risk factors for abruption (smoking/drugs/trauma)?
ABC assessment and resuscitation if significant bleed.
Examination
- Pallor/distress/check cap refill/ cool peripheries
- Abdomen tender?
- Does the uterus feel ‘woody’ or ‘tense’ which may indicate placental abruption?
- Are there palpable contractions?
- Check lie and presentation of foetus
- CTG (>26 weeks) otherwise auscultate heart
- Read pregnancy notes. Scan reports.
Assess bleeding
- Externally
- Speculum exam (avoid until placenta praevia has been excluded by USS)= fresh red/dark, how much, any clots, cervical lesions, cervical dilatation, ruptured membranes
- Triple genital swabs if minimal bleeding
- Digital vaginal examination (do not do this if placenta praevia as can cause massive bleeding, or if membranes have ruptured) to establish whether cervix is beginning to dilate
What are the differential diagnosis for placenta praevia?
Placental praevia is not common.
- Placental abruption (where all/part of the placenta separates from the wall of the uterus prematurely)
- Vasa praevia (fetal blood vessels run near internal cervical os)
- Uterine rupture (full thickness disruption of uterine muscle and overlying serosa, usually occurs in labour with history of previous C section/myomectomy)
- Benign/malignant lesions (polyps/carcinoma/cervical ectropion)
- Infections (BV, chlamydia, candida)
What is the classic triad of Vasa praevia?
- Vaginal bleeding
- Rupture of membranes
- Fetal compromise
Bleeding occurs following membrane rupture when there is rupture of the umbilical cord vessels leading to loss of foetal blood and rapid deterioration in foetal condition.
What investigations would you do if you you suspect major haemorrhage (placenta praevia)?
If major bleeding is suspected, resuscitate and perform investigations simultaneously.
Haematology
- FBC (anaemia)
- Clotting profile
- Kleihauer test (if woman is Rhesus -ve, to determine the amount of feto-maternal haemorrhage and therefore the dose of Anti-D required)
- G&S (if blood group unknown)
- Cross-match (if presentation is likely to warrant an infusion)
Biochemistry (rule out HELLP, pre-eclampsia, organ dysfunction)
- U&Es
- LFTs
CTG (if >26 weeks) to assess foetal wellbeing
Definitive diagnosis: USS (short distance between the lower edge of placenta and internal os)
How do you manage placenta praevia?
Resuscitation A-E approach
Do not delay maternal resuscitation to determine foetal viability.
Can be identified at 20 week USS
- Minor (repeat scan at 36 weeks recommended and placenta likely to moved superiorly)
- Major (repeat scan at 32 weeks and plan for delivery made at this time: elective at 38 weeks)
C section is safest mode of delivery
In all cases of antepartum haemorrhage give anti-D within 72 hours of onset of bleeding if rhesus D -ve