obs/gynae Flashcards

1
Q

what happens to total plasma volume in pregnancy

A

increases by around 30-50%

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2
Q

what happens to kidney function in pregnancy

A

increases

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3
Q

what happens to BP in pregnancy

A

biphasic
decreases in early/mid pregnancy
increases in late pregnancy

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4
Q

what is aortocaval compression syndrome

A

compression of the abdominal aorta and inferior vena cava when pregnant woman lies supine

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5
Q

what speculum is used to examine prolapse

A

sims

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6
Q

lifestyle modifications for prolapse

A

weight loss
smoking cessation
reduce caffeine intake
avoid straining/constipation

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7
Q

what type of cells make up detrusor muscle

A

transitional epithelium

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8
Q

where do the sympathetic nerve fibres come off the spinal cord to relax the bladder

A

T11-L2

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9
Q

where do the parasympathetic nerve fibres come off the spinal cord to contract the bladder

A

S2-S4

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10
Q

what receptors are on the detrusor muscle

A

muscarinic M2 and M3

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11
Q

name some anticholinergics

A

oxybutynin
tolterodine
(propiverine, trospium, solifenacin)

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12
Q

side effects of oxybutynin

A

dry mouth
blurred vision
drowsiness
constipation

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13
Q

what class of drugs are given to manage incontinence

A

anticholinergics, antimuscarinics and beta-2 adrenergic agonists

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14
Q

name a beta-3 adrengeric agonist

A

mirabegnon

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15
Q

when is a person said to be in menopause

A

12 months of amenorrhoea
onset of symptoms if hysterectomy

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16
Q

what characterises perimenopause

A

irregular periods and symptoms

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17
Q

what are the central effects of decreased oestrogen levels in perimenopause

A

hot flushes/sweats
joint muscle/pain
low mood + sexual difficulties

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18
Q

what are the local effects of decreased oestrogen in perimenopause

A

vaginal dryness due to vaginal atrophy

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19
Q

non-hormonal medication to treat menopause

A

clonidine

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20
Q

indications for transdermal oestrogen

A

gastric upset e.g. crohns
need for steady absorption e.g. migraines/epilepsy
increased risk of VTE
older women
medical conditions e.g. htn

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21
Q

what is premature ovarian insufficiency

A

menopause <40

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22
Q

how do you diagnose premature ovarian insufficiency

A

FSH > 30 (2 samples more than 4 weeks apart)
4 months of amenorrhoea

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23
Q

medication often used for HRT in breast cancer patients

A

venlafaxine

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24
Q

problems with benzodiazepines in pregnancy

A

associated with cleft palate, neonatal withdrawal syndrome and floppy baby syndrome
avoid in 3rd trimester

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25
potential problem with olanzapine in pregnancy
weight gain and increased risk of gestational diabetes
26
potential problems with risperidone in pregnancy
increased prolactin levels
27
potential problem with lithium in pregnancy
increased risk of abstain anomaly (tricuspid valve) avoid in 1st trimester and when breast feeding
28
what is placenta acreta
when placenta attaches to myometrium
29
what is placenta increta
when placenta invades the myometrium
30
what is placenta percreta
when placenta invades through the myometrium
31
what is an endometrioma
collected old menstrual blood forming a 'chocolate cyst when endometrial tissue grows on or in the ovaries
32
pain treatments for endometriosis
OCP, GnRH agonists to control cyclicality oral progestogens, depot provera, morena coil for glandular atrophy
33
secondary care endometriosis treatment if fertility is desired
ablation excision
34
secondary care endometriosis treatment if fertility is no longer desired
oophorectomy pelvic clearance
35
what is adenomyosis
when endometrial tissue grows into the muscular wall of the uterus
36
how do you treat adenomyosis
hysterectomy
37
what are the 5 different types of uterine fibroids
pedunculated fibroid intracavity fibroid intramural fibroid submucosal fibroid subserosal fibroid
38
what are the 2 indicators of preeclampsia
proteinuria hypertension
39
if a smear shows hPV positive and cytology negative when should a smear be repeated
in 12 months
40
name some associations with hyperemesis gravidum
trophoblastic disease (choriocarcinoma) multiple pregnancies hyperthyroidism nulliparity obesity
41
what does intrahepatic cholestsis of pregnancy present as and what does it put patient at higher risk of
intensive itching risk of still birth (induction offered at 37/38 weeks)
42
when should progesterone bloods be taken in the menstrual cycle to check for ovulation
7 days before next menstrual period
43
when is lactational amenorrhoea a reliable method of contraception?
amenorrhoea baby <6 months exclusively breastfeeding
44
when should initial booking to midwife by made
8-12 weeks
45
when should ECV be offered if baby is breech
36 weeks
46
when should down syndrome screening with nuchal scanning be carried out
11-13+6 weeks
47
if a pregnant woman has a BMI >30, what investigation should she be offered, when and why
oral glucose tolerance test 24-28 weeks test for gestational diabetes
48
how long do baby blues last for
3 days after giving birth
49
what is placenta previa
I - lower segment but not os II - reaches os but doesn't cover it III - covers it but not when dilated IV - completely blocks it
50
what type of ovarian tumour is associated with endometrial hyperplasia
granulosa cell tumours
51
what is the most common type of ovarian cancer
serous carcinoma
52
what can cause a raised AFP in a woman who is pregnant
omphalocele
53
what is HELLP syndrome
severe form of pre-eclampsia haemolysis elevated liver enzyme's low platelets
54
how would a patient with HELLP syndrome present
malaise nausea vomiting headaches
55
3 main causes of bleeding in 1st trimester
spontaneous abortion ectopic hydatidiform mole (molar pregnancy)
56
what are the 3 most common causes of bleeding in the 2nd trimester
spontaneous abortion hydatidiform mole placental abruption
57
what are the 4 likely causes of bleeding in the 3rd trimester
bloody show placental abruption placenta previa vasa previa
58
what are the 3 types of spontaneous abortion
threatened miscarriage missed/delayed miscarriage inevitable miscarriage (complete/incomplete)
59
how would a threatened miscarriage present
painless vaginal bleeding typically around 6-9 weeks
60
how would a missed/delayed miscarriage present
light vaginal bleeding and pregnancy symptoms disappear
61
how would an incomplete inevitable miscarriage present
heavy bleeding and cramps, lower abdominal pain
62
how would a hydatidiform mole typically present
bleeding in 1st/early 2nd trimester exaggerated symptoms of pregnancy uterus may be large for dates Beta HCG may be high
63
how would placental abruption typically present
constant lower abdominal pain woman more in shock than expected from visible blood loss tender, tense uterus normal lie and presentation metal heart may be distressed
64
how would vasa praaevia typically present
rupture of membranes followed by immediate vaginal bleeding fetal bradycardia
65
what is the diagnostic criteria for hyperemesis gravidarum
5% pre-pregnancy weight loss dehydration electrolyte imbalance
66
what is the normal dose of folic acid
400 micrograms
67
what is the higher dose of folic acid given and when
5 milligrams previous child with neural tube defects, on certain anti epileptics, diabetes, sickle cell, thalassaemia, BMI>30
68
what is the first stage of labour
onset of labour until 10cm cervical dilatation
69
what is the 2nd stage of labour
10cm cervical dilatation until delivery of the baby
70
what is the 3rd stage of labour
delivery of the baby until delivery of placenta
71
what is the latent phase of the 1st stage of labour
0-3cm 0.5cm/hour progression irregular contractions
72
what is the active phase of the 1st stage of labour
3-7cm 1cm/hour progression regular contractions
73
what is the transition phase of the 1st stage of labour
7-10cm 1cm/hour progression strong, regular contractions
74
what does the 'show' refer to
mucus plug in cervix falling out and creating space for the baby to move down
75
what is used to treat eclampsia
magnesium
76
3 causes of primary amenorrhoea
- abnormal functioning of hypothalamus/pituitary gland - abnormal functioning of gonads - imperforate hymen
77
what does Kallman's syndrome cause and what is it associated with
hypogonadotrophic hypogonadism anosmia
78
what is the triad (Rotterdam Criteria) for diagnosing PCOS
oligoovulation/anovulation hyperandrogenism polycystic ovaries/ovarian volume >10cm3
79
what is the most common type of ovarian cyst
follicular
80
what are serous cystadenomas
benign tumours of the epithelial cells
81
what are mutinous cystadenomas
benign tumours of the epithelial cells
82
what are dermoid cysts/germ cell tumours
benign ovarian tumours derived from teratomas
83
what are sex cord-stomal tumours
rare - can be malignant or benign several types: - sertoli-leydig cell tumours - granulose cell tumours
84
what is the triad of Meig's syndrome
ovarian fibroma pleural effusion ascites
85
what would be seen on a pelvic ultrasound in ovarian torsion
whirlpool sign free flu in the pelvis oedema of the ovary
86
what is asherman's syndrome
adhesions form in the uterus following damage to it
87
gold standard test for asherman's
hysteroscopy
88
what are Nabothian cysts and what causes them
fluid filled cysts often seen on the surface of the cervix mucus secreted by the endocervix (columnar epithelium) is trapped by the ectocervix (squamous epithelium)
89
what is a rectocele
defect in the posterior vaginal wall allowing the rectum to prolapse into the vagina
90
what is a cystocele
defect in the anterior vaginal wall allowing the bladder to prolapse into the vagina
91
what is a uterine procidentia
prolapse extending beyond the introitus
92
typical treatment for lichen sclerosis
clobetasol
93
what do the upper vagina, cervix, uterus and Fallopian tubes develop from
Mullein ducts (paramesonephria)
94
what is the most and 2nd most common cervical cancer
1st = squamous cell carcinoma 2nd = adenocarcinoma
95
what are the 2 strains of HPV that are responsible for most cervical cancers
16 and 18
96
what 2 proteins does hPV produce and what do they inhibit
E6 and E7 E6 inhibits P53 E7 inhibits pRb
97
what is the most common type of endometrial cancer
adenocarcinomas
98
what is the most common type and sub-group of ovarian cancer
epithelial cell tumours - serous tumours
99
what is a Krukenberg tumour
metastasis in ovary usually from a GI tract cancer - signet ring appearance under microscope
100
most common type of vulval cancer
squamous cell carcinoma
101
most common type of anaerobic bacteria associated with BV
Gardnerella vaginalis
102
what would BV look like under a microscope
clue cells
103
treatment for BV
metronidazole 2g single dose or 400g for 5-7 days (clindamycin as alternative)
104
most common cause of thrush/candidiasis
candida albicans
105
treatment for candidiasis
fluconazole 150 oral single dose
106
what is Lymphogranuloma Venereum (LGV)
affects lymphoid tissue around site of chlamydia (more common in MSM)
107
what are the primary, secondary and tertiary stages of LGV
1 - painless ulcer 2 - lymphadenitis 3 - proctitis
108
treatment for gonorrhoea when sensitivities are known/unknown
not known = IM ceftriaxone known = oral ciprofloxacin
109
what is Fitz-Hugh-Curtis syndrome
complication of PID - inflammation/infection of the liver capsule (Glisson's) = RUQ pain and potentially radiation to right shoulder tipq
110
what is the characteristic sign of Trichomoniasis and how is it treated
strawberry cervix metronidazole 2g single dose or 400g 5-7 days
111
what is given to HIV patients with low CD4 count to protect from PCP
co-trimoxazole
112
what is given during a CS if a woman with HIV's viral load is unknown/high
iV zidovudine
113
what bacteria causes syphilis
treponema palidum
114
what is primary syphilis
painless ulcer (chancre) at site of infection
115
what is secondary syphilis
involves systemic symptoms (Particularly skin and mucous membrane) resolves 3-12 weeks
116
what is an Argyll Robertson pupil
finding in neurosyphilis constricted pupil that accommodates when focusing on a near object but does not react to light
117
treatment for syphilis
deep IM dose of benzathie benzylpenicilin
118
when can the COCP be restarted after childbirth in women who are breastfeeding
6 weeks
119
a COCP containing what hormones is 1st line
(microgynon) levonorgestrel
120
what type of progesterone in COCP is better for pMS
(Yasmin) drospirenone
121
what 2 side effects are unique to the progesterone injection
weight gain osteoporosis
122
medical management of an ectopic
methotrexate
123
medical management of a miscarriage
misoprostol
124
what are the 2 medical treatments given in an abortion
mifepristone misoprostol
125
ultrasound appearance in a molar pregnancy
snowstorm
126
what is the triad of features in congenital toxoplasmosis
intracranial calcification hydrocephalus chorioretinitis
127
treatment for obstetric choleastasis
ursodoexycholic acid
128
what is given to relax the uterus before ECV
terbutaline (subcut)
129
what test is used to determine the dose of anti-D needed
Kleihauer
130
what are the 3 major causes of cardiac arrest in pregnancy
obstetric haemorrhage pulmonary embolism sepsis
131
what is cervical clearage
putting a stitch in the cervix to keep it closed
132
what antibiotic should be given in SROM to prevent chorioamnionitis
erythromycin
133
what is Bishop's score used for, and what 5 things are assessed
determining whether to induce labour - fetal station - cervical position - cervical dilatation - cervical effacement - cervical consistency
134
what Bishop's score predicts a high chance of spontaneous labour
above 8
135
what is McRoberts manoeuvre
in shoulder dystocia hyeprflexion of mother at the hip providing a posterior pelvic tilt
136
what is Rubins manoeuvre
in shoulder dystocia reaching into the vagina to put pressure on the posterior aspect of the baby's anterior shoulder
137
what is woods screw manoeuvre
in shoulder dystocia performed during rubins other hand puts pressure on the anterior aspect of the posterior shoulder. top shoulder pushed forward, bottom shoulder pushed backwards in attempt to rotate the baby
138
what is Zavanelli manoeuvre
in shoulder dystocia pushing baby's head back into the vagina in order to have an emergency CS
139
what is the key risk to the baby in ventouse delivery
cephalohaematoma
140
what is the key risk to the baby with a forceps delivery
facial nerve palsy
141
what is the decision to delivery time for a Cat 1 CS
30 minutes
142
what is the decision to delivery time for a Cat 2 CS
75 minutes
143
what is Johnson manoeuvre
in uterine inversion using hand to push the funds back up into the abdomen, hold for few minutes then administer oxytocin to induce a contraction
144
when can the copper coil or IUS be used following birth
either within 48 hours or after 4 weeks
145
most common bacteria causing mastitis
staph aureus
146
treatment for candida of the nipple
topical miconazole
147
typical pattern of postpartum thyroiditis
thyrotoxicosis - first 3 months hypothyroid - 3-6 months thyroid levels returning to normal within a year
148
what is Sheehan's syndrome
rare complication of pph drop in blood volume leading to avascular necrosis of the anterior pituitary gland
149
what is the presentation of Sheehan syndrome
reduced lactation amenorrhoea adrenal insufficiency/crisis hypothyroidism
150
what is first line medical management for hyperemesis gravidarum
antihistamines e.g. cyclizine
151
what secretes HCG
syncytiotrophoblasts
152
for how long following a termination can pregnancy tests be positive for
up to 4 weeks
153
by what week should a patient be referred to a specialist for lack of fetal movements
24 weeks
154
what is the most common site of an ectopic
ampulla of the Fallopian tube
155
what is the treatment for PID
ceftriaxone followed by doxycycline and metronidazole
156
what is the first line treatment for stress and urge incontinence
urge = bladder retaining stress = pelvic floor muscle training
157
how would an amniotic fluid embolism present
<30 minutes of delivery respiratory distress hypoxia hypotension
158
when should magnesium be stopped for eclampsia
24 hours after last seizure
159
requirements for instrumental delivery to be carried out
FORCEPS - fully dilated cervix - OA position preferably - Ruptured membranes - Cephalic presentation - Engaged presenting part - Pain relief - Sphincter (bladder) empty
160
how long before an IUS is effective
7 days
161
how long before an IUD is effective
immediately
162
how before the POP is effective
2 days
163
how long before the COCP is effective
7 days
164
how long before the implant and injection is effective
7 days
165
how far along in pregnancy would a woman have to be to be diagnosed with pre-eclampsia or pregnancy-induced hypertension
20 weeks
166
first line treatment for fertility issues in PCOS
clomifene
167
treatment for respiratory depression secondary to magnesium sulphate
calcium gluconate
168
criteria for ectopic pregnancies to be managed surgically
>35mm in size and beta HCG > 5000
169
results on combined test indicating higher chance of Downs syndrome
thickened nuchal translucency low pappa - A increased beta HCG
170
what is given to manage PMS is COCP is contraindicated
low dose SSRI
171
if a semen sample is abnormal when should it be repeated
3 months
172
what procedure carries greatest risk of haemorrhage in a newborn if the mother has ITP
prolonger ventouse delivery
173
what procedure carries greatest risk of haemorrhage in the mother if she has ITP
C-section
174
Where would you see a Rokitansky protuberance
teratoma - dermoid cyst
175
why is aspirin contraindicated in breastfeeding
association with Reyes syndrome
176
1st line for primary dysmennorhoea
mefanemic acid
177
where is beta HCG secreted
trophoblastic cells of the blastocyst
178
what is the role of human placental lactogen
- mobilises glucose from fat reserves - diabetogenic to increase nutrient supply to the blastocyst - converts mammary glands into milk secreted tissue
179
what is the only antibody to cross the placenta
IgG
180
when do you give anti-D
28 and 34 weeks
181
what drug stops effect of oxytocin
atosiban
182
what level of the spine is an epidural given
L3-L4
183
3 infectious diseases screened for in pregnant women
HIV Hep B Syphillis
184
what are the 4 baseline parameters on CTG
Baseline foetal heart rate FHR variability number of accelerations number of decelerations
185
what test result is diagnostic for pre-eclampsia
protein creatinine ratio > 30
186
what cell type produces oestrogen
granulosa
187
gold standard investigation for adenomyosis
MRI
188
when should methotrexate be stopped before trying to get pregnant
6 months
189
how is the thyrotoxicosis phase of postpartum thyroiditis managed
propanolol
190
an ectopic pregnancy located where increases risk of rupture
isthmus
191
how long should someone wait before resuming hormonal contraception after taking upsilatte
5 days
192
what would quadruple screening show in Edwards' syndrome
decreased hcg, afp and oestrial normal inhibin
193
what type of tumour is characterised by psammoma bodies on histology
serous cystadenocarcinoma
194
what do you give if a person is HER2 receptor positive breast cancer
trastuzumab
195
what can trastuzumab cause
cardiotoxicity and in turn heart failure
196
what can cause oligohydramnios
PROM renal angenesis IUGR post term gestation pre-eclampsia
197
what should be considered with postpartum continuous dribbling
vesicovaginal fistula
198
investigation for vesicovaginal fistula
urinary dye studies
199
how long do you take folic acid for
first 12 weeks
200
how long do you take vitamin d for
entire pregnancy
201
components of the bishops score
cervical position, consistency, dilation, effacement foetal station
202
treatment for vaginal vault prolapse
sacrocolpoplexy
203
what is a normal foetal baseline rate
110-160
204
what is a normal foetal baseline variability
5-25
205
when is an acceleration/decelartion pathologically abdominal
change in 15 bpm for > 15 seconds
206
what are the causes of non-immune fetal hydrops
severe anaemia (parvovirus B19, alpha thalassaemia major, massive maternal-fetal haemorrhage) cardiac abnormalities chromosomal infection (toxoplasmosis, rubella, CMV, varicella) twin-twin transfusion syndrome in recipient twin chorioangioma
207
when would CVS be carried out
11-14 weeks
208
when would amniocentesis be carried out
15-20 weeks
209
what sign is seen on transvaginal USS in an ectopic
bagal
210
indications for surgical management of an ectopic
>35mm BCG > 5000 fetal heart rate pain/symptoms
211
how long do nulliparous women have to push
2 hours
212
how long do multiparous women have to push
1 hour
213
how long do you have for active management of 3rd stage
30 minutes!!
214
how long do you have for passive management of 3rd stage
1 hour
215
what is the Amsel criteria for BV
3/4 needed white homogenous thin discharge fishy odour clue cells on microscopy ph > 4.5
216
what do you give an oestrogen receptor positive post menopausal woman
anastrazole
217
what do you do with a woman who gets pregnant with stable hypothyroidism
increase levothyroxine by 25mcg
218
how many pulls are allowed on ventouse before c section
3 pulls
219
how often should people with pre eclampsia have their bloods taken
3 times a week
220
what is gold standard for confirming diagnosis of PCP
bronchoalveolar lavage
221
what colour will cancerous cells appear on colposcopy
yellow
222
when should women with gestational diabetes give birth by
40+6
223
how long after a termination can women have a smear
3 months
224
what is the treatment for a Batholian cyst
marsupialisation
225
what is Naegele's rule to calculate EDD
add 1 year and 7 days onto LMP, subtract 3 months
226
order of layers dissected in a c section
skin subcutaneous fat rectus sheath rectus abdominal muscle peritoneum uterine myometrium amniotic sac
227
what is the inheritance of androgen insensiviitvy syndrome
autosomal recessive
228
where is vulval cancer most likely to affect
labia majora
229
signs/symptoms of androgen insensitivity syndrome
primary amennorhoea little to no pubic or axillary hair undescended testes breast development may occur
230
management of lichen sclerosis
topical dermovate
231
which STI would you see colpitis macularis
trichomoniasis
232
what is criteria for RMI
ultrasound scan ca125 menopausal status
233
what is chandelier sign
another name for cervical excitation
234
seen under microscope in syphilis
spirochaete
235
what tests should be done in women under 40 with complex ovarian cyst
Lactate dehydrogenase AFP HCG
236
what type of cancer is someone with lichen sclerosis at slightly higher risk of getting
squamous cell carcinoma of vulva
237
when can you have cervical smear after pregnancy
3 months
238
management of CIN and early stage 1a
LLETZ or cone biopsy
239
management of cervical cancer 1b and 2a
radical hysterectomy and removal of local lymph nodes with chemotherapy and radiotherapy
240
management of cervical cancer 2b-4a
chemotherapy and radiotherapy
241
management of cervical cancer 4b
surgery, chemo, radiotherapy and palliative care
242
treatment of endometrial hyperplasia
mirena continuous oral progesterons
243
how does a complete molar pregnancy occur
2 sperm fertilise an egg with no genetic material
244
how does a partial molar pregnancy occur
2 sperm fertilise normal egg
245
first line for heavy menstrual bleeding
mirena
246
hormonal blood test results for PCOS
Raised LH high LH to FSH ratio
247
when would you induce someone showing signs of eclampsia
more than 34 weeks
248
gold standard for investigating PCOS
transvaginal
249
what could be seen on transvaginal ultrasound in PCOS
string of pearls
250
how do you reduce risk of endometrial hyperplasia and cancer in someone with pcos
Mirena coil induce withdrawal bleed 3-4 months with cyclical progestogens (medroxyprogesterone acetate) or cocp
251
managing hirtuism in pcos
co-cyprindiol (cocp) - stopped after 3 months as increased risk of VTE topical eflornithine (takes 6-8 weeks)
252
when would you take a IUD out in pID
symptoms not resolved in 72 hours
253
what is the process of foetal descent through birth canal
descent engagement flexion internal rotation crowing extension of presenting part external rotation of head delivery
254
what is classed as polyhydramnios
AFI more than 24cm
255
what is classed as oligohydramnios
AFI less than 5
256
what is hypoactive sexual desire disorder
persistent deficient sexual fantasies and desire for sexual activities that causes marked distress and interpersonal issues
257
what is sexual aversion disorder
unwillingness to get involved in sexual activity, with avoidance to any touching or communication that may lead to sexual involvement
258
what is sexual arousal disorder
you're interest in sex may still be there but have difficulty in becoming aroused/maintaining arousal
259
high risk factors for preeclampsia
HTN in previous pregnancy CKD autoimmune disease e.g. lupus DM chronic HTN
260
moderate risk factors for preeclampsia
1st pregnancy >40 pregnancy interval > 10 years BMI > 35 multiple pregnancy FH of preeclampsia
261
when should you take aspirin for preeclampsia and why
12 weeks - gestation 1 high risk factor or 2 moderate
262
when can you try and delay birth
before 24 weeks, history of preterm birth, ultrasound showing cervical length of 25mm or less
263
2 methods of trying to delay birth
prophylactic vaginal progesterone prophylactic cervical cerclage
264
what can you give and when when trying to improve outcome of preterm labour
tocolysis with nifedipine to suppress labour corticosteroids before 35 weeks IV magnesium sulphate before weeks to protect babies brain delayed cord clamping
265
what age is primary amenorrhoea defined as with no other signs of pubertal development
13
266
treatment for mycoplasma genitalium
doxycycline 100mg twice daily for 7 days azithromycin 1g stat, 500mg once a day for 2 days
267
when do you give prophylaxis for VTE from in pregnancy
28 weeks if 3 risk factors 12 weeks if 4
268
when do you carry on VTE prophylaxis for 10 days
BMI>40 c section admission > 3 days any surgical procedure any medical co morbidities