OBGyn Flashcards

1
Q
Abruptio placentae
Path:
Pt:
Dx:
Tx:
Complications:
A

Path: Separation of placenta from its site of implantation before delivery of the fetus
-Visible if blood between membranes and uterus -escapes through cervix
Concealed if blood is retained between detached placenta and uterus
-MC associated w/ Maternal htn (essential, gestational, preeclampsia)

Pt:
Vaginal bleeding
Uterine tenderness or back pain
Fetal distress
Preterm labor
High-frequency contractions
Hypertonus (inc resting tone)
Dead fetus 

Dx: Clx

Tx:
Maternal resuscitation w/ blood and crystalloid
Delivery
For viable fetus: cesarean section if vaginal delivery is not imminent
For abruption demise: start induction when mother is stabilized

Complications:
Consumptive coagulopathy -> DIC
Renal failure 
Fetal demise
Couvelaire uterus: widespread extravasation of blood into the uterine musculature beneath uterine serosa
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2
Q

Breech presentation
Path:
Dx:
Tx:

A

Path:
Lie: long axis of fetus (longitudinal, transverse, oblique)
Presentation: fetal part that directly overlies pelvic inlet: vertex (head), breech
Dx:
Head is not palpated above symphysis pubis
U/S to confirm fetal position: Also assesses for maternal pelvic abnormalities, uterine abnormalities and placenta previa

Tx:
External version can be attempted at 37w
Active labor: C/S

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3
Q
Umbilical cord prolapse 
Path:
Pt:
Dx:
Tx:
A

Path: Risk factors: Unstable lie, Footling breech, Polyhydramnios, Prematurity, FGR (Fetal growth restriction), Multiparity, Long umbilical cord, Multifetal gestation, Unengaged presenting part

Pt: Hx of malpresentation, PROM

Dx: Cord precedes presenting part increasing cord pressure leading to fetal anoxia

Tx:
Lift baby’s head and try to decompress (usually more cord comes out)
Emergent C/S
Tocolytic: terbutaline 0.25mg sub-q to decrease uterine contractions and alleviate pressure on the cord
If delay in c/s-> Trendelenburg position, knee-chest position, bladder filling, elevation of present fetal part

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4
Q

Dystocia
Path:
Dx:
Tx:

A

Path: Failure of the shoulders to spontaneously traverse the pelvis after delivery of the fetal head, requiring extra maneuvers to enable delivery of the fetal shoulders

Dx: Central traction on fetal head does not produce delivery of the shoulders

Tx:
McRoberts’ maneuver followed by suprapubic pressure to release impacted shoulder
-Flex one of mother’s legs until her thighs touch her abdomen thus fattening the sacrum and rotating the symphysis pubis cephalic ally
-Delivery of posterior fetal arm

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5
Q
Ectopic pregnancy
Path:
Pt:
Dx:
Tx:
A

Path: Zygote implants not in uterus
MC ampulla
Stricture
Risk factors: Hx of PID, Tubal ligation, Prior ectopic, IUD, Assisted reproductive techniques, In vitro fertilization

Pt:
Abdominal pain, Bleeding
UPT +

Dx: 
B-Quant
>/=1500 w/ negative TV U/S
<1500
-Too soon to tell
-If B-HCG doubles in 48 hours-> normal pregnancy 
Tx:
Salpingostomy: no rupture 
Salpingectomy: + rupture 
Methotrexate (+/- leucovorin) ok if:
-B-HCG <5000
-Gestation sac <3.5cm
-No heart tones
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6
Q

Fetal distress

dx:

A

Fetal heart rate monitoring

  • Absent variability with recurrent late decelerations
  • Absent variability with recurrent variable decelerations
  • Absurd variability with bradycardia or a sinusoidal pattern
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7
Q

Gestational diabetes
Dx:
Tx:
Complications:

A
Dx: 
Fasting >95
Screening between 24 and 28w w/ 
50g glucose load
>130-140 after 1hr
100g glucose challenge with
>180 at 1hr
>155 at 2hr
>140 at 3hr

Tx:
Medical nutritional therapy -> diet and exercise routine
Insulin
Oral glyburide, metformin-> only if pt unwilling/unable to use insulin therapy to control glucose levels

Complications:
Fetal risks-> macrosomia, respiratory distress syndrome, neonatal hypoglycemia
Maternal risk-> inc DM-II

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8
Q

Gestational trophoblastic disease
Pt:
Dx:
Tx:

A

Molar pregnancy
Pt: N/V, abd pain, vaginal bleeding
New onset HTN <20w, suspect molar pregnancy
PE: uterine size larger than expected for dates

Labs: B-hCG higher than expected for dates
Dx: U/S: snowstorm/bag of grapes

Tx: D&C

Choriocarcinoma
Risk factors: extremes of maternal age, hx of previous mole, vitamin A deficiency

Pt: Vaginal bleeding, Pelvic discomfort, Hyperemesis gravidarum

Dx:
PE: uterus large than expected for gestational age
B-HCG usually high
Higher for complete moles than partial moles
TV-U/S: absence of an embryo or fetus and central heterogeneous mass w/ numerous discrete anechoic spaces -> “snowstorm” or “bag of grapes” appearance

Tx:
Uterine evacuation with suction curettage
Weekly hCG until undetectable
If levels remain elevated or rise-> gestational trophoblastic neoplasia tx with hysterectomy

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9
Q
Pregnancy induced hypertension 
Path:
Pt:
Dx:
Tx:
A

Path: HTN no proteinuria after 20w gestation
Resolves 12w postpartum
Thought to be due to arteriolar vasoconstriction

Pt: Asx

Dx:
BP >/=140 / >/=90
No proteinuria

Tx:
May withhold meds
+/- hydralazine, labetalol
Monitor for preeclampsia

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10
Q
Preeclampsia 
Path:
Pt:
Dx:
Tx:
A

Path:HTN + proteinuria +/- edema AFTER 20w gestation (earlier in multiple gestation or molar pregnancy)

Without severe features 
Pt: Asx
Dx: 
BP >/=140 / >/=90 sustained, starting after 20w
Urine: 300mg/dL proteinuria (1+ dip stick)
Tx:
>37w deliver urgently (induce)
<37w bed rest 
With severe features
Pt:
Sx of HTN: HA, visual sx 
Fetal growth restriction
Edema caused by proteinuria (dec oncotic pressure) 

Dx:
BP >160 / >110 sustained, starting after 20w
Proteinuria 5g/24h (3+ dip stick)
Oliguria (<500ml/24h)
Thrombocytopenia, +/- DIC
HELLP syndrome: (Hemolytic anemia, Elevated liver enzymes, Low Platelets)

Tx:
Prompt delivery
Magnesium sulfate (seizure prevention)
BP meds in acute severe HTN: Hydralazine, Labetalol, Nifedipine

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11
Q
Eclampsia 
Path:
Pt:
Dx:
Tx:
A

Path: Seizures or coma in pts who meet preeclampsia criteria

Pt:
Abrupt tonic-clonic seizures
HA, visual changes, cardiorespiratory arrest

Dx:
Same at preeclampsia + seizures
Hyperreflexia

Tx:
ABCD’s 1st
Magnesium sulfate for seizures (lorazepam if refractory)
Delivery of fetus once mom is stabilized
BP meds: hydralazine, labetalol
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12
Q
Incompetent cervix
Path:
Pt:
Dx:
Tx:
A

Path: Inability to maintain pregnancy 2/2 premature cervical dilation (esp in 2nd trimester)

Risk factors: Previous cervical trauma or procedure (tx for CIN), Uterus defects, DES exposure in utero, Multiple gestations

Pt: bleeding, vaginal discharge especially in 2nd trimester

Dx: painless dilation and effacement of cervix

Tx:
Cerclage (suturing of cervical os) and bed rest especially if prior hx
If not performed initially, cerclage can also be performed for women who develop a short cervix (=25mm) before 24w as determined by U/S surveillance
+/- weekly injection of 17 alpha-hydroxyprogesterone in some women with preterm birth hx

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13
Q

Multiple gestations

A

Monochorionic: share placenta
At risk for twin-twin transfusion syndrome
Quintero system:
-Stage I: manage expectantly w/ weekly Doppler blood flow studies; poly/oligohydramnios (recipient poly; donor oligo); Visualize bladder in both fetuses; Normal umbilical doppler flow
-Stage II: Bladder of donor fetus is not visualized on U/S
-Stage III: abnormal doppler flow to either fetus
-Stage IV: Signs of hydrops
-Stage V: Death of one or both fetuses
16-26w stage II-IV: fetoscopic laser ablation of placental anastomoses
>26w: amnioreduction

Monoamniotic: share amniotic sac
-Highest risk for complications

Diamniotic/Dichorionic: inhabit separate amniotic sacs/own placenta

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14
Q
Placenta previa
Path:
Pt:
Dx:
Tx:
A

Path: placenta is located over/very near internal os

  • Complete previa: covers entire os
  • Incomplete previa: placenta at the edge of/partially covers os
  • Low-lying: placenta is within 2cm of internal os

Risk factors: Prior cesarean delivery, Advanced maternal age, Multiparity, Smoking

Pt: Painless hemorrhage occurring at end of 2nd trimester or later in pregnancy

Dx:
Doppler TV U/S @20w (early in pregnancy may resolve by term from placental migration)
Speculum exam visualize bleeding is from above the os

Tx:
Ideal: term fetus or fetus w/ documented lung maturity can be scheduled for routine cesarean
Less ideal: pt w/ known previa presents in labor and receives emergent cesarean
Least ideal: severe hemorrhage preterm mandating stat cesarean

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15
Q

Postpartum hemorrhage

A

Path: Bleeding from placental implantation site

Atony: Uterus unable to contract to stop bleeding 
Retained placental products 
Trauma to the genital tract
Rupture uterus 
Coagulation defects
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16
Q

Atony
Path:
Pt:
Tx:

A

Path: Uterus unable to contract to stop bleeding

Risk factors: (additive)

  • Over-distended uterus: Large fetus, Multiple gestation, Hydramnios
  • Rapid labor
  • Prolonged labor
  • Use of labor augmentation agents: Pitocin
  • Chorioamnionitis
  • Hx of uterine atony

Pt: Postpartum hemorrhage

Tx:
1. First: Vigorous massage: bimanual exam and massage of uterine fundus; Oxytocin infusion; Manual exploration of uterine cavity for retained placental products

  1. Second: Pharmacological agents: Prostaglandins F2alpha (prostin, carboprost), Ergot derivatives (methergine), Prostaglandin E1 (misoprostol, cytotec)
  2. Third: Surgical management: Hypogastric artery ligation, Uterine compression sutures (B-lynch), Uterine packing, Peripartum hysterectomy
17
Q

Retained placental parts
Path:
Pt:

A

Path:

  • Accreta: abnormal Adherence to the uterine wall
  • Increta: Invade the myometrium
  • Percreta: Penetrates the uterine serosa and can invade surrounding organs such as bladder or rectum

Risk factors:

  • Placenta previa: placenta located over/near the cervical os
  • Prior cesarean delivery
  • Prior uterine curettage
  • Grand multiparity: women who has had >/= 5 births at >/=20w

Pt: postpartum hemorrhage

18
Q

Trauma to the genital tract postpartum hemorrhage
Path:
Dx:

A

Path:
Episiotomy
Vaginal or cervical lacerations

Dx:
bleeding despite a well-contracted, firm uterus, hemorrhage is likely from a laceration
Bright red blood suggests laceration
Seen on careful inspection of vagina and cervix

19
Q

Ruptured uterus
Path:
Pt:

A

Path:
MC is separation of the previous cesarean hysterotomy scar
Others: trauma, congenital abnormality, prior uterine surgery (myomectomy)

Pt: postpartum hemorrhage

20
Q
Premature rupture of membranes 
Path:
Pt:
Dx:
Tx:
A

Path:
Normal vaginal fluid is acidic (3.5-6)
Amniotic fluid is alkaline

Pt: Rupture of membranes <37w

Dx:

  • Nitrazine paper color change to blue
  • Ferning: distinctive pattern of amniotic fluid as it crystallizes on glass slide
  • Assess cervix for effacement and dilation

Tx:
Admission + OB consultation
Tocolytics-> prolong pregnancy to allow continued time for fetal development
Antenatal administration of corticosteroids if <34w

It’s Not My Time:

  • Indomethacin (not given at 33w due to risk of PDA closure)
  • Nifedipine
  • Magnesium sulfate
  • Terbutaline
21
Q
Rh incompatibility 
Path:
Pt:
Dx:
Tx:
A

Path:
Maternal antibodies that bind to fetal RBCs -> neonate hemolytic disease
Occurs if Rh negative (rhesus factor) mother carries an Rh positive fetus w/ exposure to fetal b mood mixing:
-C/S
-Abruptio placentae
-Placenta previa
-Amniocentesis
-Vaginal delivery
The mixing causes maternal immunization -> maternal anti-Rh IgG antibodies. During subsequent pregnancies, if she carries another Rh + fetus, the antibodies may cross the placenta and attack the fetal RBCs -> hemolysis of fetal RBCs

Pt (newborn):
Hemolytic anemia, jaundice, kernicterus, hepatosplenomegaly
Fetal hydrops: fluid accumulation in 2 spaces: pericardial effusion, ascites, pleural effusion, subcutaneous edema; CHF

Dx: 
Pregnant women: 
-ABO blood group, RH-D type
-Indirect erythrocyte antibody screen: 1:8 - 1:32 associated w/ fetal hemolysis
-Indirect Coombs 

Fetus monitoring in 2nd trimester:

  • If present -> amniotic fluid: inc bilirubin
  • U/S of middle cerebral artery (inc flow 2/2 decreased viscosity of blood in anemia)
  • Percutaneous umbilical blood sampling: decreased hematocrit

Tx:
Prevention in mother: RhoGAM
-MOA: Rh immunoglobulin-pooled anti-D IgG binds to fetal RBCs to prevent maternal mixing
3 indications:
-Given at 28w gestation AND
-72h of delivery OR
-After any potential mixing of blood: SAB, vaginal bleeding, etc.

22
Q
Endometriosis 
Path:
Pt:
Dx:
Tx:
A

Path:
Endometrial glands and stroma which occur outside of the uterine cavity
MC site: ovaries (endometriomas)

Risk factors: nulliparity, prolonged exposure to endogenous estrogen, exposure to diethylstilbestrol in utero, lower BMI

Pt: Reproductive women w/ pelvic pain (dysmenorrhea, dyspareunia) , Infertility, Ovarian mass

Dx:
PE: immobility or lateral displacement of cervix or uterus
Eval w/ TVU/S or MRI
DDx: histologic analysis of lesions

Tx:
Continuous hormonal contraceptive + NSAIDs
Laparoscopic excisions

23
Q

Leiomyoma
Path:
Pt:
Tx:

A

Path: Benign fibromuscular tumors of the myometrium
Proposed etiology: venous congestion within uterus

Types:
Pedunculated 
Intracavitary 
Submucosal 
Intramural 
Subserosal 

Pt: When symptomatic, AUB MC sx

Tx:
Observation
Medical therapy
Myomectomy
Hysterectomy 
Alternatives: uterine artery embolization, high intensity focused U/S
24
Q

Uterine prolapse
Path:
Pt:
Tx:

A

Path:
Uterine herniation into the vagina
Risk factors: (weakness of pelvic support structures)
MC after birth (especially traumatic)
Inc pelvic floor pressure: Multiple vaginal births, Obesity, Repeated heavy lifting

Grades:
I: decent into upper 2/3 of vagina
II: cervix approaches introitus 
III: outside introitus 
IV: entire uterus outside of vagina- complete prolapse 

Pt:
Pelvic or gain fullness, heaviness “falling out” sensation
Lower back pain (esp w/ prolonged standing)
Vaginal bleeding, purulent discharge
Urinary frequency, urgency, stress incontinence

Tx:
Prophylactic: Kegel exercises (strengthens pelvic floor muscles), weight control
Nonsurgical: pessaries (sx relief); Improves atrophy
Surgical:
-Hysterectomy
-Uterosacral or sacrospinous ligament fixation

25
Q
Polycystic Ovarian Syndrome
Path:
Pt:
Dx:
Tx:
A

Path: Inc insulin -> inc LH-driven inc ovarian androgen production

Pt:
Amenorrhea
Obesity
Hirsutism

Dx:
LH:FSH ratio >3:1
Pelvic U/S: “string of pearls”
Ovarian volume >10cm3/mL
>/= 12 antral follicles 
Tx:
OCPs
Spironolactone 
Infertility-> clomiphene 
Lifestyle changes