Obesity Flashcards

1
Q

What are the primary functions of adipose tissue?

A

It serves as a reservoir of readily convertible energy and serves as a heat insulator.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is the formula for BMI?

A

BMI = (Weight in Kg)/(height in meters)(height in meters) which is to say, it is the weight in kilograms divided by the height in meters squared.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What is the formula for ideal body weight?

A

Male ideal body weight in kilograms = height in centimeters - 100. The female ideal body weight in kilgrams = height in centimeters - 105.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What are the classifications of obesity based on BMI?

A

A BMI < 18.5 = Underweight,
18.5-24.9 = Normal
, 25-29.9 = Overweight,
30-34.9 = Obesity Class I,
35-39.9 = Obesity Class II,
> 40 = Obesity Class III (morbid obesity)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What is gynecoid obesity?

A

Gynecoid obesity, also called peripheral obesity, is the deposition of fat primarily in the hips, buttocks, and thighs.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What is android obesity?

A

Android obesity, also called central obesity, is the deposition of fat primarily in the upper body. Compared to gynecoid obesity, it has a higher associated risk for cardiovascular disease.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

How does obesity affect the choice of anesthetic?

A

No difference has been demonstrated in emergence following inhalation versus narcotic techniques. Many clinicians, however, recommend a ‘light’ general anesthetic combined with epidural anesthesia whenever possible as it reduces the need for opioids and facilitates coughing and deep breathing after surgery.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

How should positioning for induction of an obese

patient be carried out?

A

The patient should have the shoulders and head ramped up with the head in sniffing position and the bed should be placed in reverse Trendelenburg to increase the FRC and allow large breasts to fall away from the neck. The acronym HELP may be
used to remember ‘Head Elevated Laryngoscopy Position’ for obese patients.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What measurable characteristic best predicts the
occurrence of a difficult airway in the obese patient? What factors are present in the obese airway that may result in a difficult airway?

A

Neck circumference is the single best predictor of a difficult airway. A neck circumference of 40 cm is associated with a 5% chance of difficult intubation while a neck circumference of 60 cm indicates a 35% chance of difficult intubation. Fat rolls
around the neck restrict neck motion while fat in the airway tissue decreases the glottic opening. Other anatomic abnormalities that are often associated with obesity include reduced temporomandibular and atlantoaxial motion.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What are the risks particular to obese patients

presenting for bariatric surgery?

A
Third-space losses generally exceed blood loss for bariatric procedures. At least one large-bore IV should be started and the patient should be typed and crossed for two units of PRBCs. IV fluids should be warmed and an estimated 10-15
mL/kg/hour of lactated ringer s solution or normal saline should be administered. The most important anesthetic considerations for bariatric surgery often has more to do with the patient class
than the procedure itself. Morbidly obese patients have higher morbidity and mortality rates. They have a higher risk for sleep apnea, decreased chest wall compliance (but normal lung compliance), reduced expiratory reserve volume and reduced functional residual capacity. Hypertension is common in these patients and blood volume and cardiac output increase to
maintain blood flow to the increased adipose tissue. Left ventricular dysfunction may be present, making it difficult for the patient to tolerate increases in blood volume or cardiac depression. Diabetes mellitus is often present and fatty
infiltration of the liver can lead to altered metabolism and unpredictably prolonged drug actions.
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Should obese patients undergo rapid-sequence

induction?

A

Obese patients are assumed to have a full-stomach and at risk for pulmonary aspiration. Because of this, it is generally accepted that patients up to a BMI of 50 should undergo rapid
sequence induction with cricoid pressure. Some clinicians postulate that because of the incidence of difficult airway, patients above a BMI of 50 should undergo awake intubation.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What parameters should be used to calculate drug

dosing in obese individuals?

A

Drugs that are distributed mainly to lean tissue should be dosed according to lean body weight. Drugs that are even distributed to lean and adipose tissue should be dosed according to total
body weight.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Name two anesthetic drugs that should be dosed

according to total body weight in the obese individual.

A

Succinylcholine and dexmedetomidine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

How is the volume of distribution and elimination halflife of midazolam compare between obese and nonobese patients?

A

Both the volume of distribution and the elimination half-life are significantly increased in obese patients, resulting in prolonged duration of action in obese patients. A single intravenous dose
should be based on total body weight, but a continuous infusion should be based on lean body weight.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

How should the local anesthetic dose for epidural

anesthesia be adjusted for an obese individual?

A

Due to fatty infiltration and vascular engorgement of the epidural space, the level and onset of an epidural block can be unpredictable. It is recommended that the local anesthetic dose
be reduced by 20% of that of a non-obese patient.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What diagnostic parameter is the most sensitive
indicator of the effect of obesity on pulmonary
function?

A

Obesity decreases respiratory compliance due to the accumulation of fat on the chest wall, diaphragm, and abdomen resulting in a decrease in functional residual capacity, vital capacity, and total lung capacity. The reduction in functional
residual capacity is due to a reduction in the expiratory reserve volume, which is the most sensitive indicator of the effect of obesity on pulmonary function.

17
Q

How does the degree of obesity and the risk of

pulmonary aspiration correlate?

A

An increase in the BMI by 3.5 increases the risk for pulmonary aspiration by 270%.

18
Q

How does obesity affect the left ventricle?

A

Patients with morbid obesity have a larger total blood volume than non-obese patients to supply the excess adipose tissue. The excess blood volume and resulting increase in preload
causes ventricular dilation and increased left ventricular wall stress (eccentric hypertrophy).

19
Q

What is the incidence of obstructive sleep apnea in
obese patients? How does it affect cardiovascular
status?

A

Patients with obstructive sleep apnea typically develop hypercarbia, polycythemia (not anemia), pulmonary hypertension, and right-sided heart failure as a result.

20
Q

How does obesity affect chest wall compliance?

A

Compression of abdominal, diaphragmatic, and thoracic structures by adipose tissue results in thoracic kyphosis, lumbar lordosis, and fixation of the thorax in an inspiratory position which results in a decrease in chest wall compliance by about
35%.

21
Q

How does obesity affect lung volumes?

A

Obesity results in a decrease in lung inflation. The FRC is decreased to less than closing capacity. The expiratory reserve volume, vital capacity and total lung capacity are also decreased.

22
Q

What are the gastrointestinal considerations in the

obese patient?

A

The risk of GERD, cholelithiasis, and pancreatitis are substantially increased in the obese patient. Nonalcoholic fatty liver disease, which consists of steatosis, cirrhosis, hepatomegaly, abnormal liver enzyme levels, and impaired liver function may be present. The mortality rate of cirrhosis is
approximately twice that in obese patients compared to normal weight patients.

23
Q

Why do liver enzymes tend to be elevated in patients

with morbid obesity?

A

Morbid obesity produces fatty infiltration, inflammation, and necrosis of the liver. Abnormal liver function tests are present in about 1/3 of morbidly obese individuals. Clearance of drugs is
usually not reduced, however. Increased alanine
aminotransferase is the most common abnormality.

24
Q

What ECG changes are often seen in obese

patients?

A

Low QRS voltage, LVH criteria, left atrial enlargment, t-wave flattening in the inferior and lateral leads, and prolonged QT interval.

25
Q

How does obesity affect renal function?

A

Obesity is characterized by an increased glomerular filtration rate, increased renal tubular resorption, and impaired sodium excretion which further worsens hypertension.

26
Q

What are the principal cardiovascular considerations

of obesity?

A

The morbidity and mortality in obese patients centers around cardiovascular disease in the form of ischemic heart disease, hypertension, and heart failure. The formation and maintenance of the extra adipose mass requires an extra 0.1 L/min of cardiac output for each additional kilogram of fat.
Chronic respiratory insufficiency results in a compensatory increase in blood volume. The increased workload results in increased oxygen consumption and carbon dioxide production,
increased left ventricular pressure and hypertrophy.
Hypertension is more than twice as common in obese patients. Hypercholesterolemia is usually present. Arrhythmias occur as a result of hypoxemia, sleep apnea, electrolyte disorders,
ventricular hypertrophy, and CAD.

27
Q

How does obesity hypoventilation syndrome (OHS)

differ from obstructive sleep apnea (OSA)?

A

Obesity hyperventilation syndrome is equally common among males and females, exhibits an awake PaCO2 that is at least 45 mmHg, exhibits pulmonary hypertension that is more common
and more severe than that seen with obstructive sleep apnea, and doesn’t exhibit nocturnal airway obstruction unless concomitant OSA is present. Obstructive sleep apnea exhibits a normal awake PaCO2 that increases during sleep-induced
obstruction, can exhibit pulmonary hypertension but is less common than OHS, and occurs more frequently in males than females.

28
Q

How does obesity hypoventilation syndrome differ
from the respiratory changes associated with simple
obesity?

A

With simple obesity, the PaCO2, pH, and pulmonary compliance are still in the range of normal values. OHS is present when the morbidly obese patient exhibits inappropriate somnolence, sleep apnea, hypoxemia, hypercapnia, and
decreased alveolar ventilation. Polycythemia, enlarged heart, and cyanosis may also be present.

29
Q

How does hyperinsulinemia contribute to

cardiovascular disease in the obese patient?

A

Hyperinsulinemia activates the sympathetic nervous system, causes sodium retention, and results in an overall 50-60% increase in the incidence of hypertension. The chronic
hypertension leads to concentric left ventricular hypertrophy and an increase in the risk for congestive heart failure.