OBS Flashcards

1
Q

What is the risk of placenta accreta in the presence of a previa and 0, 1, 2, 3, 4 CS

A

Previa and:

  • 0 prior CS: 3 %
  • 1 prior CS: 25 %
  • 2 prior CS: 40 %
  • 3 prior CS: 61 %
  • 4 prior CS: 67 %
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2
Q

What is the risk of placenta accreta in the absence of placenta previa

A

Accreta without previa

  • 1 prior CS: 6.6 %
  • 2 prior CS: 17%
  • > 3 prior CS: 55%
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3
Q

What is the risk of accreta with 1 prior CS and with and without previa

A

One previous CS

  • No previa: 6.6%
  • Previa: 25%
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4
Q

What is the risk of accreta with 2 prior CS and with and without previa

A

Two (2) previous CS

  • No previa: 17%
  • Previa: 40%
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5
Q

What is the risk of accreta with 3 prior CS and with and without previa

A
  • No previa: 55%
  • Previa: 61%
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6
Q

Name the indications for aspirin in pregnancy (10)

A
  • AMA (Age > 40)
  • ART
  • BMI > 30
  • History of IUGR
  • History of PET
  • Chronic HTN or previous GHTN
  • Multiple pregnancy
  • DM 1 or DM2
  • History of placental abruption
  • History of placental infarct
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7
Q

When should ASA be started

A

12- 16 weeks

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8
Q

What is the mechanism of action of labetolol

A

Mixed alpha + beta adrenergic ANTAGONIST

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9
Q

What is the mechanism of action of metyldopa

A

Alpha-2 adrenergic AGONIST

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10
Q

What is the mechanism of action of hydralazine

A

Vascular smooth muscle relaxant

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11
Q

Name the sources of progesterone in pregnancy (2)

A
  • Corpus luteum cyst (until 6-7 weeks)
  • Placenta
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12
Q

What are the most common congenital anomalies in patient with T1 or T2 DM

A

Neural tube defect (4.2 fold increase)

Congenital heart disease (3.4 fold increase)

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13
Q

What does BV in pregnancy predispose to?

A

PPROM

PTL

PTB

Post partum endometritis

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14
Q

When are depression symptoms worse in adolescent pregnancy?

A

Between T2 and T3

1/2 have symptoms in early post partum period

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15
Q

What adverse outcomes are adolescent pregnancy linked to?

A

PTB

PPROM

LBW/ IUGR

NICU admissions

Stillbirth

Congenital anomalies

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16
Q

What congenital anomalies are linked to adolescent pregnancies?

A

CNS

(anencephaly, spina bifida, hydrocephaly, microcephaly)

GI

(Gastroschesis, omphalocele)

MSK

(clift lip, cleft palate, polydactyliy, syndactaly)

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17
Q

What is the most common lower genital tract disorder in women of reproductive age?

A

Bacterial vaginosis

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18
Q

What are some risk factors for BV (4?)

A

Black race

Smoking

Sexual activity

Use of vaginal douches

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19
Q

What are the two ways to establish a diagnosis of BV?

A

Amsel criteria

Nugent score (Gram stain, score > 7)

Amsel criteria:

Adherent and homogenous vaginal discharge

Vaginal pH > 4.5

Detection of clue cells

Positive wiff test

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20
Q

What is the treatment + f/u of BV in pregnancy ?

A

Metronidazole (Flagyl) 500 mg PO BID x 7 days

Clinda 300 mg PO daily x 7 days

Repeat culture 1 month after treatment - high recurrence

Topical agents have similar cure rates but

  • Not effective to prevent PTL in high risk population
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21
Q

Name the adverse pregnancy outcomes with BV (5)

A

Spontaneous abortion

PTL and PTB

PPROM

Chorioamionitis

PP infections (Endometritis + CS wound infection)

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22
Q

When should you screen for BV in pregnancy?

A

NO routine screening

Screen if bothersome and persistent discharge

Screen at 12-16 weeks in high risk women

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23
Q

What is oral fluconazole in pregnancy associated to?

A

Tetralogy of Fallot

Safety in 2nd and 3rd trimester not investigated

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24
Q

What is boric acid associated to in pregnancy?

A

2 fold increase in birth defects (during first 4 months)

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25
Q

Define shock index

A

HR / sBP

< 0.7 → normal

> 0.7 → transfuse

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26
Q

Absolute contraindications to neuraxial anesthesia

A

Maternal coagulopathy

Thrombocytopenia

LMWH within 12h

Sepsis

Skin infection at site of needle placement

Refractory maternal hypotension

Increased intracranial pressure caused by mass lesion

3 coags / 2 infection / 2 BP

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27
Q

Describe the following signs:

Goodell

Chadwick

Hegar

A

Goodell : Softening of LUS

Chadwick : Cyanosis / bluish discoloration

Hegar: Softening of cervix

(Hegar = cx dilator)

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28
Q

What test should you order to r/o GDM in patient who underwent gastric bypass surgery?

(# 393)

A

Fasting glucose

1h post prandial blood glucose

HbA1c

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29
Q

Who should you screen before 24-28 weeks for GDM ?

(#393)

A

Maternal age > 35 yo

Pre-pregnancy BMI > 30

PCOS

Acanthosis nigricans

Corticosteroid use

Ethnicity (Aboriginal, African, Asian, Hispanic, South Asian)

Family Hx of DM

Previous pregnancy with GDM

Previous macrosomic infant

30
Q

What are the benefits of optimal glucose control (5)?

(#393)

A

↓ PET

↓ Fetal macrosomia

↓ Shoulder dystocia

↓ CS

↓ IUFD

31
Q

What is the advantage of immediate breat feeding in diabetic mothers (1)?

(#393)

A

↓ neonatal hypoglycemia

32
Q

In GDM mothers, BF x 6 months has what advantages (2)?

(#393)

A

Reduce childhood obesity

Reduce maternal hyperglycemia

33
Q

What proportion of GDM mothers have DM at PP visit?

(#393)

A

1/3

34
Q

What proportion of GDM mothers will have DM later in life?

(#393)

A

15-50 %

35
Q

Describe the different levels of foreceps application (4)

(#381)

A

Outlet : Head visible at introitus without spreading the labias

Low: station > +2 **

Mid: Station between 0 and +2 **

High: Station above 0 (head not engaged)

** 2 subdivisions

  • Rotation < 45 ° from OA position
  • Rotation > 45 ° from OA position (including OP)
36
Q

When should you induce GDM patients ?

(#393)

A

Diet controlled: before 40 weeks

Insulin dependant: 39 weeks

37
Q

How and when do you test for post partum DM?

(#393)

A

2h 75g OGTT

Between 6 weeks and 6 mo post partum

When planning another pregnancy

38
Q

When and how to test for GDM in patients who received betamethasone?

(#393)

A

> 7 days post last dose of beta

2h 75 OGTT

39
Q

Describe antenatal testing for GDM

(#393)

A

US q 3-4 weeks starting at 28 weeks

  • EFW
  • Amniotic fluid volume

Weekly testing at 36 weeks

  • NST
  • NST + AFI
  • BPP
40
Q
A
41
Q

What dermatomes need to be blocked for vaginal delivery and CS?

A

Vaginal delivery: T10 - S5

CS: T4 - S1

(Williams OB p 513)

42
Q

What complication of DM1 in pregnancy leads to the highest number of PTB?

(Williams OB p 1131)

A

Pre-ecclampsia

43
Q

How do you follow a DM1 pregnancy ?

(Berghella)

A

Pre-conception

  • Normalization of HbA1c < 7 %
  • Eye exam
  • 24h urine protein
  • EKG

Antenatal

  • Viability scan
  • Early anatomy scan (14 -16 wks) if HbA1c > 8%
  • AFP screening 16-20 wks
  • Anatomy scan (18-20 wks)
  • Fetal echocardiography (20-22 weeks)
  • Serial growth US
  • 28 weeks: onset of antenatal testing if glucose poorly controlled
  • 32 - 36 weeks: NST and BPP weekly or twice weekly
  • 36 weeks to delivery : Twice weekly

Delivery:

  • 39 weeks
  • If CS, administer evening dose of long acting and hold morning short acting dose

Post partum

  • Decrease insulin dose by half and administer with onset of PO intake
44
Q

What are the neonatal effects of DM1 (5)?

(Berghella + Williams)

A

Hypoglycemia

Hypocalcemia

Hyperbilirubinemia + polycythemia

Cardiomyopathy

Mortality

45
Q

What is the impact of pregnancy on typical DM1 complications (7)?

(Berghella + Williams)

A

Pre-ecclampsia

Retinopathy → can significantly worsen

Nephropathy → if severe, can lead to end stage disease

Neuropathy → no effect, only if gastroparesis (high risk of complication + poor perinatal outcome)

Cardiovascular disease → no change in pregnancy

Ketacidosis → ↑ risk

Infection → ↑ risk of all infections

46
Q

What is a contraindication of pregnancy in pts with DM1?

(Berghella)

A

Symptomatic cardiovascular disease

47
Q

How do you prevent progression of retinopathy in DM1 patients?

A

Good glycemic control

Photocoagulation

48
Q

When does the fetal thyroid start functioning ?

What are thryroid hormone sources before and after that time?

A

10 - 12 weeks

  • Starts concentrating iodine
  • Start formning TSH
  • Small amount of thyroid hormones

18-20 weeks

  • Increased fetal secretion

Before 10-12 weeks → amternal T4 = only source

49
Q

Which Thyroid hormones cross the placenta?

A

T3

T4

TRH (small amount)

TSH receptor Antibody

Does not cross: TSH

50
Q

Describe the different periods of the development of a fetus and corresponding dates

(W OB p 128)

A

Weeks 1-2 : implantation

Weeks 3-8: Embryonic period = organogenesis

Weeks 9-38: fetal period = growth

51
Q

Inheritance pattern of G6PD disorder ?

What medication/ substance should be avoided ?

A

X-linked (recessive)

Methylene blue / Nitrofurantoin

+ long list but none are used in gyne

52
Q

Which stage of labour is affected by obesity?

A

First stage

53
Q

What maternal infections are associated with stillbirth?

(#394)

A

CMV

Parvo B19

Listeria

54
Q

What is the timeline of PP psychosis?

A

Within 2 weeks of birth

55
Q

What is often the first signe of PP psychosis?

(UpToDate)

A

Severe insomnia (more than to take care of infant)

56
Q

What is the most common cause of maternal death during the first year PP?

A

Suicide

(UpToDate: post partum psychosis)

57
Q

What is the risk of infanticide with PP psychosis?

(UpToDate: PP Psychosis)

A

4 %

58
Q

What medical condition is increased in PP psychosis?

(UpToDate PP Psychosis)

A

Autoimmune thyroid disease

Primary Hypoparathyroidism

59
Q

What are the RF for GDM ?

(Berghella p 60)

A

Hx of GDM

Family Hx of DM

Obesity

Age > 35

Non white etchnicity

Prior macrosomic infant

Chronic steroid use

Glycosuria

Know impaired glucose metabolism

Prior infant with congenital anomaly

Prior unexplained stillbirth

60
Q

What is the mechanism of GDM (2)?

Berghella p 61

A

Insulin resistance caused by:

  • ↑ human placental lactogen (maternal and placental production)
  • Progesterone
  • Growth hormone
  • Cortisol
  • Prolactin
  • ↑ BMI and caloric intake

↓ function of pancreatic islet cells

61
Q

What is the % of RhD - in the caucasian population?

A

15 %

In Basque : 30 %

In Asians : 1%

62
Q

If and RhD - patient does not get Rhogham, what is her chance of immunization?

(Berghella)

A

17 %

63
Q

What is the most common reason for izoimmunization ?

(Berghella)

A

Fetomaternal hemorrhage at delivery (>90%)

Third trimester (10%)

64
Q

Other than pregnancy, what are other causes of RBC alloimmunization?

Berghella

A

Amnio 7- 15 %

CVS: 14 %

Induced abortions : 4-5 %

ECV: 2-6 %

First trimester loss (1-2%)

65
Q

How long is Rogham effective for?

Berghella

A

12 weeks

Half life = 16- 24 days

66
Q

What is the incidence of Kell alloimmunization?

(Berghella)

A

0.1 - 0.3 %

67
Q

What is the risk of fetal demise with fetal blood transfusion?

(Berghella)

A

1-2 %

68
Q

What is the risk of error following fetal sex determination by US ?

(#192)

A

3 %

69
Q

Describe warfarin embryopathy ?

When administered in which trimester does it have the worse impact?

What are the other impacts of warfarin on pregnancy?

(#308)

A

Nasal and limb hypoplasia

Stippled bone epiphyses (pattern of focal bone calcification)

Worse in First Trimester (between 6-7 wks)

Effect is dose dependant

Pregnancy loss

Antigoagulation at time of delivery

70
Q

How do you manage an ovarian mass in pregnancy?

A
  • < 5 cm → no surveillance needed
  • 5- 10 cm, US surveillance.
    • Remove if grows, maliganant features, symptomatic
    • Surgery between 14 - 20 wks (most benign cyst will have resolved by then)
  • > 10 cm → Remove (↑ risk of malignancy)
  • NO EVIDENCE for tumor markers except Ca125
    • If 15 wks → delivery, Ca125 between 1000 and 10 000 → ABNORMAL
71
Q

What nerve roots and muscles are affected with Erb’s palsy ?

A

C5 - C6

Paralysis of deltoid, infraspinatus, flexor muscles of forearm

Arm is straight (elbow extended), internally rotated, wrist is flexed (fingers flexed or spared)