Obesity Flashcards
condition of excess adipose tissue relative to LBM
obesity
how do we identify overweight and obesity?
BMI, WC
health risks of overweight, obesity:
CVD, type 2 diabetes, non alcoholic fatty liver disease
known causes of obesity explain ____% of cases
<1
examples of known causes of obesity:
genetic syndromes (Prader-Willi), endocrine (Cushing’s), hypothalamic dysfunction (tumours), medications
meds that cause obesity:
glucocorticoids, many psychiatric meds, insulin/thiazolidinediones/sulfonylureas
genes influence:
appetite (leptin), susceptibility to hunger, taste preferences, level of disinhibition, REE (uncoupling proteins), TE of food, nonexercise activity thermogenesis, etc.
early studies of gene influence vs current:
twins and adopted children; obesity gene variants
assessing for risk of chronic disease steps:
assess BMI, measure WC, classify for disease risk, combine info with other risk determinants, FPG, lipid profile, liver enzymes, BP, assess for mood disorders
major depression and mood disorders occur in ___% of women aged 40+ with BMI > 30 kg/m^2
20-60
common barriers to wt loss?
all or nothing mindset, lack of time, loss of motivation, dislike exercise/disability, lack of knowledge, yoyo dieting, low self-efficacy, lack of personal interest
3 components to lifestyle modification:
nutrition, physical activity, CBT
behaviour modification techniques:
self monitoring, stimulus control, modify specific eating behaviours and stimuli, reinforcement management, also stress management
successful wt loss maintenance defined as :
> 5% wt loss from baseline maintained 12 months
why is deficit of 500 kcal/day=1-2 lb a week of wt loss a crude estimate?
assumes that it will be pound in fat (also losing water, protein structure supporting fat)
obesity class 1 , 2, and 3 BMIs:
30-34.9, 35-39.9, 40+
disease risk increased for women of WC > __ cm and men WC > ____cm
88; 102
traditional meds for combating obesity
stimulants, orlistat, alternative treatments
newer approaches combat obesity:
bariatric surgery, brain stimulation (transcranial direct stimulation)
safety concerns for stimulants?
raise BP and HR
this non-stimulant agent inhibits lipases in GI tract, prevents fat breakdown/absorp, minimal systemic absorption
orlistat (xenical)
orlistat also improves;
lipid lvls and BG
side effects of orlistat
flatus with discharge, oily spotting, fecal urgency, fatty oily stool, fecal incontinence, increased defecation, probs with vit absorption
this class of drugs currently under investigation for wt loss, used for diabetes
GLP-1 receptor agonists (receptors for incretin hormones–stim insulin secretion; found on beta cells, glucagon-like peptide-1)
