Obstetric Pharmacology Flashcards
Maternal factors that determine transfer of drugs to the fetus include
drug dose route of administration maternal metabolism and excretion maternal protein binding paternal pH and ionisation of drug uterine blood flow
Placental transfer of a drug depends on
weight of the drug
lipid solubility
degree of ionisation
Oxytocin is administered _________ to stimulate ___________________
IV or IM; smooth muscle contraction
What are the side effects of oxytocin?
Hypotension, tachycardia, water intoxication
Ergometrine is administered _________ to stimulate ___________________
IV or IM; SM contraction as well as vascular SM contraction
What are the side effects of ergometrine?
Hypertension, nauseas, vomiting
Why are drugs like oxytocin and ergometrine used in obstetric haemorrhage?
Help the uterus contract and reduce chance of haemorrhage
Pre-eclampsia is experienced by
5-8% of pregnant women
Pre-eclampsia is usually experienced between
> 20 weeks gestation; resolves by 3 months post-partum
What is thought to be the reason pre-eclampsia occurs?
When there is a problem with maternal oxygen delivery to the fetus, the body increases CO and blood flow through other systems that damage her own body but protect oxygen delivery to the fetus
T/F long-term complications of pre-eclampsia resemble those of hypertension in the general population
True - IHD, CVD, HF, CKD, peripheral vascular disease
T/F Ergometrine is contraindicated in pre-eclampsia
True; one of its side effects is hypertension
Why is IV fluid carefully monitored in pre-eclamapsia?
Severe hypertension puts them at risk of pulmonary oedema
What is magnesium sulphate used for in pre-eclampsia?
Prevention and management of seizures
MgSO4 is administered
IV or IM
