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Question 1

what hormones does the placenta produce and what are their actions

Answer 1

Human Chorionic Gonadotropin (hCG): The first placental hormone produced is hCG, which can be found in maternal blood and urine as early as the first missed menstrual period (shortly after implantation has occurred) through the 100th day of pregnancy. This is the hormone analyzed by pregnancy test; a false-negative result from a pregnancy test may be obtained before or after this period. Women’s blood serum will be completely negative for hCG by one to two weeks after birth. hCG testing is proof that all placental tissue is delivered. hCG is present only during pregnancy because it is secreted by the placenta.[12]
hCG also ensures that the corpus luteum continues to secrete progesterone and estrogen. Progesterone is very important during pregnancy because, when its secretion decreases, the endometrial lining will slough off and pregnancy will be lost. hCG suppresses the maternal immunologic response so that placenta is not rejected.
Human Placental Lactogen (hPL [Human Chorionic Somatomammotropin]): This hormone is lactogenic and growth-promoting properties. It promotes mammary gland growth in preparation for lactation in the mother. It also regulates maternal glucose, protein, and fat levels so that this is always available to the fetus.
Estrogen: referred to as the “hormone of women” because it stimulates the development of secondary female sex characteristics. It contributes to the woman’s mammary gland development in preparation for lactation and stimulates uterine growth to accommodate growing fetus.
Progesterone: necessary to maintain endometrial lining of the uterus during pregnancy. This hormone prevents preterm labor by reducing myometrial contraction. Levels of progesterone are high during pregnancy

Question 2

what drugs might be given to prevent pre-term labour,

Answer 2

NO, progesterone, Ca channel blockers, Cox2 inhibitors, but no proven benefits for neonate outcome

Question 3

what are oestrogen and progesterone’s functions in pregnancy,

Answer 3

oestrogen, stimulate uterine growth, promote ductal development in breasts, progesterone, decidulisation of endometrium, uterine quiescence, relaxant on musculoskeletal, alveolar development

Question 4

what changes occur in 3rd trimester to prepare for labour

Answer 4

increased oxytocin receptors on myometrium, increased prostaglandin synthesis, intracellular gap junctions to aid syncronised contraction and cervical dilation, contraction proteins

Question 5

what proteins will trigger labour

Answer 5

Oxytocin, Prostaglandins PGE2, PGFa, IL-1