Ob flash cards 20160824
What precursors does the placenta use to produce progesterone, and where do these come from?
What about for estrogen?
Progesterone precursor: Maternal cholesterol
Estrogen precursor: DHEA produced by fetal adrenal cortex (inner/fetal zone)
(So fetal development makes more estrogen precursors available)
(Fetus cannot convert progesterone to estrogen due to lack of 17alpha-hydroxylase)
What maneuver can be used to prevent anal sphincter tears?
Modified Ritgen maneuver: finger in anus lifts up fetal chin
What is commonly found on cardiac exam in pregnancy?
Systolic ejection murmur, S3 gallop, increased S2 splitting
What category is recurrent late FHR decels associated with?
Category 2 unless accompanied by absent FHR variability, in which case is Category 3
How is arrest in active phase of stage 1 defined?
StepUp: No cervical change for 2 hours
However, ACOG defines a longer threshold for indicating possible C-section:
No cervical change for 4 hours despite adequate contractions
OR
No cervical change for 6 hours with inadequate contractions managed with oxytocin
How are Montevideo units calculated? What should the value be with optimal contractions?
Sum of contraction amplitudes of all contractions in 10 minutes (in mm Hg, from IUPC).
Should be >200 MVU
What previous C-sections allow for TOLAC? CI TOLAC?
Allowed: One previous low transverce CSX
CI: Vertical or T-shaped incision, multiple CSX
What is uterine massage used to treat?
Uterine atony in stage 3
What are the implications of arrested or protracted 2nd stage of labor?
Does not require C-section unless fetal heart rhythm non-reasusring or cephalopelvic disproportion (CPD) has not been ruled out.
How is Circulation managed during additional resuscitation in the immediate neonatal period?
If HR
What category is variable FHR decelerations with shoulders associated with?
Category 2
What is Chadwick’s sign?
Bluish discoloration of labia, vagina, and cervix.
From 8-10 weeks’ gestation
How often should the FHR be evaluated in 1st and 2nd stages of labor, with and without risk factors?
1st stage: every 30 min w/o risk factors, every 15 min w/ risk factors
2nd stage: every 15 min w/o risk factors, every 5 min w/ risk factors
How is a variable deceleration defined, in terms of:
1. Time to peak
2. Minimal amplitude
3. Duration
4. Association with contractions
- Time to peak within 30 s
- Amplitude: 15 bpm or more
- Duration: 15 s or more, 2 minutes or less.
(Sort of the opposite of an accel)
What are the frequency and intensity of “optimal” contractions?
Frequency: 3-5/min
Intensity: 50-60 mm Hg by IUPC
(At least 200 MVU)
When is fetal heart activity detected by electronic Doppler by?
12 weeks
What triggers increased flexibility of the pubic symphosis during pregnancy?
Relaxin (produced by placenta0=)
What nerve roots carry pain signals in 1st and 2nd stages of labor?
1st: T10-L1 visceral (contraction and dilation pain)
2nd stage: S2-S4 somatic (Pudendal n.)
What are early signs of pregnancy on physical exam?
Cervix softens (Goodell’s sign) - 4 weeks’ gestation
Uterus sogtens and seems to be separate from cervix (Hegar’s sign) - 4-6 weeks’ gestation
Bluish discoloration of labia, vagina and cervix (Chadwick’s sign) - 8-10 weeks’ gestation
What is normal pCO2 and bicarb on maternal ABG in late pregnancy?
pCO2: 25-33 (decreased)
Bicarb: 16-22 mEq/L (decreased)
Where is corticotropin-releasing hormone (CRH) produced?
Placenta (as well as maternal hypothalamus)
What is the path of blood from the umbilical vein to the IVC in the fetus?
50% goes via ductus venosus directly into IVC.
50% goes through portal veins, through liver, then hepatic veins, then to IVC.
How long of a time period do you need to use to assess baseline FHR?
10 minutes
What can meconium aspiration be an indicator of?
Fetal distress
What hormone induces maternal insulin resistance to make glucose available to the fetus?
Human Placental Lactogen (HPL)
What are the most common causes of overestimation of fetal descent?
Caput succedaneum (scalp edema) and molding of the skull
What stimulates increasing cortisol levels late in pregnancy? What opposes it?
Positive feedback loop:
Placental CRH stimulates fetal ACTH, which stimulates fetal cortisol production, which stimulates placental CRH production.
Progesterone suppresses placental CRH
What category tracing is absent baseline FHR variability associated with?
Category 3 is also have bradycardia or recurrent late or variable decels
Category 2 otherwise.
How is fetal station scored for the Bishop score?
0: -3 (-5 cm)
1: -2 or -1 (-4 to -1 cm)
2: 0
3: +1 or more (+1 cm or more)
How often should prenatal visits occur during uncomplicated pregnancies?
Every 4 weeks in first and second trimesters (until 28 weeks)
Then every 2-3 weeks until 36 weeks
Then every week until delivery
What category is recurrent FHR accels associated with?
May or may not be seen in category 1
What is the normal umbilical artery pH, PCO2, and bicarb?
pH 7.25-7.30
PCO2: 50 mm Hg
Bicarb: 25 mEq/L
How do Braxton-Hicks contractions and true labor contractions differ with respect to exercise?
Braxton-Hicks contractions: much less noticeable with exercise
True labor contractions: equally noticeable with exercise
What is a fetal biophysical profile (BPP) used for?
To guide whether or not to induce labor
When is the pregnant uterus usually palpable at the pubic symphosis?
12 weeks
What is the implication of a FHR acceleration?
Reassuring. FHR able to respond to stress of uterine contraction.
When is fetal biometry performed? What 4 things are measured?
18-20 week ultrasound in 2nd trimester.
Measure:
1. Biparietal diameter (BPD)
2. Head circumfrence (HC)
3. Abdominal circumference (AC)
4. Femur length (FL)
What medication is used to induce labor with a favorable Bishop score?
IV Pitocin
(Amniotomy may also be used)
What effects do estrogen and progesterone have on the breast?
Estrogen stimulates ductal growth
Progesterone stimulates alveolar hypertrophy
What medications are used to treat uterine atony (5)?
Uterotonics include:
1. Pitocin / oxytocin
2. Carboprost (hemabate): PF2alpha analog
3. Misoprostol (cytotec): PE1 analog
4. Methylergonovine (methergine)
5. Ergonovine
What neurologic complication can result from fetal ischemia around birth? How does it present?
Hypoxic-Ischemic Encephalopathy (HIE)
Presentation: difficulty breathing, depressed tone, abnormal level of conciousness, and/or seizures
How is a FHR acceleration defined, in terms of:
1. Time to peak
2. Minimal amplitude
3. Duration
- Time to peak within 30 s
- Amplitude: 15 bpm or more, OR if
How are maternal renin and angiotensin changed in pregnancy?
Greatly increased - renin by 10x, angiotensin by 5x
What is the maximum Bishop score?
13
Indications for first C-section (6)?
- Placenta previa
- Placental abruption
- Umbilical cord prolapse
- Labor arrest
- Nonreassuring fetal status
- Breech position
What fetal maneuvers can be used to dislodge fetal shoulder during fetal distocia? (3)
- Rotating shoulder
- Delivering posterior arm
- Manually fracturing clavicle
What is commonly found on EKG in pregnancy?
Left axis deviation due to physiologic LV and LA hypertrophy
(May also lead to enlarged cardiac silhouette on CXR)
When does the neural tube close?
Closes by 6 weeks’ gestation (from 24-26 days after conception)
What is the implication of face presentation?
Requires C-section unless in anterior mentum position (chin is towards abdomen)
When Is nuchal transclucency assessed?
First trimester ultrasound
How are the different levels of FHR variability defined?
Which is best? Worst?
Absent: None disernible
Minimal: 5 bpm or less
Moderate: 6-25 bpm
Marked: 25 bpm or more
Moderate is best, absent is worst, minimal is 2nd worst
What is the implication of a variabl FHR deceleration?
Non-reassuring: category 2 tracing, or category 3 if also absent FHR variability.
Suggests cord compression.
What are the Bishop score thresholds for a favorable and unfavorable cervix?
Favorable: 8 or more
Unfavorable: 6 or less (some used 4 or 5 or less)
What is the implication of a late FHR deceleration?
Non-reassuring: category 2 tracing, or category 3 if also absent FHR variability.
Suggests placental insufficiency (response to hypoxia after compression)
What is the implication of vertex presentation?
Ideal
What is the treatment for neonatal respiratory depression after maternal narcotics?
Naloxone
What category tracing is marked baseline FHR variability associated with?
Category 2
What are the genetic screens of pregnancy, and when are they performed?
First trimester screen: 10-13 weeks
beta-HCG and PAPP-A
Second trimester screen: 15-21 weeks
Triple screen (AFP, estriol, hCG) or quad screen (add inhibin)
What is the threshold for neonatal metabolic acidosis based on umbilical artery gas?
pH 16)
What is done to treat nonreassuring FHR pattern?
(5)
- Mother in left lateral position
- Administer maternal O2
- Correct any maternal hypotension
- Discontinue oxytocin
- Treat uterine tachysystole (5 or more contractions in 10 minutes) with terbutaline (beta agonist)
(If does not resolve, expedite delivery)
How is arrest of fetal descent defined, for primi/multigravid and with and without epidural?
Premi w/ epi: > 3 hrs
Premi w/o epi: > 2 hrs
Multi w/ epi: >2 hrs
Multi w/o epi: >1 hr
(This is per First Aid - UpToDate times are 1 hour longer)
What are the 3 most common causes for primary C-section?
- Labor arrest (34%)
- Nonreassuring fetal tracing (23%)
- Malpresentation (17%)
(Others include multiple gestation (7%), macrosomia (4%), and preeclampsia (3%))
What are the risks of amniotomy for augmenting protracted active phase? (2)
- Cord compression or prolapse
- Chorioamnionitis (if labor is prolonged)