OB Pharm

Question 1

Indomethacin Contraindications

Answer 1

Platelet dysfunction
Bleeding disorders
Hepatic dysfunction
GI ulcers
Renal dysfunction
Asthma if also sensitive to ASA

Question 2

DOC at 24-32 weeks gestation for Preterm Labor

Answer 2

Indomethacin a prostaglandin inhibitor through inhibition of cylooxygenase

Question 3

NIfedipine Contraindicaitons

Answer 3

Hypotension, preload dependent cardiac lesion, use cautiously in LV dysfunction or CHF
Dose
**Do not use in conjunction with magnesium sulfate as they can act synergistically to suppress muscle contraction and result in respiratory depression

Question 4

DOC at 32-34 weeks gestation for preterm labor

Answer 4

NIfedipine a Beta-adrenergic receptor agonist

Question 5

group B strep treatment

Answer 5

Penicillin G OR Ampicillin
PCN allergic patients:
Low risk for anaphylaxis
Cephazolin (Ancef)
High risk for anaphylaxis to PCN then use:
Clindamycin (if known to be susceptible)
OR Vancomycin

Question 6

Post partum hemorrhage uterotonic drugs

Answer 6

Oxytocin is the uterotonic DOC
Add Misoprostol
Add Methylergonovine
Add Carboprost tromethamine (Hemabate)

Question 7

Adverse effects of elevated magnesium levels

Answer 7

Plasma level 4 mEq/L : Deep tendon reflexes decrease
Plasma level of 8-10 mEq/L: Deep tendon reflexes absent
Plasma level 10-15 mEq/L: Respiratory Paralysis
Plasma level 20-25 mEq/L: Cardiac arrest
Calcium gluconate 1 g IV over 10 min to treat toxic levels of magnesium