Nutrition part 1 Flashcards
Fundamental goals of nutritional support
To meet the energy requirement for metabolic processes
To maintain a normal core body temperature
For tissue repair
Subjective global assessment
Clinical assessment of need for nutritional support
Presence of low serum albumin
Physical Examination
Weight change or unintentional weight loss
Presence of low serum albumin
Less than 3g/dl
Physical examination
Wasting of muscle mass Loose or flabby skin Presence of edema or ascites Glossitis Skin lesions
Weight loss of > 10% of IBW
Mild to moderate malnutrition
Weight loss of > 20% suggest
Severe malnutrition
Weight loss of > 30% is
Premorbid
Adequate indicator of malnutrition in absence of other causes of hypoalbuminemia
Albumin
Long half life of albumin
21 days
Albumin suggests adequate nutritional status
> 3.5 g/dl
Albumin suggest malnutrition
Albumin
Visceral proteins
Biochemical indicator of malnutrition
Visceral proteins
Rapid turnover proteins
Nitrogen balance
Indicator of the degree of illness rather than strictly nutritional status
Rapid turnover of proteins
Rapid turnover of proteins vary with
Hepatic metabolic response ( decreased synthesis )
Capillary leak response ( diluted serum levels )
Serum albumin half life
14-20 days
Serum pre albumin half life
2-4 days
Serum transferrin half life
8-10 days
Serum albumin in a stable, hydrated patient
Less than 3.5g/dL
Serum prealbumin corresponds to mild depletion
10-17
Serum prealbumin corresponds to moderate depeltion
5-10 mg/dl
Serum prealbumin corresponds to severe depletion
5mg/dl
Serum transferrin of
Less than 200mg/Dl
Sensitive indicator of malnutrition
Transferrin
How to calculate nitrogen balance?
Nitrogen loss minus nitrogen intake
How to calculate nitrogen intake
Sum of nitrogen delivered from enteral and parenteral feedings
Nitrogen losses are through
Urine
Fistula drainage
Diarrhea
How to estimate 24 hours urinary loss
UUN concentration x urine volume
How to calculate nitrogen loss
1.2 x 24 hours UUN in g/day plus 2
CHO stores are exhausted after a
24 hours fasting
Carbohydrates after 24hours fast
Liver glycogen is used first then muscle glycogen
In the first day of starvation, caloric needs are supplied by
Fat and protein
Protein is converted to glucose via
Hepatic gluconeogenesis
10days of starvation, the brain adapts to use of
Fats
The brain cannot use free fatty acids so it relies on
Ketoacids produce by liver
Adaptation to ketone usage has a
Protein sparing effect
Physiologic stress
Metabolic demand is dramatically incresed
Catabolic phase
Physiologic stress
Catabolic phase
Rise in the urinary excretion of nitrogen( mas malala sa starvation)
Protein depletion
Increased glucagon, glucocorticoids and catecholamines
Reduction of insulin
Physiologic stress
Shifting of catabolism to anabolism
Early anabolic phase
Early anabolic phase
Positive nitrogen balance
Weight gain
Muscular strength
Early anabolic phase mechanism
Babalik yung total amount ng nitrogen na nawala during catabolic phase, pero mas mabagal nga lang.