Obesity, Insulin Resistance II, and Type 1 Diabetes Flashcards
1
Q
Most important environmental risk factor for insulin resistance is
A
obesity
2
Q
Why does insulin resistance occur?
A
- Rarely monogenic problems in insulin transduction
- Usually a combination of factors, involving numerous genes and environmental risk factors
3
Q
what are the satiety signals:
A
- leptin
- GRP1
- CCK
-PYY - Vagal afferents
4
Q
what are the hunger signals:
A
ghrelin
5
Q
Non-esterified fatty acids (NEFA) increase
A
insulin resistance
6
Q
non-esterified fatty acids are released more from ? than ?
A
central fat
peripheral fat
7
Q
what modify sensitivity of insulin receptors?
A
adipokines
8
Q
in type I diabetes, it is an autoimmune destruction of ?
A
beta cells
9
Q
as you kill beta cells - remaining cells become ?
A
hyperproductive
10
Q
what is honeymooning
A
the ability of remaining beta cells to become hyperproductigve
