OA: Med Safety Flashcards
GI changes in OA regarding medications
- decreased acidity
- decreased blood flow to GI tract and GI motility delay the time it takes for meds to absorb
Fat/water distribution in OA regarding medications
-more fat, less water
Decreased available proteins lead to…
levels of unbound drug increase in blood stream
Renal function and OA meds
-decrease in renal function means drug not eliminated and drug level increases
decreased renal function —> increased drug levels
Liver function and OA meds
decreased hepatic enzymes —> increased drug levels
Functional decline in OA
- cognition
- taste
- hearing
- manual dexterity
- vision
Polypharmacy
use of four or more medications by a patient, generally adults aged over 65 years
Risks with polypharmacy
increased risk of ADRs and drug interactions
Causes of polypharmacy
- comorbidities
- multiple providers
- herbal therapy
- OTC meds
- “discontinued” rx drugs
ADRs
Adverse Drug Reactions
-3 to 4x greater than those in middle-aged and young adults
Reasons for ADRs
- increase number of prescriptions
- physiologic changes (general and individual)
- therapeutic ranges may lead to toxicity
Causes of ADRs
- living arrangements
- multiple providers
- incorrect/inappropriate drug dosing
- providers unaware of self-med habits
Self-med Practices
- OTC
- herbals
- rx meds
- non-adherence of med regimen
- expired meds
Ways OA do not adhere to medication regimen
- overuse
- underuse
- erratic use
- confusion or lack of knowledge
- financial (“stretch out” meds to last longer)
Types of ADRs
- falls
- bleeds
- confusion
- renal/liver impairment
- electrolyte imbalances
- orthostatic hypotension
- drug to drug interactions
National Patient Safety Goals for Safe Med in OA
- take extra care of patients who take medicines to thin their blood
- record and pass correct info about meds
- find out what meds pt is taking
- compare meds to new meds given to the patient
- make sure pt knows what meds to take at home
- tell pt it is important to bring up-to-date meds every time they visit the doctor