Nutrition And Biomolecules (DSA) Flashcards
The 3 sources of energy in our diet come in the form of carbs, proteins, and fats. Describe the energy content of each.
Carbs = 4 Calories/gram
Protein = 4 Calories/gram
Fats = 9 Calories/gram
What enzyme begins the digestion process in the mouth, and what fatty acids does it act on?
Lingual lipase - digests short and medium chain fatty acids
What digestive enzyme exists in the stomach and what types of fatty acids does it act on?
Gastric lipase - digests short and medium chain fatty acids
What digestive enzymes exist in the pancreas and digest TAGs?
Pancreatic lipase with colipase
What digestive enzyme exists in the pancreas and digests phospholipids?
Phospholipase
What digestive enzyme exists in the pancreas and digests cholesterol esters?
Cholesterol esterase
What are the 3 primary electrolytes required in the diet?
Sodium
Potassium
Chloride
What are the 5 primary minerals required in the diet?
Calcium Phosphorus Magnesium Iron Sulfur
What are the 4 trace minerals required in the diet?
Iodine
Selenium
Copper
Zinc
What are the 4 ultratrace minerals required in the diet?
Manganese
Fluoride
Chromium
Molybdenum
Name the vitamin and chemical groups transferred for the following cofactor:
Thiamine pyrophosphate
Thiamine (B1)
Transfers 2-carbon groups
Name the vitamin and chemical groups transferred for the following cofactor:
Pyridoxal phosphate
Pyridoxine (B6)
Transfers amino and carbonyl groups
Name the vitamin and chemical groups transferred for the following cofactor:
Methylcobalamin
Vitamin B12
Transfers acyl groups
Name the vitamin and chemical groups transferred for the following cofactor:
Coenzyme A
Pantothenic acid (B5)
Transfers acetyl groups
Name the vitamin and chemical groups transferred for the following cofactor:
Menaquinone
Vitamin K
Transfers carbonyl group and electrons
Name the vitamin and chemical groups transferred for the following cofactor:
Flavin Mononucleotide
Riboflavin (B2)
Transfers electrons
Name the vitamin and chemical groups transferred for the following cofactor:
NAD+ and NADP+
Niacin (B3)
Transfers electrons
Name the vitamin and chemical groups transferred for the following cofactor:
Lipoamide
Lipoic acid
Transfers electrons and acyl groups
Name the vitamin and chemical groups transferred for the following cofactor:
Biotin
Biotin
Transfers CO2
Name the vitamin and chemical groups transferred for the following cofactor:
Tetrahydrofolic acid
Folic acid (B9)
Transfers methyl and formyl groups
Name the vitamin and chemical groups transferred for the following cofactor:
Ascorbic acid
Vitamin C
Transfers electrons
Name the vitamin and chemical groups transferred for the following cofactor:
Coenzyme F420
Riboflavin (B2)
Transfers electrons
What vitamin deficiency is likely to lead to the following conditions and/or symptoms:
Cheilosis, angular stomatitis, dermatitis
Vitamin B2 (riboflavin)
What vitamin deficiency is likely to lead to the following conditions and/or symptoms:
Megaloblastic anemia, mental status changes, glossitis, pallor
Folate
What vitamin deficiency is likely to lead to the following conditions and/or symptoms:
Fatigue, depression, nausea, dermatitis, muscle pain
Biotin
[note that raw egg contains avidin, which binds biotin - rendering it unabsorbable]
What vitamin deficiency is likely to lead to the following conditions and/or symptoms:
Fatigue, sleep disturbance, impaired coordination
B5 (pantothenic acid)
[note that deficiency is rare]
What vitamin deficiency is likely to lead to the following conditions and/or symptoms:
Pernicious anemia, neurological disorders, pallor
B12 (cobalamin)
What vitamin deficiency is likely to lead to the following conditions and/or symptoms:
Nasolateral seborrhea, glossitis, peripheral neuropathy
B6 (pyridoxine)
What are the 4 primary lipid-soluble vitamins?
Retinol/retinoic acid (A)
Calcitriol (D)
Vitamin E
Vitamin K
[mnemonic = ADEK]
Which of the following is a water soluble vitamin?
A. Vitamin E
B. Vitamin B
C. Vitamin D
D. Vitamin K
B. Vitamin B
[Note that most vitamins, other than ADEK, are water-soluble]
What is the coenzyme form of Thiamine (B1)
Thiamine pyrophosphate
What 4 metabolic enzymes Thiamine (B1) involved in as a coenzyme?
PDH
Alpha-ketoglutarate dehydrogenase
Branched chain ketoacid dehydrogenase
Transketolase
What disease may lead to a deficiency in thiamine (B1), due to its interference with B1 absorption?
Alcoholism
What are the 4 potential clinical manifestations of thiamine (B1) deficiency?
Wernicke’s (ataxia, nystagmus, ophthalmoplegia)
Korsakoff’s (psychosis, confabulation)
Dry beriberi (muscle wasting, partial paralysis)
Wet beriberi (cardiac failure, peripheral edema)
What are the 4 primary sources of dietary carbohydrates?
Starch
Sucrose
Dietary fiber
Lactose
A starch is a nutritional reservoir of carbs in plants, describe its general structure
Polysaccharide of glucose
Sucrose is found in fruits and veggies, describe its general structure
Disaccharide of glucose and fructose
Lactose is a major dietary carb of animal origin, describe its general structure
Disaccharide of glucose and galactose
Lactose intolerance refers to the body’s inability to easily digest lactose due to a genetic deficiency of _________, with an age dependent decrease in production of the enzyme. This results in what clinical symptoms?
Lactase
Results in gas, belly pain, and bloating within 2 hours of consuming lactose
What is the difference in the fate of lactose in someone that is lactose tolerant vs. lactose intolerant?
Lactose tolerant individuals have lactase which breaks down the lactose into its monosaccharides Glucose and Galactose in the small intestine
Lactose intolerant individuals lack lactase, so bacterial fermentation takes place when lactose reaches the large intestine, producing gas and acids, leading to flatulence and abdominal pain
Name 4 monosaccharides
Glucose
Fructose
Galactose
Ribose
Name 3 disaccharides
Maltose
Lactose
Sucrose
What type of carbohydrate is a glycolipid or glycoprotein?
Oligosaccharides
What type of carbohydrate is glycogen, starch, or cellulose?
Polysaccharide
What are the 5 metabolically relevant modified monosaccharides?
Deoxyaldose (DNA) Acetylated amino sugars Acidic sugars Sugar esters Sugar alcohols
What is the clinical significance of sugar alcohols like mannitol, sorbitol, and xylitol?
They have fewer calories per gram, but are not as readily absorbed, so insulin sensitivity is reduced over time leading to the potential for uncontrolled diabetes complicated by cataracts and peripheral neuropathy
What type of bond forms between monosaccharides like glucose and fructose to form a disaccharide? (In this case sucrose)
Glycosidic bond
What is the difference between in amylose starch and an amylopectin starch?
They differ in their linkage
Amylose starch has an alpha (1-4) linkage
Amylopectin starch has an alpha (1-4) and an alpha (1-6)
What are the 3 essential fatty acids and why are they essential?
Omega 3: Linolenic acid
Omega 6: Linoleic acid and Arachidonic acid
[omega indicates location of double bond]
They are essential bc they must be obtained from the diet; our bodies cannot form double bonds in those locations
What are the pathological consequences of deficiencies in your lipid soluble vitamins?
A - xerophthalmia (night blindness)
D - rickets
E - muscular dystrophy, neurologic
K - defective coagulation, anemia
_________ are synthesized from acetyl coA via intermediate IPP. Condensation of IPP results in ________, vitamins, and coenzyme Q
Isoprenoids
Steroids
What is the most important steroid due to being a component of cell membranes, precursor in reactions, and component of bile?
Cholesterol
Cholesterol is a precursor to which of the following?
A. Fat-soluble vitamin D
B. Water-soluble vitamin D
C. Fat-soluble vitamin B
D. Water-soluble vitamin B
A. Fat-soluble vitamin D
Which amino acids are essential?
WH MILK FVT (sometimes R)
[mnemonic WHole MILK not my FaVoRiTe]
Which amino acids are polar and uncharged?
NCQSTY
Which amino acids are polar and negatively charged?
Aspartic acid (D) Glutamic acid (E)
Which amino acids are polar and positively charged?
Arg (R)
His (H)
Lys (K)
Which of the amino acids are nonpolar?
Alanine (A) Glycine (G) Isoleucine (I) Leucine (L) Methionine (M) Phenylalanine (F) Proline (P) Tryptophan (W) Valine (V)
What are the 3 primary functions of proteins in the body?
Fuel: amino acids generate ATP in TCA
Structural: key components in connective tissue
Activity: enzymes, cell signaling, transport