Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Block 10 Week 2 > Obesity and Satiety Drugs-She Burkin > Flashcards

Obesity and Satiety Drugs-She Burkin Flashcards

1
Q

Over (blank) percent of adults are overweight or obese

A

66%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What are the complications of obesity?

A 
sex hormone imbalance
-Hormone dependent tumors
increased FFAs
-CV disease
physical stress
-SOB
-Low back pain
-osteoarthritis
-sleep apnea
Quality of life-depression
Disease: type 2 DM
fatty liver
gall bladder disease
pancreatitis
gynecologic abnormalities
pulmonary disease
cataractis
stroke
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Orexigenic means?

anorexigenic means?

A

appetite stimulating

appetite suppressing

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

The body modulated hung and satietey by sensing metabolic parameters which are…?

A

blood glucose levels

amounts of stored fat

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

(blank) levels are critical to how hungry you are (short term). Declines are sensd in what organ? What does this organ signal to?

A

blood glucose
liver
the hypothalamus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What regulates long term hunger regulation?

A

amount of stored glycogen or ration of utilizing stored carbohydrate: lipid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Ghrelin, leptin, insulin and PYY all bind receptors on orexigenic or anoreigenic neurons in the ARC of the (blank). What does the hypothalamus do once it senses this?
Signals travel along axons to secondary neurons. The ultimate effect is change in the sensations of hunger or satiety.

A

hypothalamus

Release of eorexigenic neuropeptide or anorexigenic neuropeptides.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

A lot of satiety responses travel along the (blank)

A

vagus nerve

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

T or F

When food is readily available, people eat when there is no physiological reason.

A

T

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Where does fat store?

A

adipocytes and intraperitoneal cavity

can store in liver-fatty liver disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Obesity is associated with increased (blank) of adipocytes

A

size and number!

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Why is BMI stupid?

A

because it doesnt include muscle mass

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Who gets bariatric surgery?

A

BMI > 40, exercise and diet doesn’t work, and obesity-related comorbid conditions

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What is this:

resecting and rerouting the small intestine to a small stomach pouch

A

gastric bypass

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What is this:

removal of a portion of the stomach

A

sleeve gastrectomy with duodenal switch

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Complications of bariatric surgery?

A

40% complication in first 6 months

  • gastric dumping syndrome (1/5 patients): food enters stomach uningested and small intestine expants to quickly and fluid shifts into gut lumen and you get n/v bloating, cramping, diarrhea, dizziness, fatigue
  • infection, incisional hernia, leak at surgical site
  • steopenia and secondary hyperparathyroidism
  • gallstone and imparied kindey function
17
Q

What is the vagus nerve stimulator?

Who can get it?

A

-over 18, BMI 35-40 with comorbid obesity condition
wire leads and electrodes are surgically implanted in the abdommen-> sends intermittent electrical pulses to the vagus nerve -> triggers sense of satiety

18
Q

IS the vagus nerve stimulator effective?

A

TX group lost 8.5% more weight than control group

18 month study indicated weight loss was sustained

19
Q

Who should you give obesity drugs to?

A

if you have BMI>30 w/out risk factors OR

BMI >27 w/ risk factors

20
Q

What are the FDA approved appetite suppressants?

A 
Phentermine monotherapy
Phenteremine plus extended topiramate combo
Lorcaserine (belviq)
Diethylproprion
Phendimetrazine
21
Q

What are the FDA approved nutrient absorption blockers?

A

Orlistat (Xenical)

22
Q

Phentermine contraindications?

A

history of drug abuse
SSRI or MAOI
Dont use with other weight loss drug
Pregnancy or breast feeding

23
Q 
What is this:
level 2 evidence
controlled release phentermine
pus topiramate
effects not specific to hypothalamus
high drop out rate (bad SEs)
SEs paresthesia, dry mouth, constipation, dysgeusia
Pregnancy cat D: risk of cleft palate
A

Phenteremine plus extended topiramate combo (Qsymia)

24
Q 
What is this:
Selective 5-HTc receptor agonist
level 2
works only in hypothalamus
selectovely activates serotonin 2C receptors
-increase satiety
A

Lorcaserin (Belviq)

25
Q

SEs of Lorcaserin?

A 
Serotonin syndrome (changes in autonomic instability, fast onset (min to hours), neuromuscular hyperactivity)
disturbances in attention and memory
26
Q

What should you not take lorcaserin with?

A

SSRIs
MAOIs
Dopamine antagoinist
St john wart

27
Q

When should you stop using lorcaserin?

A

discontinue use if failure to lose 5% weight after 12 weeks

NOTE: safe and effective known for 2 years.

28
Q

What is this:
amphetamin derivative
ass. w/ weight loss in obese women (level 2)
short term use only
monotherapy
orally 3x daily 1 hr before meals or 1x daily

A

diethylpropion (tenuate)

29
Q

What are the common side effects of diethylpropion?

A 
insomnia
dry mouth
pulmonary HTN 
valvular hear disease
CNS effects
withdrawal abuse
30
Q

Contraindications for diethylpropon?

A

drug abuse
pregnancy
MAOIs

31
Q

What is this:
amphetamine derivative
anorexigenic activity, due to CNS stimulation
alpha-1 adrenergic receptor agonist

A

Phendimetrazine

32
Q

What is this:
Alli or Xenical (generic names)
inhibitor of gastric and pancreatic lipases
reduces TAG hydrolysis and fat absorption
Moderately effective at losing weight
ONLY FDA approved treatment for LONG TERM tx of Obesity

A

orlistat

33
Q

Contraindications for orlistat?

A

pregnancy cat B (but not recommended)
chronic malabsorption syndrome or cholestasis
do no give with cyclosporine
32 reports of liver injury!

34
Q

What is this:
experimental drug in phase 2 trials for obesity
selective inhibito of methionine aminopeptidase 2 (MetAP2)
reduces lipid and cholesterol biosynthesis
increase fat oxidation and is associated with rapid weight loss
improved LDL levels and C-reactive protein and adiponectin

A

Beloranib

35
Q

What is this:
works on intestinal FXR
better metabolic profiles
high VO2 consumption (enhanced use of sugar and fat)
Increased core body temp
Induced metabolic responses that promot lipolysys and mobilize fatty acids for oxidation I
“browning” of cells in WAT
(brown adipose tissue is metabolically activate and considered to be a good thing, so white adipose tissue cells act more like brown with this drug)

A

Fexaramine (FXR)

36
Q

(blank) is the only FDA approved nonprescription weight loss aid

A

Orlistat (Alli)

37
Q

Many OTC weight loss drugs are associated with FDA warning and alerts such as (blank)

A

hydroxycut

38
Q

Medications with some evidence for modest weight loss at 6-12 months (level 2 evidence) in diabetics are…?

A

Orlistat (Xenical, Alli) FDA approved
Canaglifozin (type 2 diabetes inadequatley controlled with metformine)
Fluoxetine (prozac)

Block 10 Week 2 (7 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions