O&G Flashcards
Cancer screening:
- cervical
- breast
-bowel
-targeted lung
Cervical: every 3 years (25-49yo), every 5years (50-64yo)
Breast: every 3 years(50-70yo)
Bowel: one off flexisig 55yo, home kit (FIT test) every 2 years (60-74yo in England).
Targeted lung: low dose CT scan offered to 55-74yo at high risk of cancer & reinvited every 2 years
How do you test if someone has ovarian failure as a cause of secondary amenorrhoea?
FSH>=20IU/l
Emergency contraception ?options
(UPSI - unprotected sexual intercourse)
FIRST LINE - Copper IUD: use 5days post UPSI or within 5days of expected ovulation. Directly toxic to sperm, reduce sperm numbers that reach uterus, damage embryo before implant, interfere with implantation.
Levonorgestrel: progesterone only pill. Used within 3days of UPSI. Inhibit ovulation.
Ullipristal acetate: selective progesterone receptor modulator. Use 5days UPSI. Inhibit/delay ovulation.
Causes of post coital bleeding
Cervical ectropion (most common)
Vaginits
Vaginal cancer
cervical cancer (most malignant cause)
Cervicitis
Cervical polyps
Trauma
Types of miscarriage: threatened, complete, incomplete, missed, inevitable
Threatened: minimal pain, less bleeding compared to menstruation, closed cervix, fetal heart visualised
Complete: no pain, less bleeding compared to menstruation, closing cervix, empty uss
Incomplete: pain +/-, a lot more bleeding compared to menstruation, open cervix, retained products/no fetal heart
Missed: no pain, minimal bleeding, closed cervix, small uterine size, no fetal heart
Inevitable: pain +, more bleeding compared to menstruation, open cervix, fetal heart may/may not be visualised
Normal physiological changes of blood test when comparing pregnancy and pre-pregnancy state
Hb drops
Haematocrit drops
WBC increase
Platelet count drops
Urea and creat drops
GFR increases
Albumin, ALT, AST drops - dilutional effect
ALP rise due to placental production
Cause of chancroid
Haemophilia ducreyi
-painful genital ulcer
- tender inguinal lymphadenopathy
Cause of chancre
Treponema pallidum (syphilis)
- small painless ulcer
Cause of strawberry cervix
Trichomonas vaginalis
- frothy greenish discharge with fishy odour
- tx: metronidazole
Cause of lymphogranuloma venereum
Chlamydia trachomatis
- painless genital ulcer
- painful lymphadenopathy ‘buboes’ or abscess
Risk factor for endometrial cancer
Obesity
Nulliparity
Late menopause
Fhx
Tamoxifen
HRT
Pelvic irradiation
Diabetes
Pcos
Red degeneration of fibroid
Degeneration of myoma
Uss shows mixed echodense or echolucent appearance
Tx: supportive - analgesia, rehydration
How to check cervical ripeness?
PEDSS
Position
Effacement
Dilation
Softness/consistency
Station of foetus
Risk factor of hyperemesis gravidarum
Nulliparity
Fhx
Personal history
Multiple pregnancy
Female foetus
Age<30yo
Trophoblastic disease
Maternal obesity
Non smoker
Smoking in pregnancy - what are the features?
Miscarriage 2x risk
Preterm labour
Lighter for date babies
Reduced reading ability up to 11yo
Reduced ovulation
Abnormal sperm production
Definition of preterm, term and postterm delivery
<37 week
37-42 week
>42 week
Asthenozoospermia
Oligospermia
Azoospermia
Hypospermia
Teratospermia
Asthenozoospermia: reduced sperm motility
Oligospermia: low sperm count
Azoospermia: no sperm in ejaculate
Hypospermia: reduced semen volume
Teratospermia: poor sperm morphology
Iron supplement - what are the indication during pregnancy
Hb<100
MCV<84
What and when to check that one is ovulating?
Progesterone
Mid-luteal phase (ie one week before period - IE day 21 out of 28day cycle or day 28 out of 35day cycle)
Tx of menorrhagia
Mirena 1st line
Trenaxamic acid
Nsaids - only take during menstruation
Cocp
Norethisterone
Mechanism of action of:
COCP
MIRENA
POP (emergency)
Cocp- prevent ovulation via HPO axis
POP (except desogestrel)- increase volume and viscosity of cervical mucus, endometrial changes, reduction in cilia activity
POP (desogestrel): suppress ovulation, also thickens cervical mucus
Mirena- changes to cervical mucus, endometrial changes (atrophy)
Copper coil - toxic to ovum and sperm, anti-implantation effect
Pop (emergency)- delays ovulation, prevent follicular rupture and causes luteal dysfunctuon
Ullipristal (emergency) - delays ovulation for at least 5 days
Difference between lentigo and malasma
Lentigo - flat brown lesions which do not darken in sun exposure
Malasma aka chloasma - macules and larger patches that is brought on by pregnancy or sun exposure
Test for downs
Combined testing - mum’s age, nuchal translucency, HCG, Papp
If greater than 1:200, offered either chorionic villus sampling (<13 weeks) or amniocentesis (>15 weeks gestation)
When & whom do you give anti -d
Rhesus negative mothers
28 & 34 weeks
Definition of:
Dysmenorrhagia - primary Vs secondary
Menorrhagia - metrorrhagia, menometrorrhagia, dub
Primary dys - cramping pain due to menstruation (NO pelvic pathology)
Secondary dys - menstrual related pain due to another medical or physical condition such as endometriosis/fibroids
Metrorrhagia - breakthrough bleeding either between periods or not related to periods
Menometrorrhagia - heavy and prolonged bleeding that occurs in irregular intervals
Dub - excessive bleeding due to hormonal problems usually lack of ovulation
Placental abruption
Placenta praevia
Vasa praevia
Premature separation of placenta from uterus.
Praevia - implantation of placenta over the internal cervical os.
Vasa - foetal vessels running close to internal cervical os.
Cocp and cancer
HRT and cancer
COCP: Protective for endometrial, ovarian and colorectal cancer. Can increase risk of breast and cervical cancer.
HRT: Increase risk for breast and endometrial cancer.
Tx options of endometriosis
COCP (for those who wanted contraception) or NSAIDs (for those who didn’t want contraception)
Danazol (once tried COCP/POP/NSAIDs but no response)
Oral or depot medroxyprogesterone acetate
Levonorgestrel IUS
GnRH analogues (before surgical procedure)
Laparoscopic ablation (most effective method)
Fibroadenoma Vs lipoma Vs breast cancer in signs
Fibroadenoma - small, smooth, rubbery, firm, mobile. breast mice. Found in 20-30yo
Lipoma - small, mobile, palpable, painless. Found in 40-60yo.
Cancer- dimpling
Fat necrosis - similar to cancer. Only a biopsy can differentiate
Catamenial epilepsy
Seizures linked with menstrual period
Which hormone (sexual) have effect on seizure (specifically the catamenial)?
Oestrogen lowers seizure threshold
Progesterone increases seizure threshold
what is the Amstel criteria?
- clue cells on saline smear
- pH >4.5
- thin, grey and homogenous discharge
- positive whiff test
if 3 or more present, patient has bacterial vaginosis
treatment of maternal hyperthyroidism when pregnant
carbimazole or propylthiouracil
(as these can cross the placenta and cause fetal hypothyroidism)
BUT carbimazole can be teratogenic -> therefore, avoid in 1st trimester & can be started in 2nd trimester.
when would you do block and replace for maternal hyperthyroidism?
when maternal TSH antibody is affecting the fetus (in a mum who had ablative therapy for Grave’s disease) and causes fetal hyperthyroidism.
so give anti-thyroid drug (for the fetus) and levothyroxine (for the mum)
side effect when used during pregnancy
tetracycline -> teeth discolouration- (if taken in 2nd/3rd trimester)
ACEi -> impaired fetal renal function, oligohydramnios, skull abnormalities
Streptomycin -> auditory and vestibular nerve damage
beta-blockers -> intrauterine growth retardation, bradycardia, neonatal hypoglycaemia
NSAIDs -> closure of ductus arteriosus, persistent pulmonary hypertension of newbown, delay labour, impair placenta blood flow
blood-stained discharge from nipple and small lumpy mass
?diagnosis
duct papilloma
local areas of epithelial proliferation in large mammary ducts.
hyperplastic lesions rather than malignant or premalignant
fibroadenosis - what is it?
fibrocystic disease OR benign mammary dysplasia
- seen in middle aged women
- painful, lumpy breast that flare during menstruation