o&g Flashcards
SGA
<10th percentile
symmetrical: TORCH, syndromes, TTTS
asymmetrical: placental insufficiency
maternal and foetal factors
rfs at booking -> 20 weeks foetal biometry –> normal: 2 weekly USS, abnormal: weekly USS + twice weekly doppler
delivery by 37 weeks
20-24 uterine artery doppler
Vasa praevia
ROM –> painless PV bleeding –> foetal bradycardia
prophylactic hospitalisation at 30-32 weeks
elective c section at 34-36 weeks
emergency c section during labour
12-24 hours apart corticosteroids
Oligo/ Poly
Potters: limb abnormalities, lung hypoplasia, renal agenesis
<2cm/5th percentile; >8cm/95th percentile
ROM is cause
amnioreduction/ cox inhibitors
placental abruption is comp
CTG, USS, Doppler, liquor volume
GORD and resp compromise in mother
LGA
molar preg
serum BHCG
foetal biometry, abdo circum , foetal weight
4kg/ 4.5 kg
>24 <36 weeks = if accelerated, OGTT and foetal
>36 weeks gestational OGTT
OGTT
counsel risks of delivery
perineal tears
metartus adductus
diabetes comps
Obstetric Cholestasis
PPH
dark urine pale stools, liver symps
weekly LFTs, twice weekly Doppler and CTG
chlorphenamine
no rash
IOL at 37 week
coag screen
Acute liver disease
Emergency
immediate delivery regardless of GA
give MgSO4, steroids, glucose, check coagulopathy - may need phasmapharesis
uric acid is high, low glucose
third trimester
Emergency contraception
ullipristal = 120 hours, wait 5 days before hormonal (use barrier)
even if within 3 days, if ovulation occured give IUD
can start hormonal contraception immediately after levonelle
if >26 BMI, >70kg - double dose = 3mg
can use IUD within 5 days of ovulation date too
give prophylactic antibiotics if increased risk of STIs
Mastitis/ breast abscess
antibiotics started if not imrpoved after 12-24hrs of milk expression, infected nipple fissure, breast milk culture +ve
admit if immunocompromised, septic
PID
Fitz-Hugh-Curtis = violin strings
6 months of partners
72 hours then 2-4 weeks
no sex until treatment finished
admit if septic, high fever, oral Ab failed, ectopic, pregnant, abscess
IV gentamicin/ clindamycin
alternative: metronidazole and ofloxacin
Endometriosis
subfertility: laporoscopic ablation and endometrioid cystectomy
clear and endometrioid ovarian carcinoma association
IBS and constipation
powder burns, retroverted uterus
3 month trial
give COCP in addition to ablation to stop recurrence
Adenomyosis
MRI
linear striations
boggy uterus
multiparous perimenopausal woman
hysterectomy is definite
think c section then heavy painful periods
Fibroids
No Mirena if pedunculated
Leiomyosarcoma
uterine artery embolisation - preserve uterus not fertility
>3mm = refer to specialist
irregular bleeding after Mirena for 6 months
no conceiving for 6 months after myomectomy
GnRH agonists only for 3 months
in preg, may affect, mostly can do vaginal, iron supplements
regress post-menopausal
smooth muscle origin = smooth round, gray-white tumours
red degen = severe abdo pain, post partum torsion
Endometrial hyperplasia
with atypia/ without atypia (pipelle biopsy/ hysteroscopy after TVUSS)
if without atypia: Mirena, surveillance every 3-6 months
atypia: hysterectomy + BSO
>10mm for premenopausal
Endometrial cancer
type 1 is superficial invasion, low grade, PTEN
type 2 is deeper, high grade, p53
stage 1: total abdo hysterectomy + BSO
stage 2: radical hysterectomy + radiotherapy
VIN and vulval cancer
Warty/basaloid type: VIN, HPV 16, immunosuppression, smoking
Keratinised: lichen sclerosis
full thickness biopsy
1a = <1mm depth, <2cm size = wide local incision
>1b: radical vulvectomy and bilateral inguinal lymphadenectomy
Figo:
1a/1b
II: lower 1/3rd vagina
III: lower 1/3rd vagina and lymph nodes
IV: upper 1/3rd
IVb: mets
rule out cervical
Ovarian cysts
follicular: granulosa, corpus luteal: luteal
<5, 5-7 (yearly USS), >7 (MRI +/- surgery); cystectomy also if multifocal .etc.
if recurrent = COCP
post: RMI > 200 vs <200
<200 = unchanged (CA125, USS 4-6 months), changed (cystectomy), resolved
if bilateral, symptomatic, multifocal, not simple, >5cm = only BSO
BSO + omentectomy + TAH = >200
if rupture: pain relief and observe, if bleeding - can do cautery
LDH = dysgerminoma
aFP = teratoma, yolk sac
bHCG = choriocaricoma, dysgerminoma
MDT!!
luteal in preg
Ovarian carcinoma
Epithelial: serous, mucinous, clear cell, endometrioid (malignant)
Germ cell (eosinophils): teratoma mature = benign, immature = malignant), dysgerminoma, choriocarcioma
sex cord: Leydig, granulosa, thecoma, fibroma (Meig’s - spindle shaped fibroblasts)
should not biopsy
carboplatin
in sex cord - chemo not useful
figo: 1a =1 ovary, 1a = both, 1c = capsule ruptured, II: pelvis, III: peritoneum, IV: mets
>=35 = referral
if mass = immediate referral
Cervical cancer and CIN
1a = LLETZ/ cone
1b-11a = radical trachelectomy (fertility sparing), radical hysterectomy <=4 if > then chemo
then chemo and radio
koilocytosis
if hysterectomy, follow up 6 and 18 months to check residual cells = vault smear
test for cure = 6 months later, routine recall of 3 years after regardless of age if negative
CIN 1 = 12 weeks
delay to 3 months post partum
if HPV +ve, cytology -ve, repeat 12 months later, if 24 months later still same –> colposcopy
I = cervix, II = upper, III = pelvic wall and lower, IV = mets
BV
loss of lactobacilli
Amsel’s = thin white, clue cells, 10% KOH smell, high pH > 4.5
copper IUD
Chlamydia
NAAt of first catch urine or vulvovaginal swab
doxy for 7 days
azithromycin in preg/ neonates
cant see under microscopy
General STI counselling
STI screen
protection
no sex until treatment complete
contact tracing (6 monts)
impact on partner and pregnancy
follow up
Gonorrhoea
ceftriaxone
can do direct microscopy
Trichomonas
wet mount
green yellow frothy
high vaginal swab
Candidiasis
clotrimazole pessary
HVS microscopy - pseudohyphae
Syphilis
takes 3/12 weeks
treponamel pallidum
dark field - dark ground appearance of chancres under microscopy
Jarish-herxheimer - give steroids before benzatheine-pen
IM stat in 1st, 2/3rd = IM, IV in neuro
primary - painless chnacres and local lymphadenopathy
secondary - snail track ulcers, papulonodular rash, condylomata lata
tertiary - gummatous, cardio - aortic regurg, neuro - dementia, labile emotions, lightning pains
non-treponemal - RPR, VDRL
treponemal - EIA
repeat bloods at 6 and 12 weeks
if myalgia - admit mothers after 22 weeks
HSV
<26w= 36 weeks to delivery = oral daily + VSD (IV acyclovir intrapartum and neonate)
>26w until delivery = c section + acyclovir
recurrrent - daily until delivery from 36 weeks
SEM, CNS, disseminated
avoid forceps
HPV
Keratinised warts = imiquimod cream
Non-keratinised warts = podophyllin/tri-chloro-acetic acid
dermatoscopy
VZV
need to check Ig first
if not, give IVIG
if <20 weeks or > 20 weeks, within 10 days exposure, no symps
oral acyclovir if >20 weeks, within 24 hours
foetal specialist unit 16-20 weeks/ 5 weeks after infection
<7 days of delivery/ rash - IVIG to neonate
if neonatal infection = oral acyclovir
congenital: cataracts, microcephaly, limb hypoplasia, IUGR
neonate: purpura fulminans, pneumonia
15 mins contact can be contagious
monitored until after 28 days
Breech
high risk vaginal: hyperextended neck, LBW, HBW, footling, foetal compromise
CI for ECV: antepartum haemorrhage in prev 7 days, ROM, indications for c-section, multiple preg, abnormal CTG
36 - nulli. 37 - multi
hands off approach, Pinard - poke politeal bend knees, Loveset - transverse + anterior arm
if head stuck - winging of scapulae
C section -ves: normal c section risks, uterine rupture, placenta accreta .etc.
+ve: better APGAR, perinatal mortality better
tocolytic like terbutaline can improve success rate of ECV
TOP
o Pregnancy test
o Scan
o Height, weight, bloods and urine dip with nurse
o STI screen
o Speak with a counsellor regarding your reasons, options available and future contraception
Antibiotics are given to reduce risk of infection
chance of ectopic, 24 hr help line
HSA 1 and HSA 4
expulsion at home, <14 weeks MVA, > 14 weeks dilatation and curetagge
more painful as further along
antiibiotics and painkillers
anti D >10 weeks or any surgical
4 weeks = chorio, ectopic
24-48 hours apart, 10-23 = 36-72, >21 = feticide = digoxin, KCl/ regular interval misoprostol (max 5 doses)
urine preg usually 2 weeks after
DVT
CXR, ECG
eleavte legs
USS:
· If -ve and low clinical suspicion à stop anticoagulants
· If -ve and high clinical suspicion à stop anticoagulants and repeat USS on days 3 and 7
Subcutaneous LMWH until at least 6 weeks postnatally and until ≥3 months of treatment
until at ≥24 hours after last dose of LMWH
stop 24 hours before
at term = IV unfractionated
Prevention at 12w BOOKING visit:
· Prolonged use of LMWH (>12 weeks)
· Graduated elastic compression stockings
Graduated elastic stockings should be used initially and worn for 2 years following DVT to prevent post-thrombotic syndrome
· From 12w until 10 days to 6 weeks post-partum ≥4 risk factors, VTE event
· From 28w until 10 days post-partum 3 risk factors
Conservative <3 risk factors
<50, >90
Cancers and COCP
protective against endometrial and ovarian
inc risk of breast and cervical
Rubella
<12 weeks : CRS - PDA, microcephaly, cataracts
12-20 - chorioreitnetitis - cataracts
>20 weeks - low risk
forcheimer spots
foetal specialist unit and HPU
no MMR
IgM and IgG and PCR
no work until 5 days after rash
TOP if < 16 weeks
parvovirus B19 serology
Obesity
> 30
dietician referral
good diet and exercise
anaesthetic review >40
IOL discussion to avoid c-section
5mg folic acid 1 month before conception
150mg aspirin
diabetes screening
from 24 weeks do USS instead of SFH
TVUSS for nuchal translucency instead of transabdo
35 obstetric consutant led
constant foetal monitoring
active management of 3rd stage
bacteriuria and UTI
nitrofurantoin, trimethoprim after 12 weeks
IV cefuroxime if admitted otherwise PO cefalexin in pyelonephritis
urinalysis in every antenatal appointment
urine MCS at booking
preterm and pyelonephritis
nitrofurantoin at term = neonatal haemolysis
ectopic
no sex for 3 months, no alcohol, sensitive to sun
weekly serum bhcg until negative
pregnancy test after 2 weks
metho CI in surgical requirements, liver disease, intrauterine preg, breastfeeding
>63, 50-63, >50
no kleihauer, 250 IU of anti-D
syncope, fatigue
copper IUD not used if have salpingectomy
infertility
hypogonadotrophic hypogonad, normo nromo = PCOS, hyper hypo, also hypothyroid
previous pelvic/ abdo surgery
asherman’s
septate can be corrected for
varicocoele
lifestyle - acholo, drugs
semen analysis done 3 months apart
mid-luteal progesterone not in POI
if unexplained try another 12 months
ovarian induction = clomiphene (OHS)
intrauterine - mild endo, not responsive to OI
LH and FSH only in irregular periods
can do laporoscoipic dye to check tubal abnormalities
IVF
o Women <40 offered 3 cycles of IVF if…
§ Subfertility for 2 years
§ Not pregnant after 12 cycles of artificial/intrauterine insemination
o Women 40-42 offered 1 cycle of IVF if…
§ Subfertility for 2 years and/or not pregnant after 12 cycles of AI
§ Never had IVF
§ No evidence of low ovarian reserve
Informed about additional implications of IVF at this age
if children with another partner, dont give
Contraception
COCP: none in first 5 days, any other time 7 days barrier
red risk of ovarian and endometrial
tricyclic or three weeks and 1 week off
stop 4 weeks before surgery switch to POP 2 weeks after
UKMEC
1 pill vs 2 pills missed
POP: immediate protection if switch from COCP, osteoporosis, if not first 5 days, then 2 days barrier
missed = 3 hours
>3 hours late: take missed pill, barrier for 48 hours
if 2 missed: take both and same, emergency if UPS
desogesterel = 12 hours
patch: 48 hours, barrier 7 days, emergency if <5 days of patch free or during
ring
IUS: 7 days after insertion if not 5 days first, 3-5 years
IUD: 10 years, childbirth 48 hours or.4 weeks after , not in menorrhagia
injection: 6-12 months for fertility to return, weight gain and ectopic
implant
never give contraception under 30
cocp: prevent ovulation
pop: thickens cervical
implant, injection, IUS: thickens cervical and prevent ovulation
stopping contraception
cocp, injection: continue after 50 years, switch to POP
injection can also be stopped after 2 years amenorrhoea
implant, POP, IUS continued
xondoms stopped 2 years <50, 1 year >50
Twin pregnancies
maternal: anaemia, GDM, pre-eclampsia, preterm birth, hyperemesis, DVT
foetal: TTTS
monochorionic: 12, 16 weeks -delivery every 2 weeks
dichorionic: 12, 20, to delivery every 4 weeks
after 24 weeks every 2 weeks to check IUGR - growth scans
monochorionic: 9 antenatal, at least 2 with consultant
dichorionic: 8, at least 2 with consultant
Twin trust support - SOB, abdomen largens, swollen
IPV
laser ablation of vascular anastomoses
hydrops fetalis
if TTTs, deliver by 37 weeks
can offer elective 36 (mono) and 37 (di)
mono - 36-37
di - 37-38
Normal physiological changes
Energy: more fat storage, less protein requirement, increased insulin sensitivity
Resp: no change in RR, inc minute ventilation, TV and breathlessness, red FRC
cardio: inc CO, SV, HR, more hypotensive and less peripheral resistance
endo: inc progesterone = reflux and constipation
kidney: inc aldosterone, GFR and reduced creatinine
haem: macrocytosis, dilutional anaemia, thrombocytopaenia, neutrophilia
Kidneys - increased urine output, pee more frequently - not only because of more urine from both foetus and mother but also foetus compressing the bladder and causing the feeling of fullness
If dysuria, haematuria, fever –> UTI
Skin - warm hands, palmar erythema
Advise woman to dress in layer
· Oesophageal sphincter not functioning –> reflux, heart burn
Lying down makes worse - upright after eating for 2 hours
If 3 meals difficult - break down into 6 snacks
Check OXBASE to see if medicines suitable in pregnancy
BUMPS - best use in medicine