Neurology & Psych (from MCQBank) Flashcards
which population do we not find friedereich ataxia?
east asia (china and japan)
american indians
predisposing factor for bulimia
females
low self-esteem
personal/FHx of depression
personal/FHx of obesity
high personal expectations
FHx eating disorders
parents older than average
disturbed family interactions
early menarche
social pressures to be slim
Time to hold someone under section
- 2
- 3
- 4
- 5(2)
- 5(4)
- 135
- 136
2 = 28days, assessment
3 = 6 months, treatment
4 = 72 hours, assessment
5(2) = in hopital, by doctor, 72 hrs
5(4) = in hospital, by nurse, 6 hours
135 = break into house by police
136 = public place, detained by police, 24hr
Simulated disease divided into:
1. Unconsciously produced (somatoform disorders):
- mainly neurological symptoms - ?diagnosis
- multiple organ systems - ?diagnosis
- Intentionally produced (deception syndromes:
- without external incentives - ?diagnosis
- with external incentives - ?diagnosis
- conversion disorder
- somatisation disorder
- factitious disorder (includes Munchausen sydnrome, by proxy is when someone afflict/create the problem on someone else - usually carer on patient)
- malingering
Treatment of Bell’s palsy (within 72 hours)
oral prednisolone 50mg OD for 10 days
Increased risk factors for those who commit suicide
Male
Repeated self-harm
Has physical health conditions
Express suicidal intent
Schneider’s first rank symptoms of schizophrenia
auditory hallucinations
thought withdrawal, insertion or interruption
thought broadcasting
somatic hallucinations
delusional perception
feelings or actions experienced as made or influenced by external agents
New screening tool for eating disorders
SCOFF
Sick, control, one, fat, food
- have you ever eaten so uncomfortably full that you feel sick?
- do you ever worry that you lost control of what you eat?
- have you recently lost weight or gained more than 1 stone in 3 months?
do you believe yourself as fat when others say you are thin? - would you say that food dominates your life?
> =2 is high risk of eating disorder
Multi-system atrophy - signs and symptoms
Autonomic features (Postural hypotension, urinary dysfunction)
Cerebellar ataxia (poor balance, broad-based gait)
Parkinsonism symptoms (resting tremor, rigidity etc)
Normal pressure hydrocephalus - signs and symptoms
Gait disturbance
Urinary incontinence
Dementia
Arteries or Veins affects:
- subarachnoid
- subdural
- extradural
Subarachnoid: vein?
Subdural: cortical bridging veins
Extradural: artery?
Treatment of trigeminal neuralgia
Carbamezepine (also oxcarbamezepine)
?TCA
?Lamotrigine/Baclofen
Cataract, muscle weakness, balding - ?diagnosis
myotonic dystrophy
inheritance pattern for myotonic dystrophy
autosomal dominant
also, has anticipation - ie earlier for successive generations
Inheritance pattern of Freiderich’s ataxia
autosomal recessive
Clinical features of borderline personality disorder
4 main clinical features/areas:
- Emotional instability (affective dysregulation)
- Disturbed patterns of thinking or perception (cognitive distortions or perceptual distortions)
- Impulsive behaviour
- Intense but unstable relationships
Difference between baby blues, postnatal depression and puerperal psychosis
Baby blues - high OR low mood, within 10 days post-delivery. no specific tx as care of baby is not impaired.
Post-natal depression - occurs within 12 months of delivery. low mood, anhedonia, weight changes, sleep disturbance etc. need to be treated as can cause substantive impairment for mum and impaired behavioural/emotional/cognitive changes for baby
Puerperal pyschosis - aka post-partum psychosis. has hallucinations, severe thought disturbance and abnormal behaviour soon after birth. high risk for those who have history of bipolar disorder or previous puerperal psychosis. seek urgent specialist advice
Serotonin syndrome - what is it?
- neuromuscular excitation
- autonomic effects (blurred vision, tremor, myoclonic jerking, tachycardic, hyper-reflexia, ankle clonus)
- altered mental status
Neuroleptic malignant syndrome - what is it?
due to dopamine antagonist (eg anti-psychotic, metoclopramide)
hyperthermia, muscle rigidity, altered mental status, sympathetic nervous system lability, hypermetabolism, elevated creatine kinase
Tx: stop dopamine antagonist (OR start dopamine agonist), rehydration, cooling, tx of rhabdomyolysis (if applicable)
malignant hyperthermia - what is it?
due to inhaled anaesthetics or succinylcholine (suxamethonium)
thought to be autosomal dominant in RYR1
muscle rigidity, tachycardia, hyperthermia, mixed metabolic and respiratory acidosis
tx: dantrolene, cooling, IVI
patient recently started with SSRI for depression. 3 months later she is completely cured. what is the next step?
continue the SSRI for a further 6 months (following remission of symptoms)
started clozapine for schizophrenia. then developed sore throat - what is happening?
neutropenia side effect
check FBC weekly for the first 18 weeks then fortnightly for next 34 weeks then monthly
reduced visual acuity and colour perception (esp red)
orbital pain worse with exercise
pupillary light defect present
swollen optic disc
?diagnosis
optic neuritis
what is Urthoff phenomenom?
visual loss/neurological symptoms worsenign due to heat or exercise
due to optic neuritis
what is Pulfrich phenomenom?
objects moving in the straight line appear to have a curved trajectory
what is Lhermitte’s sign
shock like sensation radiation down spine due to neck flexion
seen in MS
what anti-depressants to give to breastfeeding ladies?
sertraline or paroxetine
how to create Wernicke’s encephalopathy?
when we give glucose infusion to a patient with chronic thiamine deficiency - therefore, causing thiamine deficiency even further
First line treatment for:
- generalised tonic clonic seizure
- absence seizure
- sodium valproate. if not, lamotrigine
- ethiosuximide
Treatment for tonic clonic seizure for >5min or >3 in an hour
Buccal midazolam
Rectal diazepam if above is not available.
IV lorazepam if there is IV access.
Dementia with myoclonus - ?diagnosis
Creutzfeldt-Jakob disease
For unprovoked seizure- what are the risks for another seizure to occur?
30-50%
after a 2nd unprovoked seizure, this would become 70-80%
recurrent attacks of eye pain for 30min over last few weeks - then followed by lacrimation. often circadian rhythm.
?diagnosis
cluster headache
treatment of cluster headache
acute attack: nasal sumatriptan, oxygen
prophylaxis: short course of prednisolone or verapamil
risk factors of schizophrenia
migration from developing countries (3-fold increase in risk)
children of migrants (second-generation)
urban living (2-fold)
south asian and black population
male (1.4:1)
younger for males (25y/o) and older for female (35y/o)
exposure to Toxoplasma gondii
how does AVPU correspond to GCS?
A - 15
V - 13
P - 8
U - 3
MRC grades of power
0 - none
1 - flicker
2 - with gravity
3 - against gravity
4 - against resistance
5 - normal
what is Pick’s disease?
frontotemporal dementia with inappropriate behaviour
Gait disturbance, urinary incontinence, dementia
Normal pressure hydrocephalus
the 2 main symptoms/criteria for depression are.. ?
low mood
loss of interest or pleasure
Toxicity level for TCA?
> 10mg/kg
Signs and symptoms for TCA toxicity
dilated pupils
dry mouth
drowsiness
tachycardia (sinus)
urinary retention
increased tendon reflexes
extensor plantar responses
Tx of mania
2nd generation or atypical antipsychotics (olanzapine, quetiapine, risperidone) - reduced extra-pyramidal side effect
Lorazepam to aid sleep/reduce agitation
Mood stabiliser eg lithium
Carbamezepine can be used as first line
Rapid tranquilisation
tx of schizophrenia
newer atypical antipsychotics (risperidone, olanzapine) - but the problem with this is weight gain and increase incidence of T2DM and rarely bone marrow depression
depot formulations should be considered
problems associated with sleep for Parkinson’s disease
movement disorder during sleep - nocturnal akinesia (difficulty turning or rising from bed, early morning dystonia, painful cramps and tremor)
circadian rhythm disorders
REM sleep disorder
how does periorbital ecchymosis looks like? and what is the underlying pathology?
panda eyes
basal skull fracture