ObGyn Clerkship - Mostly OB Flashcards
Daily calcium requirements
1000-15000 mg/day
Daily Vitamin D requirements
400-800 international units/day
DM screening timing
Begin at 45, every 3 years thereafter
Osteoporosis screening timing
BMD scan starting at age 65
BMD T-scores
> (-1): Normal
(-1) - (-2.5): Osteopenia
< (-2.5): Osteoporosis
Thyroid screening timing
TSH levels should be tested every 5 years, starting at age 50
HTN Parameters
Systolic >= 140
Diastolic >= 90
Cholesterol screening timing
Every 5 years, starting at age 45
Overweight BMI
25-29.9
Obese BMI
> 30
Beginning and end of the follicular phase
Begins with onset of menses, ends on the day of the LH surge
When does ovulation occur, in respect to the LH surge?
Within 30-36 hours of the LH surge
Beginning and end of the luteal phase
Begins on the day of the LH surge, and ends with the onset of menses
Which phase, luteal or follicular, remains constant, and which can vary?
- Luteal remains constant
- Follicular can vary
MCC of vulvovaginitis
Bacterial vaginsosis
Normal vaginal pH
3.5 to 4.7
The diagnosis of BV is defined by any three of what four criteria?
1) Abnormal gray discharge
2) pH greater than 4.5
3) Positive “whiff test”
4) Presence of clue cells
Bacterial vaginosis treatment
- Oral/topical metronidazole
- Oral/topical clindamycin
With what is a “strawberry cervix” associated?
Trichomonas vulvovaginitis
Trichomonas treatment
Oral metronidazole
MCC of preventable infertility
STDs
Most frequently reported infectious disease in the US
Chlamydia
Greatest risk factor for PID
Prior PID
Which HPV subtypes are usually associated with genital condyloma?
6 and 11
Which HPV subtypes are usually associated with cervical dysplasia/cancer?
16, 18, 31, 33, 45
Most common are 16 and 18
Causative organism of syphilis
Treponema pallidum
What is primary syphilis characterized by?
Painless chancre
What is secondary syphilis characterized by?
Skin rash that often appears as rough, red or brown lesions on the palms of the hands and soles of the feet
What is the conceptus called from the time of fertilization until the pregnancy is 8 weeks old?
Embryo
What is the conceptus called after 8 weeks of pregnancy?
Fetus
What is an infant called when it is born before 24 weeks gestation?
Previable
When should Rh (-) pregnant patients receive RhoGAM?
28 weeks
MCC of first-trimester abortions
Fetal chromosomal abnormalities
Is amniotic fluid acidic or alkaline?
Alkaline
Tests that can be used to diagnose rupture of membranes
- Pool test
- Nitrazine test
- Fern test
When amniotic fluid is placed on nitrazine paper, what color will the paper turn?
Blue (amniotic fluid is alkaline)
5 components of the cervical examination (in a pregnant patient)
- Dilation
- Effacement
- Fetal station
- Cervical position
- Consistency of the cervix
Bishop score
Score made up from the five aspects of the cervical examination (dilation, effacement, fetal station, cervical position, cervical consistency)
A Bishop score consistent with a cervix favorable for labor
> 8
Measurement that determines how thick/thin the cervix is
Effacement
The relation of the fetal head to the ischial spines of the female pelvis
Fetal station
Fetal station
The relation of the fetal head to the ischial spines of the female pelvis
How does the cervical position change during early labor?
Changes from posterior to mid to anterior
Fetal presentation with the head down
Vertex
Fetal presentation with the buttocks down
Breech
Fetal presentation with neither the head nor the buttocks down
Transverse
Describe the location and shape of the anterior fontanelle
- Between the two frontal bones and the two parietal bones
- Larger and diamond-shaped
Describe the location and shape of the posterior fontanelle
- Between the two parietal bones and the occipital bone
- Smaller and more trianglular-shaped
Definition of ‘labor’
Contractions that cause cervical change in either effacement or dilation
Methods by which we can induce labor
- Prostaglandins
- Oxytocic agents (Pitocin)
- Mechanical dilation of the cervix
- Artificial rupture of the membranes
Methods by which we can ripen/dilate the cervix
- Prostaglandin E2 (PGE2) gel
- Prostaglandin E2 pessary (Cervidil)
- Prostaglandin E1 M (Misoprostol)
- Mechanical dilation
How is Pitocin administered? Why?
Continuously via IV because it is rapidly metabolized
Tool used to directly measure the absolute change in pressure during a contraction, thus estimating the strength of the contraction
Intrauterine Pressure Catheter (IUPC)
Normal range for fetal heart rate
110-160
Timing of early decelerations in relation to uterine contractions
Begin and end at approximately the same time as contractions
Cause of early decelerations
Increased vagal tone secondary to head compression during a contraction
Timing of variable decelerations
- Can occur at any time and tend to drop more precipitously than either early or late decels
- Timing is unrelated to contractions
Cause of variable decelerations
- Result from umbilical cord compression
- Repetitive decels can result from entrapment of the cord under the arm or around the neck
Timing of late decelerations
Begin at the peak of a contraction and slowly return to baseline after the contraction has finished
Cause of late decelerations
- Uteroplacental insufficiency
- These are the most worrisome
Baseline intrauterine pressure
10-15 mmHg
Cardinal movements of labor
- Engagement
- Descent
- Flexion
- Internal rotation
- Extension
- External rotation
First stage of labor timing
Begins with onset of labor, lasts until dilation and effacement are complete
Second stage of labor timing
Begins with full dilation and ends with delivery
Third stage of labor timing
Begins after delivery of the infant, ends with delivery of the placenta
MC tumor found on the vulva
Epidermal inclusion cyst
Cervical retention cysts caused by blockage of an endocervical gland
Nabothian cysts
Chadwick sign
Bluish discoloration of the cervix as seen in pregnancy
Bluish discoloration of the cervix as seen in pregnancy
Chadwick sign
Softening of the cervix, as seen in pregnancy
Hegar sign
Hegar sign
Softening of the cervix, as seen in pregnancy
Reactive/reassuring nonstress test
At least 2 fetal heart accelerations of at least 15 mins above the baseline HR in 20 minutes
How long does it take to determine that a nonstress test is “nonreactive”/”nonreassuring”?
40 minutes
What is a neoplasm of the uterine muscular wall called?
Sarcoma
What is a neoplasm of the endometrial lining called?
Adenocarcinoma
Which type of ovarian cyst is associated with ovulation?
Follicular cyst
Which type of ovarian cyst is associated with pregnancy?
Corpus luteum cyst
Which type of cyst is often bilateral, resulting from excess hCG secretion in molar and multigestation pregnancy?
Thecal cyst
Which lab value is helpful in the assessment of a patient for ovarian cancer?
CA-125
What “surgical” procedure can be done to help an incompetent cervix?
Cerclage
With what pathology is a strawberry cervix associated?
Trichomonas cervicitis
Definition of primary amenorrhea
- No menses by 14 with normal sexual development, OR
- No menses by 13 without normal sexual development
Definition of secondary amenorrhea
Cessation of menses for 6 months not associated with menopause
Most common cause of secondary amenorrhea
Pregnancy
Definition of dysmenorrhea
8-72 hours of pelvic pain with menstruation
Average age of menopause
51.5 years
Premature menopause (definition)
When menses stop before age 40
Lab used in the diagnosis of menopause
FSH
What FSH levels are diagnostic of menopause
> 30 mlU/mL
Instances in which you cannot use HRT
- Unexplained vaginal bleeding
- History of DVT/PE
- History of GYN tumors that may be estrogen-sensitive
Medical terms for breast pain
Mastalgia or mastodynia
MC organism responsible for mastitis
Staph aureus
MC benign condition of the breast
Fibrocystic changes
What breast pathology is associated with the following changes:
- Round
- Firm
- Smooth
- Mobile
- Non-tender
Fibroadenoma
Which breast pathology is associated with the following changes:
- Painful
- Fluctuating size
- Multiple masses
Fibrocystic changes
Most common type of breast cancer
Ductal carcinoma (80%)
Two types of breast cancer
Ductal carcinoma
Lobular carcinoma
Paget’s disease of the breast (definition)
Ductal carcinoma of the nipple
Skin changes associated with Paget’s disease
-Scaly, eczematous, erythematous nipple lesion
Spontaneous flow of milk from the breast (term)
Galactorrhea
Why could a pituitary adenoma cause galactorrhea?
It could cause hyperprolactinemia, which would cause the galactorrhea
Definition of infertility
Failure to conceive after 1 year of unprotected intercourse
What medication can be given to anovulatory women to stimulate ovulation?
Clomiphene citrate (Clomid)
How does clomiphene citrate (Clomid) work?
By inhibiting estrogen receptors in the hypothalamus, removing the (-) feedback on gonadotropin release
Cervical motion tenderness (what is this sign called?)
Chandelier’s sign
What tool can be used for monitoring the fetus internally?
Fetal scalp electrode
Most accurate method of monitoring the fetus during labor
Fetal scalp electrode
What are some simple measures that can be taken if concerned about fetal heart rate during labor?
- Lay mom on left side
- Give mom oxygen
- Stop pitocin
Five categories of the APGAR score
- Appearance (color)
- Pulse
- Grimace (reflex to nasal suctioning)
- Activity (motor tone)
- Respiration
Causes of early postpartum hemorrhage
- Laceration
- Retained products of conception
- Abnormal uterine involution
Causes of late postpartum hemorrhage
- Retained products of conception
- Endometritis
What drugs can be given to treat postpartum hemorrhage?
- Prostaglandins
- Oxytocin
- Ergonovine (Ergometrine)
- All used to enhance uterine contraction
How long does it take the uterus to descend back into the pelvis?
2 weeks
How long does it take for the uterus to involute to normal size?
6 weeks
Medical term for the sloughing of decidual tissues in the postpartum period
Lochia
Most common location of ectopic pregnancy
Ampulla of the fallopian tube
Patient presents with RLQ pain and vaginal bleeding. On exam, you feel an adnexal mass. What do you suspect?
Ectopic pregnancy
What drug can be given to a patient with an ectopic pregnancy?
Methotrexate
If premature labor is a possibility, what drug can you give to the mother to increase fetal lung maturity?
Betamethasone (Celestone)
Triad of preeclampsia (mild)
- HTN >140/90
- Edema
- Proteinuria >300mg in 24-hour urine
Blood pressure requirements for a diagnosis of severe preeclampsia
SBP >160 mmHg, OR
DBP >110 mmHg
*On at least 2 occasions at least 6 hours apart with bed rest in between
Proteinuria requirements for a diagnosis of severe preeclampsia
> 5g in a 24-hour urine
HELLP Syndrome
Severe preeclampsia, plus:
- Hemolysis
- Elevated Liver enzymes
- Low platelets
If a patient has preeclampsia with one pregnancy, what is the risk of her developing preeclampsia with subsequent pregnancies?
25-33% risk
What drug do we give patients with preeclampsia for seizure prophylaxis and at what dose?
- Magnesium sulfate
- 4g load and 2g/hour maintenance
In the case of magnesium sulfate overdose, what should be given for cardiac protection?
10mL of 10% calcium chloride or calcium gluconate
When is RhoGam given to Rh (-) moms?
- 28-29 weeks
- If baby is Rh (+) at birth, give another dose to Mom at birth
Most common cause of 3rd trimester bleeding
Abruptio placentae
Classic presentation of abruptio placentae
Painful vaginal bleeding
Classic presentation of placenta previa
Painless 3rd trimester vaginal bleeding
Painful vaginal bleeding is the classic presentation for what? (During pregnancy)
Placental abruption
Painless vaginal bleeding is the classic presentation for what? (During pregnancy)
Placenta previa
Complete abortion (definition)
Complete expulsion of all POC before 20 weeks’ gestation
Complete expulsion of all POC before 20 weeks’ gestation
Complete abortion
Incomplete abortion (definition)
Partial expulsion of some, but not all POC before 20 weeks’ gestation
Partial expulsion of some, but not all POC before 20 weeks’ gestation
Incomplete abortion
Inevitable abortion (definition)
No expulsion of products, but bleeding and dilation of the cervix such that a viable pregnancy is unlikely
No expulsion of products, but bleeding and dilation of the cervix such that a viable pregnancy is unlikely
Inevitable abortion
Threatened abortion (definition)
Any intrauterine bleeding before 20 weeks’ gestation without dilation of the cervix or expulsion of any POC (no loss of fluid or tissue)
Any intrauterine bleeding before 20 weeks’ gestation without dilation of the cervix or expulsion of any POC (no loss of fluid or tissue)
Threatened abortion
Missed abortion (definition)
- Death of the embryo/fetus before 20 weeks’ gestation, with complete retention of POC
- Often proceed to complete abortion within 1-3 weeks, but are occasionally retained much longer
- Death of the embryo/fetus before 20 weeks’ gestation, with complete retention of POC
- Often proceed to complete abortion within 1-3 weeks, but are occasionally retained much longer
Missed abortion
Precipitous labor
Labor lasting < 3hours
Precipitous delivery
Delivery to a non-sterile field
Why do pregnant patients often require iron supplementation?
Because RBC volume increases by 35%
Effects of progesterone on the GI system during pregnancy
Progesterone cause smooth muscle relaxation, resulting in:
- Decreased esophageal sphincter tone –> Reflux
- Decreased motility –> Constipation
- Decreased gallbladder contraction –> Increased risk of gallstones
Term used for thick, white vaginal discharge
Leukorrhea
What causes blurred vision in pregnancy?
Increased thickness of the cornea due to fluid retention
What type of antibodies can cross the placenta?
IgG anitbodies
Term used to describe the settling of the fetal head into the pelvis before the onset of labor
Lightening
What are Leopold’s maneuvers used to determine?
- Lie (transverse or vertex)
- Presentation (breech or cephalic)
- Position (facing left or right)
Term for failure of the uterus to contract after delivery
Uterine atony
What drugs can be given in the case of uterine atony?
- Oxytocin
- Methergine
- Prostaglandins
Fourth stage of labor timing
Begins after delivery of the placenta, and ends 2 hours later
Difficult labor or childbirth (term)
Dystocia
What is it called when the fetal lie is with the head turned to one side?
Asynclitism
What is it called when the fetal lie is with one or more limbs prolapsed alongside the presenting part?
Compound presentation
At what point is the latent phase of labor considered abnormally prolonged?
> 20 hours in nulliparous patient
> 14 hours in multiparous patient
Definition of arrested labor
- No fetal descent after 1 hour of pushing in a patient with anesthesia
- Descent < 1cm/hour in a patient with no anesthesia
Absence of a major portion of the brain, skull, and scalp that occurs during embryonic development
Anencephaly
Breech presentation in which the legs are brought up so the feet are near the head
Frank breech
Breech presentation in which the legs are crossed beside the bottom (baby is sitting cross-legged)
Complete breech
Breech presentation in which one of the legs is extended below the bottom
Footling (incomplete) breech
Attempt to rotate the fetus in a breech position to a vertex/cephalic position
External cephalic version (ECV)
External cephalic version (ECV)
Attempt to rotate the fetus in a breech position to a vertex/cephalic position
Turtle sign
- Associated with shoulder dystocia
- Head retracts between contractions/pushing
- Signs associated with shoulder dystocia
- Head retracts between contractions/pushing
Turtle sign
Positioning/maneuver involving hyperflexing the mother’s legs up near her chest in an effort to widen the pelvis and flatten the lumbar spine
McRobert’s position/maneuver
Bradycardic fetal heart rate
< 120 bpm
MCC of fetal tachycardia
Chorioamnionitis
Tachycardic fetal heart rate
> 160 bpm
Minimal fetal heart rate variability
< 5 bpm deviation from baseline
Moderate fetal heart rate variability
Between 6 and 25 bpm deviation from baseline
Marked fetal heart rate variability
> 25 bpm deviation from baseline
White substance covering the baby when he’s born to protect him from being in the amniotic fluid for so long
Vernix
What antibiotic ointment is applied to the eyes of a newborn if the mother has gonorrhea?
Erythromycin or Tetracycline
Normal size of a nonpregnant uterus
60-80 grams
Individual sections of the placenta that implant in the uterus
Cotyledons
Placental invasion of the superficial lining of the uterus
Placenta accreta
Placental invasion into the myometrium
Placenta increta
Placenta increta
Placental invasion into the myometrium
Placenta accreta
Placental invasion of the superficial lining of the uterus
Placenta percreta
Placental invasion through the full thickness of the uterine muscle
Placental invasion through the full thickness of the uterine muscle
Placenta percreta
What meds can be given to cause uterine relaxation?
Terbutaline, Magnesium sulfate
Substance secreted by the breasts in the early postpartum period that contains more minerals and proteins, but less sugar and fat than mature milk
Colostrum
How long does colostrum secretion persist?
About 5 days
What should happen to hCG levels with a spontaneous abortion?
They should drop by 15% by the next day
When should a transvaginal and abdominal ultrasound be able to visualize the pregnancy? (hCG levels, not time)
hCG of 1000-2000 with transvaginal
hCG of 5000-6000 with abdominal
What effect on hCG levels should you see with administration of methotrexate for an ectopic pregnancy?
15% decline between days 4 and 7
Ectopic pregnancy candidates for methotrexate therapy
hCG < 5000
Ectopic size < 3.5cm
No cardiac activity
Ectopic pregnancy implanted in the proximal tube (what is it called?)
Cornual ectopic
Placenta previa in which the entire cervical os is covered by the placenta
Total placenta previa
Placenta previa in which the placenta covers a portion of the internal os
Partial previa
Placenta previa in which the edge of the placenta reaches the margin of the internal os
Marginal previa
Types of placental abruption
Complete, Partial, Marginal
MCC of coagulopathy in pregnancy
Placental abruption (clotting factors run low because they’re all being used up in the uterus)
What is it called when fetal blood vessels are present over the internal os, below the fetus?
Vasa previa
Why does HCT normally decrease in pregnant patients?
Because plasma volume expands proportionally greater than that of RBC mass
What placental hormone increases insulin resistance?
Human placental lactogen (hPL)
What should the 1-hour 50gm glucose challenge test glucose levels be?
< 140 mg/dL
When is the glucose challenge test performed?
Between 24 and 28 weeks
What should the fasting, 1hour, 2hour, and 3hour glucose levels be in a 3-hour glucose tolerance test?
Fasting: < 105
1-hour: < 190
2-hour: < 165
3-hour: < 145
For gestational diabetic patients monitoring their glucose at fasting and 2 hours after meals, what should the values be?
Fasting: < 95
2-hour Postprandial: < 120
Chronic hypertension (definition as it relates to pregnancy)
HTN present before the 20th week of pregnancy
Gestation hypertension definition
HTN that develops after 20 weeks’ gestation in the absence of proteinuria and returns to normal in the postpartum period
1st line tx for pregnant patients with asthma
Inhaled corticosteroid Budesonide
Most significatn cause of morbidity with multifetal gestation
Preterm labor and delivery
Describe the chorionicity when zygote divides within 3 days of conception
Diamnionic/dichorionic with either one or two placentas
Describe the chorionicity when zygote divides between 4-8 days of conception
Diamnionic/monochorionic
Describe the chorionicity when zygote divides between 9-12 days of conception
Monoamnionic/monochorionic
What happens if a zygote divides after day 13?
Conjoined twins
What chorionicity allows for twin-twin transfusion syndrome?
Monochorionic pregnancies
What pathognomic ultrasound findings are associated with gestational trophoblastic neoplasia?
“Snowstorm” and absence of fetal parts or partially developed fetal parts