Obs and Gynae Flashcards

1
Q

Obs and Gynae Hx Checklist

A

PC and HPC
- Gynae: relationship of symptoms to menstrual cycle
- Obs: EDD and LMP. PLanned pregnancy? Assisted conception? Complications so far? tests and results so far?
Important symptoms:
Gynae
- Bleeding: Menarche, LMP, cycle length, days of bleeding, regular cycle? Bleeding between periods (PCB, IMB, PMB)? Menorrhagia? dysmenorrhoea? Discharge? Clots? flooding? menopause?
- Sex: Currently sexually active? Dyspareunia (superficial or deep)?
- Contraception: Current method? Happy with it?
- Smears: When was last one? was it normal? ever had an abnormal smear? How was that investigated?
- STIs: Ever been tested for one? Ever positive? how was it treated? Symptoms (itching? burning? discharge? (colour? smell?)
- Urogynae: Frequency? Urgency? Incontinence (stress vs urge)? Prolapse (heavy feeling of uterus inside vagina)
Obs:
- Gravidy and parity
- Planned pregnancy
- Assisted or natural conception
- How far along currently? Tests and results? any complications?
- For Previous pregnancies:
- Planned pregnancy?
- Did it reach term? if not what happened
- Complications in pregnancy, labour, birth (how delivered and birth weight)
- How is mum and baby now (post-natal depression)?
- Same partner each time? consanguinity?
- Plans for future pregnancies
PMHx
DHx - esp folic acid for pregnancy
FHx:
- Gynae: Cancer (especially bowel or breast are associated with gynae), VTE, Clotting/bleeding disorders (recurrent miscarriage)
- Obs: Complications during pregnancy (Pre-eclampsia, diabetes, miscarriage), Twins or multiple pregnancy
SHx
- support network at home? domestic abuse? EtOH? Smoking?
ROS
- Gynae: Bowel or Bladder symptoms? any other abdo or pelvic symptoms.
- Obs: Headache, RUQ pain, nausea (pre-eclampsia)
- Itching hands and feet (cholestasis of pregnancy)

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2
Q

Obstetrics: Examination

A

1) General inspection
- Anaemia? Jaundice? Hydration (vomiting?), Oedema, BMI
2) Abdominal inspection
- Is there an abdominal mass consistent with pregnancy?
- Striae, excoriations, scars, linea nigra, fetal movements
3) Symphasis-Fundal height
- Back of tape measure, go from pubic symphysis to fundus.
- Between 24-36 weeks, height in cm should be no. of weeks +/- 2cm
- 12 weeks: palpable at pelvic inlet. 20 weks: palpable at umbilicus. 36 weeks: Palpable at xyphisternum
4) Abdominal palpation
- Keeping one hand still, “ballot” down other side, feeling for baby’s back. do this on both sides
- Then feel near pelvic inlet if late stages for engagement
- Foetal lie (vertical/horizontal/oblique), presentation (cephalic or breech) and fifths engaged
- If too easy to feel baby: Oligohydramnios. If too tense and difficult to feel baby: polyhydramnios.
5) Foetal heart beat
- Listen over baby’s anterior shoulder (usually midpoint between mother’s ASIS and pubic symphysis) with pinard stethoscope or Sonicaid
6) Maternal Pule, BP, urinalysis

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3
Q

Gynae: examination

A

1) General inspection
- Anaemia, Jaundice, Hydration (vomiting), Oedema, BMI
2) Abdominal inspection
- Scars (umbilical, pubic hair line), masses, tenderness
3) Speculum examination
- Consent, wash hands, gloves, exposure
- Sim’s speculum to look at vaginal walls (vaginal atrophy or prolapse)
- Cusco’s speculum to look at cervic and fornices (warts, ectropion, neoplasia, polyps, trauma, liquor)
- Pt’s feet together & towards bottom, knees bent, then slowly drop knees to either side
- Inspect vulva for bleeding, trauma, discharge
- Lubricate speculum, place on posterior fourchette with handle pointing sideways
- warn patient, then insert speculum, rotating and opening as you go in so the handle points upwards
- Visualise cervical os (open/closed)
- Visualise fornices
- Take smear if needed at this point: brush goes into external os, rotate 5x, then put in labelled bottle for liquid based cytology
- Also take any required swabs at this point
- Remove speculum, inspecting vaginal walls on way out
- Inspect the speculum for blood or discharge
4) Bimanual
- Warn patient, insert 1 gloved, lubricated finger into the vagina, followed by another
- Feel the cervix for cervical excitability. Palpate fornices for any masses or tenderness
- With other hand on abdomen, palpate the uterus for size, shape (ante/retroverted), mobility, tenderness)
- Remove fingers, inspect for blood or discharge

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4
Q

Swabs: Types, indications and conditions/results

A

1)High vaginal swabs
Candida albicans
- Thick white, curd-like discharge. Filaments on microscopy
- Rx: clomitrazole cream OR oral fluconizole
Bacterial vaginosis
- Whitish/clear discharge, fishy smell, pH<4.5, clue cells on microscopy, whiff test +ve
- Rx: Metronidazole or clindamycin cream
Trichomonas vaginalis
- green discharge, strawberry cervix. Flagellated protozoa on microscopy
- Rx: Metronidazole

2)Endocervical swabs
Chlamydia trachomatis
- Often asymptomatic. Nucleic Acid Amplification Tests (NAATS) via urine
- Rx: Stat. azithromycin followed by oral doxycycline (unless pregnant, sue erythromycin instead of doxy)
Neisseria gonorrhoea
- Often asymptomatic, can get purulent discharge + PCB. Gram negative diplococci seen on microscopy
- Rx: Ceftriaxone

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5
Q

Cervical screening: Procedure, results, follow-up/Rx

A

UK smear programme:
- If 25-49YO, smear recommended every 3 years
- If 50-65YO: smear recommended every 5 years
- If >65YO: Smear only done if previous abnormalities found or if never previously had a smear test
Smear looks for abnormal cell divisions (dyskaryosis), using liquid based cytology, taking cells from the transitional zone
Abnormalities looked for:
- Abnormal mitotic figures
- Abnormal nucleus:cytoplasm ratio
- Clumping of chromatin
- Pleomorphism

Results

  • Normal - routine follow up (as per above)
  • Insufficient/inadequate - Repeat smear in 3/12
  • Borderline dyskaryosis - HPV test and if positive, colposcopy
  • Mild dyskaryosis - HPV test and if positive, colposcopy (mild dyskaryosis usually but not always corresponds to CIN I (Cervical Intraepithelial Neoplasia) on colposcopy
  • Moderate dyskaryosis - colposcopy (usually corresponds to CIN II on colposcopy)
  • Severe dyskaryosis - colposcopy (usually corresponds to CIN III on colposcopy)

If colposcopy is positive (CIN I, II or III), repeat smear and HPV in 6 months)

Management:

  • CIN I: watch and wait, usually returns to normal spontaneously
  • CIN II or III: LLETZ procedure (Large Loop Excision of Transitional Zone)

History

  • Last smear date, results
  • LMP?
  • Reason for smear? as it taken correctly? by who? (GP, OPD)
  • Currently pregnant, postnatal (<12 weeks), IUD? taking hormoned?
  • Was cervix visualised during procedure
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6
Q

Urogynae (Incontinence and prolapse)

A

Incontinence
Stress incontinence
- Weak bladder neck –> incontinence on activity
- Rx: Lose weight, stop smoking, pelvic floor exercises, surgery (Tension-free Vaginal Tape)
Urge incontinence
- Involuntary detrussor activity –> day and night incontinence
- Rx: Avoid caffiene, bladder retraining, anti-cholinergic drugs (oxybutynin), botox

Prolapse:

  • Anterior (cystocele), posterior (rectocele) or apical (uterovaginal or vault)
  • Symptoms: General (Vaginal mass, dyspareunia, Abnormal bleeding) or specific (bowel/bladder symptoms for rectocele/cystocele respectively)
  • Rx: Conservative: Pelvic floor exercises, ring pessaries
  • Surgical: Apical: Sacrocolpopexy (abdominal approach) or sacro-spinous ligament fixation(vaginal approach)
  • Surgical: Anterior/posterior: wall repair
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7
Q

Definition & Stages of Labour

A

Definition: Onset of regular, painful contractions leading to progressive effacement and dilation of the cervix
Stage 1
- Latent: Onset of contractions to full effacement of the cervix
- Active: Full effacement of cervix to full dilation of the cervix (10cm)
- Augmentation of labour is inefficient during the latent phase
Stage 2
- Full dilation of the cervix to delivery of the baby
Stage 3
- Delivery of the baby to delivery of the placenta
- Routine use of syntometrin during stage 3 reduces PPH by 50% (should occur within 30 mins)
- Physiological 3rd stage (no drugs) - PPH should occur within 60 mins
- For either, CCT (Controlled Cord Tension) is used, guarding the uterus always to prevent inversion

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8
Q

Cardiotocography (CTG) Checklist and Indications

A

Checklist: DR C BRAVADO

  • Define Risk (indications)
  • Contractions
  • Baseline RAte
  • Variability
  • Accelerations
  • Decelerations
  • Overall
Indications
Maternal
 - Previous C-section
 - Pre-eclampsia
 - Significant maternal disease (e.g. diabetes)
 - >42 weeks
 - Prolonged rupture of membranes
 - Antepartum haemorrhage
Foetal
 - Pre-term
 - Oligohydramnios
 - Intrauterine growth restriction
 - Breech
 - Multiple pregnancy
 - Meconium stained liquor
Intrapartum
 - Oxytocin
 - Epidural
 - Maternal pyrexia
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9
Q

Cardiotocography (CTG): Interpretation

A

Contractions
- Height of line DOES NOT MEAN strength of contraction
- Should see 4 every 10 mins in active labour
- More frequent contractions (tachysystole) suggests uterine hyperstimulation, may cause foetal distress
Baseline rate
- Should be 100-160bpm
- Tachycardia: Maternal pyrexia, foetal hypoxia or infection, exogenous beta agonists (e.g. salbutamol), prematurity
- Bradycardia: could be severe foetal distress due to placental abruption or uterine rupture. Foetal hypoxia, foetal hypotension, post maturity, maternal sedation
- Acute, prolonged change in rate sugegsts acute foetal distress
Variability
- Should be at least 5bpm
- Reduced variability could be due to sleep (<45min), early gestation, drugs (BD, opiates)
- Long term reduced variability –> foetal hypoxia
Accelerations
- >15bpm above baseline for >15s
- Usually normal and seen with contractions
Decellerations
- >15bpm below baseline for >15s
- Early: begin with contractions and end when contractions end. Normal reaction to head compression. Usually uniform in size, shape
- Variable: begin and end in variable timing with contractions. Classically reflect cord compression
- Late: begin with contractions but persist after contractions. suggestive of foetal hypoxia

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10
Q

CTG: Overall and Rx

A

1) Baseline rate
- Normal: 100-160bpm
- Non-reassuring: 161-180bpm
- Abnormal: <100bpm or >180bpm
2) Variability
- Normal >5bpm
- Non-reassuring: <5bpm for 30-90mins
- Abnormal: <5bpm for >90mins
3) Decellerations
- Normal: None or early decellerations
- Non-reassuring:
- Variable decellerations <60bpm (below baseline) for <60s for >90 mins on >50% of contractions
- Variable decellerations >60bpm OR >60s for 30-90mins on >50% of contractions
- Late decellerations for <30mins on >50% of contractions
- Abnormal
- Non-reassuring decellerations, not responding after 30mins of conservative measures, >50% of contractions
- Late decellerations >30mins, not responding to conservative measures, >50% of contractions
- Bradycardia/single deceleration of >3 mins
Overall: CTG is normal if all 3 catergoies are normal, non-reassuring if 1 is non-reassuring and 2 normal, Abnormal if 1 is abnormal or 2 are non-reassuring

Rx:

  • Non-reassuring CTG: Conservative measures: Left lateral position, monitor BP, HR, Temperature. Give fluids PO/IV, stop oxytocin
  • Abnormal: Conservative measures + foetal blood sampling
  • Single deceleration >3 mins: Conservative measures. If no response within 9 mins of start of brady: expedite delivery

Foetal blood sampling - if indicated but impossible: expedite delivery

  • pH>7.25 & trace is still abnormal, repeat in 60s
  • pH7.2-7.25: repeat in 30 mins
  • pH<7.2: expedite delivery
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11
Q

Routine antenatal care appointments: First trimester

A

ASAP: First visit to healthcare professional
- Give information on:
- Folic acid (400mcg/day or 5mg/day if high neural tube defect (NTD) risk (e.g. previous NTD, on anti-epileptic medication, sickle cell disease)
- Increase vit D intake (Pregnacare has both)
- Nutrition & diet, food hygiene, smoking & ETOH
- Antenatal screening, risks and benefits
- Screen for domestic abuse/social circumstances, FGM
<10 weeks: booking appointment
- Booking BP, BMI, Risk for pre-eclampsia and GDM
- Info on antenatal screening, risks and benefits
- Pelvic floor exercises
- Pregnancy care plans, where and how to deliver, breastfeeding, antenatal classes, maternity benefits
- IF SHE WANTS ANTENATAL SCREENING:
- Bloods (anaemia, haemoglobinopathies, red cell alloantibodies, Hep B, HIV, syphilis serology, bloood group and RhD status)
- Urine: dipstick and MC&S for UTI, haematuria and asymptomatic bacteruria
- Dating and anomily scans
- Down’s risk (and other chromosomal tests): Combine test at 10-14 weeks, also triple or quadruple tests
10-14 weeks: Dating scan
- Gestational age, viability, nuchal translucency, multiple pregnancy

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12
Q

Routine antenatal care: second triemster

A

16 weeks
- Discuss previous tests and results
- BP, Proteinuria, OGTT if previous GDM
- Consider Fe supplementation if anaemic
18-20 weeks: Anomily scan
- Looks for physical abnormalities, foetal growth, liquor volume, placental position
- Repeat at 32 weeks if placenta is low
25 weeks (NULLIPAROUS WOMEN ONLY)
- BP, proteinuria, Symphasis-fundal height

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13
Q

Routine antenatal care: third trimester

A

28 weeks
- BP, proteinuria, SFH (Symphasis-fundal height)
- OGTT if GDM risk but no previous GDM
- Bloods (screening for sickle cell and RBC alloantibodies)
- Give first dose of anti-D to RhD negative women
31 weeks (Nulliparous only)
- BP, proteinuria, SFH
- Discuss 28 week results
34 weeks
- BP proteinuria, SFH
- Discuss 28 week results
- Second dose of Anti-D for RhD negative women
- Info on preparation of labour & pain control
36 weeks
- BP, proteinuria, SFH
- Check foetal lie, confirm abnormal lie on USS
- Offer external cephalic version for uncomplicated, singleton breech
- Info on breastfeeding technique, baby care, vit K prophylaxis and newborn screening
- Info on maternal care, post-natal depression, baby blues
38 weeks
- BP, proteinuria, SFH
- Specific information on management of prolonged pregnancy
40 weeks (Nulliparous only)
- BP, proteinuria, SFH
- Further discussion of management options for prolonged pregnancy
41 weeks
- BP, proteinuria, SFH
- Offer membrane sweep/induction of labour
42 weeks
- BP, proteinuria, SFH
- Offer induction of labour OR increased monitoring (2x/week CTG and USS for max amniotic fluid depth)

Maternal wellbeing is monitored by vitals: BP, HR, Temperature, SpO2
Foetal wellbeing is monitored by continuous CTG monitoring or intermittent monitoring

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14
Q

Quantifying/screening for post-natal depression

A

Edinburgh post-natal depression scale

  • 10 questions, important woman fills it out herself, based on what she’s been feeling in the last 7 days
  • Important not to discuss her answers with anyone as she fills it out
  • Each question is scored from 0-3 (either 0=not at all and 3=always/very often or other way round, 3 is worst)
  • Max score - 30, score of 10 or more is possible depression. Always look at the answer for Q10 (self harm)

Questions:

1) I have been able to laugh and see the funny side of things
2) I have been looking forward with enjoyment to things
3) I have blamed myself unnecessarily for things that went wrong
4) I have felt anxious or worried for no good reason
5) I have felt scared or panicky for no good reason
6) Things have been getting on top of me
7) I’ve felt so sad I’ve had difficulty sleeping
8) I’ve felt sad or miserable
9) I’ve felt so sad I’ve been crying
10) The thought of harming myself has occurred to me

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15
Q

Perinatal mortalitiy: definitions and causes/risk factors

A

Definitions
- Miscarriage: death <24 weeks gestation
- Stillbirth: death >24 weeks gestation
- Neonatal death: death <28 days after birth
- Early: 0-7 days, Late: 8-28 days
- Perinatal mortality: sum of neonatal death and still births per 1000 births
Causes
- Commonest: Antepartum stillbirth
- Common: Pre-eclampsia, foetal abnormalities, intrapartum hypoxia, antepartum haemorrhage
- Rare: Infection, trauma, foetal/maternofoetal haemorrhage
Risk factors
- Age <17 or >40
- Asian or Afro Caribbean race
- poor nutritional status
- Smoking, EtOH or recreational drugs
- Medical illness
- Multiple pregnancy
- Multiparity

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16
Q

Maternal mortality: Definitions, stats and causes

A

DEFINITIONS:
- Maternal death: Death of mother <42 days after delivery, directly caused by pregnancy or indirectly aggrevated by pregnancy
- Late maternal death: As above, but between 42 days and 1 year after delivery
- Direct: caused directly by pregnancy or obstetric complications
- Indirect. Caused by increased physiological stress during pregnancy PLUS some other underlying disease which may have begun during pregnancy (e.g.g GDM) or not
STATS
- UK maternal mortality = 9/100k live births
- Africa maternal mortality = 510/100k live births
CAUSES
Indirect:
- Heart disease (commonest cause of death outside pregnancy anyway), other medical disease
Direct
- Amniotic fluid embolism
- Thromboembolism
- Hypertensive disease
- Haemorrhage
- Anaesthetic related
- Post-natal depression/suicide
- Fatty liver of pregnancy
- Ectopic pregnancy
- Genital tract sepsis

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17
Q

Abortion Law

A

Abortion act 1967
One can abort a pregnancy if it falls under one of these categories:
A) Continuing the pregnancy is more dangerous to the mother’s life than abortion
B) Abortion is necessary to prevent grave, permanent physical or mental injury to the mother
C) Continuing is more likely to cause injury to the physical or mental health of the mother than abortion
D
) continuing is more likely to cause injury to the physical or mental health of the mother’s other children than abortion
E) The baby is likely to be born with a serious physical or mental handicap
*C and D have a time limit of 24 weeks, all others have no time limit
Each case requires 2 doctors to agree on the use of the abortion act

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18
Q

Fraser guidelines and Gillick competence

A

Fraser guidelines refer specifically to guidance on prescribing contraception to those under 16.
Gillick competence refers to how we assess whether someone under 16 has the capacity to consent to medical treatment
Fraser guidelines:
- doctor can prescribe contraception/offer advice to under 16 year olds, without parental consent, if the following 5 criteria are met
1) Child can understand your advice
2) Unable to convince the child to inform their parents
3) The child is likely to continue to have unprotected sex otherwise
4) Not giving contraception will likely cause the child physical or mental harm
5) Prescribing without parental consent is in the child’s best interests

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19
Q

Obstetric cholestasis (symptoms –> Rx)

A

Signs/symptoms:
- Itchy hands and feet during pregnancy
- Pruritus without rash
- Causes increased risk of spontaneous preterm labour or foetal death
Diagnosis
- Raised LFTs and/or bile acids
- Once diagnosed, weekly LFTs until birth
Treatment
- No evidence for any specific treatment
- Induction of labour @ 37 weeks to reduce chance of stillbirth

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20
Q

Amniotic fluid embolism (symptoms –> Rx)

A
Symptoms/signs:
 - Acute SoB + hypotension 
--> cardiorespiratory failure &amp; coagulopathy
--> convulsions
--> coma
Diagnosis
 - Clinical diagnosis
Management
 - Emergency
 - Stabilise the mother ASAP
 - C-section ASAP
 - CPR, and if unsuccessful, do abdo delivery
 - O2, intubate, more CPR if needed
 - Monitor foetus
 - Treat coagulopathy with FFP, cryoprecipitate and platelets
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21
Q

Pre-eclampsia: Symptoms –> Rx (NOT severe)

A

Signs/symptoms:
- HTN, headache, RUQ/epigastric pain, nausea, blurred vision
- Can progress to HELLP syndrome or eclampsia
Diagnosis
- BP>140/90, at least 1+ proteinuria
- headache, swelling of face, hands, feet, blurred vision
Investigations
- If these symptoms are increasing, suggests severe pre-eclampsia
- Admit for urinalysis (MC&S), 24hr urinary protein
- Bloods (FBC, U&E, LFTs, renal function)
Rx:
- Only definitive treatment is delivery. No need to deliver before 34 weeks unless haemodynamically unstable
- USS foetus (growth, amniotic fluid volume, doppler of umbilical arteries)
- GTC
- Mild (BP 140/90-149/99): 4x daily BP and 2x weekly bloods (LFTs, U&Es, FBC)
- Moderate (BP 150/100-159/99): as above, 3x weekly bloods and BP control (labetolol or nifedipine if contraindicated, e.g. asthma)
- Severe: As above, but >4x daily BP
- Repeat CTG if lack of foetal movements, vaginal bleeding, abdo pain or disorientation

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22
Q

Severe pre-eclampsia and eclampsia: Rx

A

Severe pre-eclampsia:
- Consider antihypertensives at lower BP threshold if there are other symptoms
- MgSO4: used to prevent seizures if worried about them, also used to treat seizures. 4g stat loading dose over 5-10 mins, followed by 1g/hr infusion. Can increase to 1.5-2g/hr if needed. Keep giving until 24hrs after last seizure
- Fluid restrict to 80ml/hr
- Consider early delivery, before 34 weeks with corticosteroids. Consult senior support
Eclampsia
- Left lateral position
- High flow O2
- May need intubation to preserve airway
- Management as above, delivery is more important, usually ASAP

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23
Q

Placenta praevia

A

Signs/symptoms
- Painless PV bleed in late pregnancy
- Increased risk of preterm delivery
Diagnosis
- High index of suspicion for any PV bleeding in late pregnancy
- USS shows leading edge of placenta. Suspicious cases confirmed by transvaginal USS
- Further TV US done for all women with low lying placenta on anomily scan
- @36 weeks for minor placenta praevia
- @32 weeks for major placenta praevia
Management:
- Minor: may deliver vaginally, unless leading edge <2cm from os. C-section @ 38 weeks
- Major: Needs C-section.
- If not bleeding: Careful counselling about outpatent care vs admision.
- Bleeding: Admit @ 34 weeks
- C-section done @ 38 weeks, unless placenta accreta is suspected, in which case deliver @ 36-37 weeks
- In acute bleed, DO NOT perform a vaginal exam

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24
Q

Placental abruption

A

Signs/symptoms:
- Acute, severe abdominal pain and PV bleed in late pregnancy
- Woody hard uterus
- 20% concealed (most severe, bleed reains inside uterus)
- 80% revealed
- May cause maternal collapse, foetal hypoxia or death
Diagnosis
- Clinical diagnosis
Management
- High flow O2
- FBC, Kleihauer test (foetal haemoglobin in maternal bloodstream), X-match 4 units of blood, left lateral position, keep mother warm
- If foetus is alive: C-section OR artificial rupture of membranes
- If foetus is dead: vaginal delivery, unless C section needed to control the bleeding
- If there’s time, give corticosteroids for foetus’ lungs

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25
Q

Uterine rupture

A

Signs/symptoms
- Acute, severe abdo pain and PV bleeding in labour
- If epidural: sudden maternal hypotension and foetal hypoxia
- Most occur in women who’ve had previous C-sections
Diagnosis
- Can be diagnosed before labour on USS (abnormal foetal position, haemoperitoneum, abnormally thin uterine wall)
Rx:
- Urgent delivery (usually surgical) and resuscitation as needed
- Uterine repair if possible, or hysterectomy if bleeding is uncontrolled
- 20% of uterine repairs will rupture again
- 6.2% associated with perinatal death

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26
Q

Shoulder dystocia

A

Shoulder damage of foetus due to traumatic birth
Rx (Prevention)
- Get MDT approach for difficult deliveries (get help of anaesthetist and paediatrician)
- Stop mother pushing, reduce downward traction on foetal head
- McRobert’s manoeuvre (hyperflex and adduct maternal hips against abdomen)
- Failing that, episiotomy and 2nd line manoeuvres

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27
Q

Cord presentation/prolapse

A

Cord presentation: umbilical cord below presenting part.
Cord prolapse: umbilical cord below the presenting part AFTER rupture of membranes
- Most cord presentation DOES NOT become cord prolapse
Diagnosis
- Clinical diagnosis
Management (overt prolapse)
- High flow O2, knee-chest position, facing bed
- avoid handling the cord
- urgent C-section or vaginal only if fully dilated and no contraindications
- Sub-cut terbutaline to reduce contraction if there is a delay in C-section
Management (occult prolapse)
- left lateral position, high flow O2
- Monitor foetal heart rate (CTG)
- If foetal heart rate is normal, keep monitoring
- If becomes abnormal –> C-section urgently

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28
Q

Post partum haemorrhage

A

Definitions:
- Primary = <24hrs after delivery. Secondary = 24hrs-12weeks
- Minor = 500-1000ml, Major > 1000ml
Rx (minor)
- IV access, bloods (FBC, Group & Save, coagulation screen)
- warmed crystalloid infusion
- Vital obs every 15 mins
Rx (Major)
- ABC, position flat and keep warm, transfuse ASAP if needed (so bloods: FBC, G&S, Coagulation screen)
- Infuse warmed isotonic crystalloid up to 3.5l
- Don’t use special blood filters as they slow infusion
Blood transfusion
- No specific guidelines on when to transfuse, best clinical and haematological judgement
- Give O-ve, K-ve blood until correct blood group is known
- FFP may be useful if 4 units RBS given or known/suspected coagulopathy or continued bleeding
- Platelets to keep plt>75, cryoprecipitate to keep fibrinogen>2g/l
MDT approach, anaesthetist to keep haemodynamically stable
Rx (Secondary PPH)
- Vaginal microbiology (endocervical and high vaginal swabs)
- Pelvic USS to exclude retained products of conception, this will need experienced surgical removal

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29
Q

Pulmonary embolism

A

Signs/symptoms
- Acute SOB, pleuritic chest pain, tachycardia, hypoxia –> cardiac arrest
Investigations
- ECG, CXR
- If no VTE symptoms: CTPA or VQ scan
- If VTE symptoms: Compression duplex USS
Rx (PE or DVT):
- low molecular weight heparin
Rx (life threatening PE)
- Treat on individual basis
- Unfractionated heparin (IV) and thrombolytic therapy OR
- Thoracotomy and surgical ebmolectomy
- MDT approach (Obstetricians, radiologists, senior physicians)
- Elastic stockings, leg raising and mobility should be encouraged

30
Q

Ectopic pregnancy (+ruptured ectopic)

A

LIF/RIF pain in any woman if childbearing age, think ectopic until porven otherwise
Signs/symptoms:
- beta-HCG: Confirms pregnancy at all
- Trans-vaginal USS: Criteria differ dependign on where the ectopic is (most commonly in the Ampulla of the fallopian tube)
Management
- Expectant: first line for first 7-14 days unless Hx of obstetric complications, evidence of infection or increased risk of haemorrhage
- Surgical: Manual vacuum aspiration (done as outpatient under local anaesthetic)
- Surgical: Laparoscopical surgical removal in theatre under general anaesthesia. Usually do a unilateral salingectomy unless thee’s other fertility concerns
RUPTURED ECTOPIC
- Pearly pregnancy, pelvic pain + shoulder tip pain. PV bleeding, collapse.
- Rx: As above, more urgent. May need some resuscitation

31
Q

Ovarian cyst tortion/rupture

A

Signs/symptoms
- Severe pelvic pain w/hypovolaemic shock
Diagnosis
- USS: best diagnostic test. Trans-vaginal is more sensitive than abdominal
- Also pregnancy test to rule out ectopic
Rx (ovarian tortion):
- Laparoscopic uncoiling of ovary + possible oophoroplexy (fixing ovary to abdominal wall) if indicated)
- Salpingo-oophorectomy may be needed if severe vascular compromise, peritonitis or tissue necrosis
Rx (cyst):
- Immediate surgical intervention needed for haemorrhagic cyst

32
Q

Cervical carcinoma

A

Signs/symptoms
- Abdormal bleeding (esp IMB and PCB)
Diagnosis
- Cervical screening can diagnose and treat up to CIN 3 (see that card)
Investigations
- Test for chlamydia
- Colposcopy +/- cone biopsy
- FBC, U&E, LFT, CT CAP to look for mets
Definitions and staging
- Breaching the epithelial basement membrane = invasive cancer
- <5mm invasion = micro invasive. >5mm invasion or >7mm wide needs formal staging
- Stage 1: Confined to uterus
- Stage 2: Spreads beyond uterus, not affecting lower 1/3 of vagina or pelvic wall
- Stage 3: Affects lower 1/3 of vagina or pelvic wall or alters renal function
- Stage 4: Further spread
Management:
Surgical
- Radical cervicectomy (trachelectomy) for women with stage 1a wanting to preserve fertility
- Laparoscopic hysterectomy + lymphadenectomy for those women not wanting to preserve fertility (stage 1a)
- For stages 1b/2a: Radical hysterectomy and lymphadenectomy
Radiotherapy
- Recommended by cochrane review for all stages of cervical cancer, usually Brachytherapy combined with external beam therapy
- For stage 2b-3: no evidence of added benefit to surgery on top of radiotherapy
Chemotherapy
- Given to most with cervical cancer, either adjuvantly with radiotherapy or palliative.
- Most commonly cisplatin (platinum)

33
Q

Endometrial carcinoma

A

Signs/symptoms
- Abnormal bleeding, especially PMB
Diagnosis
- Transvaginal ultrasound: Endometrial thickness >3mm =high risk
- Biopsy high risk cases for definitive diagnosis
Staging/grouping
- Stage 1: Limited to corpus uteri
- Stage 2: spread to cervical stroma
- Stage 3: Local/regional spread beyond lymph nodes
- Stage 4: Involvement of bladder/bowel/distant metastases
- Group 1: <5% non-squamous cells
- Group 2: 5-50% non-squamous cells
- Group 3: >50% non-squamous cells
Management
- Progestogen can preserve fertility in stage 1a
- Stage 1: total abdominal hysterectomy with bilateral salpingoophorectomy
- Stage 2: Radical hysterectomy with systemic pelvic lymph node clearance
- Stage 3-4: Maximal debulking surgery, usually with radio and chemotheray

34
Q

Ovarian carcinoma:

A

Signs/symptoms
- Fairly non-specific: abdo pain, distension, abnormal bleeding, weight loss
Investigations
- Ca 125, if >35, then abdo USS
- If abdo USS is suggestive of cancer, urgent referral
Classification _+ Staging
- 90% are epithelial tumours (>50YO), 5-10% are germ cell tumours (<35YO)
- Tumours may be benign, malignant or borderline
- Stage 1: Affects ovary only
- Stage 2: Affects one or both ovaries w/pelvic extension
- Stage 3: Microscope confirmed implants outside pelvis
- Stage 4: distant mets
Management
- Surgery is best, poor response to chemotherapy
- Exploratory laparotomy for histological confirmation, staging and tumour debulking
- Followed by adjuvant chemotherapy (Paclitaxel & Carboplatin, IV every 3 weeks for 6 cycles)

35
Q

Pelvic Inflammatory Disease

A

Signs/symptoms
- Pelvic pain, PV bleeding, abnormal discharge, fever
- Nausea and vomiting, dyspareunia
- 75% get mucopurulent discharge. 5% Fitz-Hugh-Curtis syndrome (pleuritic RUQ pain due to hepatic capsule adhesions)
Risk factors
- Young, sexually active, high prevalence STI areas, not using condoms
- 200k casesyr in UK
Investigations
- Pregnancy test (rule out pregnancy). If PID + pregnancy, admit
- Endocervical swabs for gonorrhoea and chlamydia (negative doesn’t rule out PID but positive supports it as these usually cause PID)
- Laparoscopy is the best diagnostic tool but is invasive and not always appropriate
- ESR, CRP, urinalysis
- USS can exclude other things
Management
- Mild-moderate: primary care or outpatient
- Severe: Admit and IV antibiotics
- Current antibiotic recommednations: IM stat ceftriaxone (500mg), twice daily metronidazole (2 days) + twice daily doxycycline (2 weeks)
- Oral doxycycline for male partners for gonorrhoea prophylaxis
- Adequate analgesia
- Consider GUM referral
- May also need to drain tubo-ovarian abscess (TOA)
- Ruptured TOA needs emergency surgery. Bilateral salpingoophorectomy w/hysterectomy is best but consider wishes for future fertility
- Infertility, chronic PID and ectopic pregnancy are all long term complications

36
Q

Important maternal infections

A

TORCH (Toxoplasmosis, Rubella, CMV, Herpes simplex)

- Also VZV and Listeria

37
Q

maternal Toxoplasmosis

A

Maternal
- usually asymptomatic, occasionally flu-like symptoms
Spread
- Only acute toxoplasmosis infection can spread in 10% of cases (10% have clinical evidence of disease)
Foetal
- Abortion, intracranial calcification, hepatosplenomegaly, chorioretinitis, convulsions
Management
- Prevention: Avoid cleaning cat litter trays and poorly cooked meat
- Rx: Sulphadiazine and pyrimethiamine

38
Q

maternal Rubella

A

Maternal
- Mild rash, arthralgia, lymphadenopathy
Foetal
- Congenital Rubella Sydrome:
- Deafness, cateracts, PDA, IUGR, mental retardation
Diagnosis
- IgM or big rise in IgG
Management
- Only prevention. Give MMR to non-immune people (e.g. kids)

39
Q

maternal CMV

A

Maternal
- Often asymptomatic. Sometimes mild viral disease (like glandular fever), rarely hepatitis
Foetal
- CMV inclusion disease): Hepatosplenomegaly, intracranial calcification, chorioretinitis, low IQ, interstitial pneumonitis, hearing loss
- 30% mortality
Transmission: Bodily fluids/sex
High seroreactivity (>50%) = hard to diagnose
No Rx or vaccine available

40
Q

maternal Herpes simplex

A

Maternal
- Primary: Fever, arthralgia, painful genital lesions, lymphadenopathy
- Recurrent: painful lymphadenopathy
Foetal
- Viral sepsis, herpetic skin and moth lesions, herpes encephalitis, diseminated infection (causes neurological problems and high mortality)
Transmission by direct contact
Prevention
- C-section if primary, debated if recurrent
Management
- Propylactic acyclovir may prevent active lesions in labour

41
Q

maternal VZV

A

Maternal
- chickenpox. 10-70% get pneumonitis, meningitis (rare), shingles
Foetal: Congenital Varicella syndrome:
- If exposed <20 weeks: Chorioretinitis, cerebral cortical atrophy, hydronephrosis, long bone defects
- exposure near term: benign chickenpox. Full diseminated infection can be fatal
Transmission is airbourne, highly infectious
Diagnosis: Serology + clinical suspicion
Prevention: consider VZIg or acyclovir. Only 5% of mothers are susceptible
Management
- Avoid delivery during acute infection
- VZIg +/- acyclovir may be helpful for the neonate

42
Q

maternal Lysteria

A
Maternal
 - Often asymptomatic, Flu-like symptoms, fatigue, rarely meningitis
Foetal
 - Early onset: neonatal sepsis
 - Late onset: meningitis
Transmission: Unpasteurised milk/cheese
Diagnosis
 - Cervical + blood culture
Management
 - Ampicillin + gentamycin
43
Q

Small baby for dates

A

CAUSES:
Smoking/EtOH
Maternal illness/infection
Pre-eclampsia (on another card)
Oligohydramnios:
- Suspected if small SFH
- Confirmed by USS: Amniotic fluid volume <300ml, lack of single >2cm vertical pocket, AFI<5 at term or size <5th centile
- Caused by loss of fluid (PROM) or decreased production (congenital renal abnormality or ACEi exposure, uteroplacental insufficiency (placental abruptio or pre-eclampsia), congenital infection, cardiac defects, neural tube defects
- Management: Obvious structural defect may sometimes be amenable to in utero surgery. Otherwise, consider early delivery and may infuse crystalloid into amniotic cavity

44
Q

Large for dates

A

POLYHYDRAMNIOS
- Suspected if big SFH
- USS shows AFV>2000ml, single verticle pocket >10cm, AFI >20cm, >95th centile size for age
Causes
- Idiopathic (50%), rarely placental chorangioma (rare)
- Maternal causes (GDM, isoimmunisation –> immune hydrops fetalis)
- Foetal causes: non-immune hydrops fetalis due to cardiac defect, multiple pregnancy, structural abnormalities (GI obstruction, lung deformities_, foetal DI
Management
- Options are limited
- NSAIDs (indomethacin) reduces foetal urine output but can cause early ductus arteriosus closure
- Removing fluid only works short term
- Centralised amniotomy during labour reduces complications from rapid decompression (placental abruption, cord prolapse)
GDM
Screening
- Risk factors (high age, ethnicity (African, Asian, Latin American), high BMI, weight gain between pregnancyes, famHx of GDM, T2DM, smoking
- OGTT to diagnose (@ 16 weeks if previous GDM, 28 weeks if high risk)
Maternal complications
- Polyhydramnios, C-secion in 20-60%, pre-eclampsia, chronic HTN or T2DM, DKA, pre-term birth
Foetal complications
- congenital abnormalities (cardiac, renal, GI, skeletal, neuro), spontaneous abortion, DKA, IUGR, foetal macrosomia +/- birth trauma
Management
- Diet (36kcal/kg/day, 40-50% CHO, 20% protein, 30-40% fat)
- Insulin therapy & regular BM monitoring (aim for <5.2)
- Eye exam each trimester
- Detailed foetal structural screen (USS and echo) @ 18-22 weeks
- USS for growth at 32 weeks to look for IUGR
- C-section may be indicated if baby is large

45
Q

Chorionic villous sampling and amniocentesis

A

CVS

  • Done usually abdominally, sometimes trans cervically
  • Samples placenta for foetal karyotyping
  • 10+0-13+6 weeks, 5% of women approx (increased risk of miscarriage)
  • Give anti-D to RhD -ve women
  • Looks for chromosomal abnormalities in high risk women

Amniocentesis

  • Done abdominally, after 14 weeks
  • Samples cells from amniotic fluid, again for karyotyping
  • Done in 5% of women (high risk for chromosomal abnormalities)
  • COnsent for small miscarriage risk, PV bleeding, amniotic fluid leakage
  • Also assesses for neural tube defects, bilirubin (haemolysis), lung maturity and enzyme analysis (inborn errors of metabolism)
46
Q

Other screening tests

A

‘Combined test’

  • done at 11-14 weeks
  • USS for nuchal translucency. Bloods for b-HCG and PAPP-A
  • Tests for Down’s, Edward’s, Patau’s

Serum triple test

  • Done at 14-20 weeks
  • Bloods for AFP, b-HCG, Oestradiol
  • Tests for Down’s (high bHCG, low AFP/Oestradiol = high risk), and spina bifida

Quadruple test

  • Done at 15-22 weeks
  • Bloods for AFP, bHCG, Oestradiol, Inhibin A
  • Looks for chromosomal abnormalities and spina bifida
47
Q

Causes of antepartum haemorrhage

A

Placental abruption or placenta praevia (both mentioned in separate cards)

48
Q

Preterm labour

A

Onset of labour before 37 weeks
Four main possible mechanisms/causes
- Stress (maternal e.g. depression, foetal e.g. IUGR, DM, pre-eclampsia)
- Stretch (excessive uterine stretch, due to multiple pregnancy or polyhydramnios)
- Infection (intra-uterine infection)
- Haemorrhage (decidual haemorrhage, e.g. placental abruption)
- Preterm PROM is also an important cause 9more in another card)
Investigations
- Prediction is difficult, many tests (risk factor assessment, uterine monitoring, infection/edocrine markers). Much of this shows poor diagnostic value
Management
- Firm diagnosis of preterm lablour (uterine contractions and cervical effacement and dilation)
- Tocolytics (absolute CI include intrauterine infection, foetal distress, vaginal bleeding, intrauterine foetal demise. Relative CI include PROM)
- Bed rest and hydration
- Short term tocolytics are cornerstone of Rx (none are shown to delay labour by >48hrs). CCBs are first line, e.g. nifedipine. b-agonists also used but more side effects for mum. MgSO4 has wide safety margin and is neuroprotectve for babies under 1500g.
- Using one drug is preferable
- Progesterone support from 16-36 weeks may prevent pre-term delivery in some high risk cases

49
Q

Reduced foetal movements

A

Causes
- foetal sleep, maternal obesity, oligo/polyhydramnios
- Foetal conditions (neuro/musculoskleletal malformations, foetal anaemia)
- anterior placenta, IUGR
Investigations
- USS and CTG to identify any serious issues

50
Q

Premature rupture of membranes/pre-term premature rupture of membranes

A

Premature ROM (PROM): rupture of fetal membranes before labour
Preterm premature ROM (PPROM): PROM <37 weeks
- Prolonged PROM: PROM >24hrs, increases risk of intra-amniotic infections
- After PROM, 50% into labour within 12hrs, 70% within 24hrs, 85% within 48hrs and 95% within 72hrs
Diagnosis
- Clinical diagnosis
- Amnio-due test to confirm & differentiate from vaginal discharge or urine leakage
- Also confirmed by pH 7-7.7 (vaginal pH is usually 4.5),
- microscopic ferning appearance of fluid when drying
Aetiology
- Caused by focal weakness in near term in foetal membrane, over internal os. pathological processes like infections or bleeding can complicate
- Risk factors: Prior PPROM, unexplained PV bleeding, placental abruption, cervical insufficiency
Management
- PROM: Immediate inductio nof labour +/- cervical ripening OR expectant management
- if CI (Active labour, foetal distress, unexplained PV bleeding, chorioamnionitis), immediate delivery and Abx if needed
- PPROM: depends on gestational age. Risk of prematurity vs risk of expectant management
- <32 weeks: admit, regular GTC, USS, monitor for infections, broad spectrum Abx, antenatal corticosteroids
- 32-34 weeks: ?Abx to increase latency. ? atenatal corticosteroids
- >34 weeks: Consider delivery if infection risk outweighs prematurity risk

51
Q

Post term pregnancy

A

Defined as >42 weeks

  • @38 weeks, give information on options to manage prolonged pregnancy (membrane sweeping at 41 weeks, expectanr management)
  • Offer induction at 41-42 weeks
  • Vaginal PGE2 as gel or tablet or pessary is preferred method of induction. Repeat dose in 6hrs if labour not induced
  • If this fails, further attempt or C-section, discuss with mother
  • Perinatal mortality (complared to 40 weeks) is 2x @ 42 weeks, 4x # 43 weeks and 5-7x @ 44 weeks
  • Meconium aspiration, neonatal acidaemia, low Apgar score, macrosomia and birth trauma all increased
  • Maternal: Chorioamnionitis, severe perineal lacerations, PPH and endomyometritis increase
52
Q

Malpresentation

A

Definitions
- Breech: Presenting buttock’s first.
- Frank breech (70%): feet up by head
- Complete breech (20%): legs crossed
- Footling or incomplete breech (one foot presents first)
- Compound presentation: Extremity presents along with presenting part
Diagnosis
- Leopold manoeuvre, vaginal exam or USS
Risk factors
- Prematurity, uterine abnormality, polyhydramnios, orior breechg, multiple gestation, placenta praevia
Symptoms
- Causes increased risk of congenital abnormality, cord prolapse, preterm labour and birth trauma
Management
- ECV at 36 weeks (CI: uterine abnormality. Relative CI: prior C section, IUGR, twins)
- Frank breech more successful with ECV (approx 50% success)
- Breech delivery: C-section usually if pre-term, usually abdominal if term
- Vaginal delivery may be a safe option if frank breach, experienced operator, low risk & capacity to switch to emergency C-section

53
Q

Mode of delivery councelling

A

Normal vaginal unless CI
Surgical vaginal done if:
- Exhaustion
- HTN and advised not to push
- weak contractions
- Need to speed up for baby
- Episiotomy done, usually repaired with sutures
Assisted vaginal
- Forceps or vaccume, same indications as above
- Can have foetal complications, such as scalp lacerations or cephalohaematoma)
C-section
- Low, transverse most commonly, Heals stongest and least blood loss
- Complications: Bleeding, infection (esp diabetic, obese or emergency C-section), injury to foetus, injury to adjacent organs
- Possible need for hysterectomy due to blood loss, or bowel repair post delivery

54
Q

Maternal GBS infection

A

Can be asymptomatic (80%) or UTI, chorioamnionitis, endomyometritis
Foetal
- early onset –> sepsis, 6-12hrs after birth. 80% transmitted during birth
- Late onset –> meningitis, community acquired >7 days after birth
Prevention
- Treat in labour if risk factors (Prev GBS, GBS UTI, preterm, ROM >18hrs)
- Rx: Intrapartum penicilin or vancomycin if allergic

55
Q

Hypertensive diseases in pregnancy

A

Chronic HTN: likely if BP >140/90 <20weeks (probably just went undiagnosed)
Pregnancy induced hypertension: BP>140/90 in 3rd trimester, WITHOUT proteinuria. Rarely causes adverse outcomes
Pre-eclampsia: Discussed in another card
HELLP Syndrome: Combination of Haemolysis, Elevated Liver enzymes and Low Platelets
- Occurs as a complication of pre-eclampsia
- Higher risk if >35YO, nulliparous, previous HTN in pregnancy or HELLP, multiple pregnancy, caucasian
- Haemolysis is due to MAHA (Schistocytes),
- LDH>600, raised AST or ALT, low PLT, high Bilirubin
Management of HELLP
- If <34 weeks, delivery is deferred to give corticosteroids
- MgSO4 considered, as is RBCs, Platelets, FFP and cryoprecipitate if needed
- Postpartum HELLP: Give plasma exchange
- If severe, liver transplant may be needed
- BP control is essential

56
Q

Diabetes in pregnancy

A

Chronic DM: Ideally women should be seen before conception, diabetic control correlates with foetal outcomes
- Regular HbA1c to monitor
- Normal labour and delivery if good glycaemic control
- C-section if likely macrtosomia
-In labour: IV glucose and insulin infusions needed as women may not eat for a long time
Gestational diabetes
- Maternal complications: Little risk, avoid iatrogenic hypoclycaemia. 50% will get GDM in future pregnancies and around 50% will get chronic DM later in life
- Foetal comlpications: If poorly controlled, foetal macrosomia (birth trauma), risk of congenital abnormalities and spontaneous abortion
Management
- Diabetic diet (36kcal/day, 40-50% carbs, 20% protein, rest fat)
- Oral antihyperglycameics (metformin)
- C-section may be needed and usually no further Rx necessary
- OGTT 6-8 weeks post partum as a screening test for underlying or new chronic DM

57
Q

Epilepsy in pregnancy

A

Any seizure in pregnancy = epilepsy until proven otherwise. Could also be due to trauma or infection

  • Risk to baby is low if not exposed to anti-epileptics in periconception period,
  • 1 drug is better than 2 or more
  • 5mg folic acid/day up to end of firstt trimester at least
  • Sodium valproate can have neuro effects, as can carbamezapine
  • Epilepsy increases risk of hyperemesis, pre-term delivery and pre-eclampsia
  • Hence balancing risks to mum and baby is important
58
Q

HIV in pregnancy

A

1.5-2% of MCTC occurs transplacentally, rest in birth or breastmilk
- Without intervention, 15-45% of mothers will pass on HIV. With intervention this drops to 1%
Risk factors
- Primary HIV contracted during pregnancy
- High viral load, low CD4
Management
- ART during antenatal period, elective C section, avoid breastfeeding
- Pre-eclampsia, cholestasis or other liver problems suggest toxicity to medications. Urgent referral to HIV specialist

59
Q

Causes of PV bleeding, abdomiunal pain, N&V during pregnancy

A

Miscarriage, ectopic, molar pregnancy
Hyperemesis gravidarium
- persistent vomiting –> fluid loss and electrolyte disturbance, weight loss, ketonuria + nutrient deficiency
- Rx: replace nutrition and electrolytes, promethiazine if severe
- Medical: UTI, pylonephritis, gastroenteritis
- Surgical: Renal colic, appendicitis

60
Q

Types of miscarriage

A

Threatened
- Slight pain and bleeding
- O/E: Os closed, foetus still alive, bleeding
- 25% will miscarry
Inevitable
- Pain + heavier bleeding
- O/E: Os open.
- Miscarriage is inevitable
Incomplete
- Considerable pain + bleeding
- O/E: Os open, some foetal parts passed
- Rx: Surgical evacuation +/- Im ergometrine
Complete
- Bleeding deminished
- O/E: os closed, foetus passed, uterus not enlarged
- Rx: Nil. IM ergometrine if further bleeding uncontrolled
Missed
- Detected on USS or bleeding
- O/E: Os closed, death in utero, small for dates
- Rx: Surgical evacuation
Molar pregnancy
- Hyperemesis gravidarium OR no symptoms
- O/E: Enlarged uterus for dates. Snow storm appearance
- Rx: Surgical evacuation and follow up
Ectopic
- Pain, some bleeding. O/E: Os closed (see other card for Rx)
Risk factors
- PID, prior ectopic, prior tubal surgery, prior infertility, current IUD
- Usually occurs in fallopian tube
- Dx: bHCG> should double every 48hrs in normal pregnancy
- Trans Vaginal Ultrasound to confirm
Management
- Expectant for clinically stable women with decreasing bHCG, initially <1500
- Medical: methotrexate suitsable if viable intra-uterine pregnancy has been ruled out
- Surgical: laparoscopic preferred, salpingectomy >salpingotomy (risk of trophoblast left behind), if other tube is healthy and no fertility issues.
- Otherwise salpingotomy (risk of trophoblast left behind, checked for with bHCG measurements

61
Q

Abnormal bleeding: Causes and diagnosis and Rx

A

Organic causes: Reproductive tract
- Pregnancy related (ectopic, miscarriage, implantation bleeding about the time of first missed period)
- Uterine lesions –> menorrhagia or metrorrhagia
- Cervical lesions (due to trauma or erosion) can cause metrorrhagia, esp PCB
- Iatrogenic (IUD, oral/injectable steroids for contraception)
Organic causes: Systemic disease
- Bleeding disorders
- Hypothyroid (menorrhagia + other abnormal bleeding)
- Cirrhosis –> excessive bleeding (liver unable to metabolise oestrogens)
Dysfunctional (endocrine causes) - rule out organic first
- Ovulatory: Up to 10% of ovulatory women. Mid cycle spotting following LH surge. usualy physiological, due to shorter follicular phase or longer luteal phase (persistent corpus luteum)
- Anovulatory
- Main type in ovulatory women, due to neuro-endocriine altered function
- Continuous oestradiol production without corpus luteum formation and progesterone release. Unopposed oestradiol –> proliferation of endometrium which is irregular and outgrows blood supply
Diagnosis
- Rule out pregnancy related, full drug Hx to rule out drug causes
- Full physical exam to rule out ssytemic causes
- Serum Hb and FBC to check objective blood loss
- Further evaluation of uterus (non-pregnant): endometrial biopsy +/- hysteroscopy
- Hysteroscopy can also be therapeutic (endometrial ablation, polypectomy, submucosal myomectomy
Management
- Majority medically (esp if lack of structural lesion)
- Oral contraceptives workl for anovulatory and ovulatory causes, however acute haemorrhagic presentation requires short term high dose oestrogen to support endometrium
- NSAIDs (Mefenamic acid) reduces blood loss in ovulatory patients
Surgical Rx
- Dilation and curettage for acute bleed fue to endometrial overgrowth
- Hysteroscopy as day procedue and therapeutic (e.g. endometrial ablation, can decrease cyclic blood loss)
- Hysterectomy as last resort if structural lesions not amenable to more conservative approach

62
Q

Menopause

A

Definition: permanent cessation of menstruation for 12 months
- Average age 51.5
- Early: smoking, hysterectomy
Perimenopause:
- Symptoms: weight gain (esp lower abdo, buttocks, thighs), 4-5yrs of varying cycle length before menopause
Hormones during perimenopause
- Elevated FSH (less inhibition), normal oestradiol and LH (varies)
After menopause
- Almost no oestrogen from ovaries (small amount from androgens from adrenals)
- 10-20x increase in FSH (causing increased androgens), 3x increase in LF (peaks 1-2yrs post menopause)
- Hypooestrogenic changes cause symptoms/issues
Symptoms
1) Vasomotor (hot flushes in 70% of perimenopausal women, less intensity and frequency with age)
2) Osteoporosis
- Oestrogen slows bone resorption, >2.5 standard deviations below peak adult bone density = osteoporosis (1-2.5sd below = osteopenia)
- 50% of >75YO have vertebral fractures, 25% o f>80YO have had hip fractures
- Risks: low BMI, smoking, Euro/Asian ethnicity, FHx of osteoporosis
- Rx: Bisphosphonates
3) Genital atrophy:
- Tissues of lower vagina, labia, urethra are all oestrogen dependent
- Dyspareunia, vaginismus, dysuria, urgency, incontinence
4) Mood: Fatigue, anxiety, irritability, headaches, insomnia, depression
Management: HRT
Benefits
- Treats all 4 symptoms above, some evidence of lower risk of Alzheiners, osteoarthritis, colon cancer
Risks
- More risk of endometrial hyperplasia and adenocarcinoma unless progestogens added (not needed if prev hysterectomy)
-Higher risk of breast cancer if used long time
Side effects
- Nausea, erratic vaginal bleeding, headaches, breast tenderness
Regimens
- Premarin (cyclic conjugated equine oestrogen) 0.1mg on days 1-25 of the month, Provera 10mg on days 13-25
- Premarin 0.05mg transdermal and prosera 2.5mg daily
- Vaginal pessaries or patches also exist
- Botanicals (e.g. st. john’s wort) may help vasomotor symptoms short term but little evidence and drug interactions are a problem
- Compliance is a big issue. Main benefits are long term (e.g. osteoporosis) and concerns of breasrt cancer and clots put people off

63
Q

Vaginal discharge: Non-infective

A

Physiological
- Translucent white/clear, odourless
- Oestrogen turns it from sticky & thick to clearer, wetter and stretchy
Ectropian
- Columnar epithelium migrates down cervical canal to replace squamous
- Causes IMB, PCB, increased discharge
- High risk if: teenage, COCP, HRT
- Rx: Reassure, may need diathermy or cryotheraoy
Neoplasia (Cervical polyp)
- Benign tumour in 4th-6th decade. Increased bleeding throughout (IMB, PCB, menorrhagia)
- Rx: leave if asymptomatic. D&C, hysteroscopic polypectomy + hystology if causing problems
Foreign body
- Offensive, serosanguinous discharge
- Rx: Speculum exam and remove foreign body
- Toxic shock syndrome can be caused by group A strep (Fever, widespread rash, nausea and vomiting, desquamation of hands and feet. Rx: Abx, fluid resuscitation, may need ITU and vasopressors
Fistula
- Discharge is flatus, faeces or urine. ?infective
- Rx: Abx and abscess drainage.Surgical repair

64
Q

Vaginal discharge: Infective

A

NON STI
Bacterial vaginosis
- Usually caused by gardnerella vaginalis
- Clear/whitish fishy smelling discharge.
- pH>4,5, clue cells on microscopy
- Rx: Metronidazole 400mg 5 days OD plus metronidazole cream
Candidiasis
- Thick, white, curdy discharge. yeasty smell
- Itch and external dysuria and dyspareunia
- Vulval oedema on examination
- Microscopy shows fungi with hyphae
- Rx: PO 150mg fluconazole stat (unless pregnant). PV clomitrazole
STI
Trichomonas vaginalis
- Green/yellow frothy offensive discharge. Strawberry cervix. Dyspareunia, dysuria and vulvitis
- Microscopy shows flagellated protozoa
- Rx: Stat or 5 days metronidazole
Chlamydia trachomatis
- Discharge, dysuria, lower abdominal pain, fever, IMB, PCB, deep duspareunia
- 70% asymtpomatic
- Endocervical swab + NAAT.
- Rx: 1g stat azithromycin and 7 days BD oral doxyxycline or erythromycin if pregnant
Neisseria gonorrhoea:
- 50% asymptomatic
- Mucopurulent discharge, contact bleeding, dysuria.
- Microscopy shows gram negative diplococci
- Endocervical swab with charcoal medium
- Rx: IM ceftriaxone. many also co-infected with chlamydia
PID: mentioned in another card

65
Q

Acute pelvic pain

A

Gynae causes - rule out infections or pregnancy. Imaging is helpful
- Ectopic pregnancy or miscarriage (crampy midline pain): do pregnancy test
- Acute PID - fever, nausea, pain, discharge
- Ruptured ovarian cyst: Severe pain, usually self limiting
- Ovarian torsion (or any adnexal mass torsion): often associated with hypovolaemic shock)
- Degenerating fibroids or ovarian tumours: localized, sharp pain
Non gynae causes
- Mesenteric lymphadenitis (follows URTI, diffuse, milder pain)
- Appendicitis: Central pain, moves to right lower quadrant + low fever, anorexia, leukocytosis
- Diverticulitis: older women, left sided pain, bloody diarrhoea, leukocytosis, fever
- UTI or renal colic: Suprapubic pain, pressure and dysuria

66
Q

Chronic pelvic pain

A

Gynae (Laparoscopy for diagnosis usually, hysterectomy usual Rx)
- Dysmenorrhoea: Primary - due to excess prostaglandins from uterus, Secondary: sue to endometriosis. oral contraceptive + NSAIDs help
- Endometriosis: Ranges from dysmenorrhoea to constant, severe pain. Pain severity doesn’t correlate with disease severity
- Fibroids: Pain due to degeneration or pressure on other organs
- Ovarian remnant syndrome: Persistent pelvic pain post removal of both adnexae. Cystic portion of ovary is often to blame
- Chronic PID: due to pelvic adhesions, persistent hydrosalpinx of tubo-ovarian cysts
- Prolapse - heaviness, drooping, pelvic ache
- Adenomyosis: Enlarged boggy uterus, mildly tender to bimanual exam. Rx: hysterectomy
Non gynae
- GI (E.g. IBD)
- MSK (Muscle strain or disk hernia)
- Interstitial cystitis
- Somatoform disorders

67
Q

Subfertility: Definitions and initial tests

A

Infertility: inability to conceive after >12 months of trying in women <35 (or 6 months if woman is >35)
Fecundability = probability of getting pregnant in a given monthly cycle. usually 20-25% (=85-90% in 1 year)
10-15% of reproductive age married couples are infertile
Risk factors
- Age >35, smoking, drug use, some onvironmental/occupational exposures
Diagnosis
- Full Hx from both partners (including previous children from both, duration of attempts, timing, woman’s prior pelvic surgery or infections)
- Confirm normal/predictable ovulation (timings, urinary LH kits, basal Temperature)
- Physical examination: Endocrine (hirsutism, hepatomegaly, thyromegaly) or gynae (fibroids, endometriosus)
- Tests:
- Endo (day 3 FSH, oestradiol), TSH, prolactin
- Hysterosalpingogram for female, semen analysis for male
- FBC, Viral infections (HIV, Hep B/C, Rubella, VZV)

68
Q

Causes of infertility and Rx

A

FEMALE (50%)
Ovarian (20%)
- Hx: secondary amenorrhoea or irregular menses.
- O/E: Hirsutism, obesity, galactorrhoea, lean build if hypothalamic amenorrhoea
- Ovulation timings from history and urine kids to see LF surge/daily temperature measurements
- Ovarian reserve assessed with day 3 FSH, oestradiol. Rx if no ovulation: ovulation induction
- Hypothalamic amenorrhoea: low LH/FSH, low oestradiol, Rx: give GnRH
- PCOS: Normal LH/FSH and oestradiol. Rx: Clomiphene citrate
- Ovarian failure: raised FSH/LH, low Oestradiol. Rx: Eg donation
Tubal + positional (20%)
- Hx: often prior pelvic infection or ectopic pregnancy. Secondary dysmenorrhoea or cyclic pelvic pain suggests endometriosis
- Dx: Hysterosalpingogram (HSG): contrast through cervix into uterus and peritoneal cavity to exclude polyps, fibroids.
- Laparoscopy is gold standard, can exclude adhesion sand endometriosis
- Rx: Tubal surgery (tuboplasty) or IVF
Cervical (10%)
- Hx: prior cervical surgery (cone biopsy, courettage), or infection
- O/e: Cervical lesions/abnormalities
- No reliable screening tests
- Rx: Intra-uterine insemination (IUI)
MALE (35%)
- Hx: testicular injury, infection, chemo/radiotherapy, genitourinary surgery
- Common idiopathic oligosperima
- Erectile/ejaculatory dysfunction, tobacco/drug use
- O/E: Hypospadias, varicocele, cryptorchidism, atrophic testes
- Dx: semen analysis (2-3 days abstinence beforhand), if abnormalities (motility, morphology, concentration), repeat in 4 weeks
- Rx: Surgery for varicocele, IUI or IVF +/- Intracytosplasmic sperm injection (ICSI)
IDIOPATHIC (15%)
- All above excluded
- Rx: Ovulation induction + IVF or IUI

69
Q

Contraception measures: no user error

A

No user error (i.e. woman doesn’t have to remember to do something every day or every time she has sex)
Contraceptive injection
- contains progestogen, >99% effective, lasts 8-12 weeks. Non reversible
Implant
- Small, flexible implant placed under skin in upper arm. Requires small procedure to install.
- Releases progestogen, >99% effective. Lasts 3 years but can be removed early if needed
Intra-uterine system (IUS): Small, T shaped plastic device inside uterus, releases progestogen
- >99% effective
- Lasts 5 years (can remove early)
- Periods become lighter and shorter but irregular bleeding is common for the first 6 months
Intra-uterine device (IUD)
- Small, copper and plastic device into uterus. >99% effective
- Lasts 5-10 years, can be removed sooner
- Causes heavier, longer, more painful periods
Sterilisation
- Fallopian or sperm tubes but, sealed or blocked. 1/200 women or 1/2000 men fail. NOT removable but no long term side effects (no medication)

70
Q

Contraception measures (some user error)

A

Some user error, woman has to think about and do something regularly each time she has sex
Patch:
- Releases oestrogen and progesterone, >99% effective and makes periods lighter and shorter and less pain
- May cause skin irritation
- Each patch lasts one week. 3 weeks on, 1 week off
Contraceptive vaginal ring
- Small, flexible plastic ring inserted into vagina. Releases oestrogen and progesterone
- >99% effective, also makes periods lighter
- Stays in 3 weeks, removed for 1 week. must be comfortable putting it in and out herself
Combined Oral Contraceptive Pill (COCP)
- Oestrogen and progesterone pill
- 99% effective, makes lighter periods
- Take 1/day for 3 weeks, 1 week off (must take same time each day), some pills taken every day
- Missing pills, vomiting and diarrhoea make the pill less effective
Progesterone Only Pill (POP)
- Only contains progesterone, >99% effective
- Can be used by >35YO, smokers, breastfeeding women.
- Missing pills, diarrhoea or vomiting make it less effective
Male condom
- 98% effective if used properly (right size etc)
- Can slip off or break
Female condom
- Thin plastic sheath, loosely covers vagina and just outside
- 95% effective but not as widely available
Diaphragm/cap
- Latex/silicone device, covers cervix
- also used with spermicide
- 92-96% effective. Needs more spermicide if you have sex again
Natural family planing
- Fertile and unfertile times noted by monitoring fertility markers (LH surge, Temperature)
- Up to 99% effective with proper teaching
- abstinence or condoms needed for fertile times
- No chemicals/drugs so no side effects