Obstetric Drugs Flashcards
Oxytocin indications
Induce labour
Progress labour
Improve frequency and strength of contraction
Prevent and treat postpartum haemorrhage
Placental delivery
Oxytocin receptor antagonist
Atosiban
Atosiban indication
Second line tocolysis in premature labour (nifedipine is 1st)
Ergometrine MOA
Smooth muscle contraction in uterus and blood vessels
Ergometrine use
PPH
Assist with placental delivery (only can be used after baby delivered)
Prostaglandins use
Ripening cervix before delivery
Contract uterine muscles
Misoprostol
Prostaglandin analogue
Medical abortions (alongside mifepristone) IOL Intrauterine fetal death (to deliver baby)
Mifepristone - drug type and indications
Anti-progesterone
Medical abortions - USE FIRST (alongside misiprostol) - ripens cervix
IOL
Intrauterine fetal death (to deliver baby)
Nifedipine
CCB
Reduce blood pressure in HTN and Pre-E
Tocolysis in premature labour
Terbutaline use
Tocolysis in uterine hyper stimulation
Carboprost
Prostaglandin analogue
Stimulates uterine contraction in PPH - GIVE IM
CANNOT BE USED IN ASTHMA
IV magnesium sulphate use
Seizures associated with pre-eclampsia
Neuroprotection up to 34 weeks
What is given first? Mifepristone or misoprostol
Mifepristone (ripens cervix)
Why should NSAIDs be avoided in pregnancy
Can increase BP
Closure of FDA
Ergometrine contraindication
HTN/ eclampsia
Time between maternal steroids
24 hours but can do 12
MgSO4 is given to preterm babies at what week
Less than 34
Steroids are given to mum if baby born under
Less than 36
Sign of MgSO4 toxicity
Reduced RR, reduced BP, absent tendon reflex’s
Terbutaline drug class
B2 agonist
When is the only time terbutaline is used for tocolysis
uterine hyperstimulation from induction
Most common drug for tocolysis
Nifedipine
