Nutrient digestion and absorption Flashcards

1
Q

What are the 3 monosaccharides ?

A

Glucose
Galactose
Fructose

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2
Q

Where are monosaccharides absorbed ?

A

Small intestine

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3
Q

What are disaccharides ?

A

2 monosaccharides linked by glycosidic bond

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4
Q

What breaks down disaccharides into monomers in small intestine ?

A

Brush border enzymes

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5
Q

What does lactase do ?

A

Breaks down lactose into glucose and galactose

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6
Q

What does sucrase do ?

A

Breaks down sucrose into glucose and fructose

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7
Q

What does maltase do ?

A

Breaks down maltose into 2 glucose

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8
Q

What are 3 polysaccharides ?

A

Starch- plants
Cellulose- plant cell wall
Glycogen- animal storage form of glucose

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9
Q

In glycogen what are glucose monomers linked by ?

A

Alpha-1,4 glycosidic bonds

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10
Q

What are proteins ?

A

Polymers of amino acids linked by peptide bonds

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11
Q

What do proteins undergo ?

A

Post-translational modification

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12
Q

What are small proteins called ?

A

Peptides

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13
Q

What enzymes breakdown proteins and peptides ?

A

Proteases and peptidases

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14
Q

What is the breakdown products of proteins and peptides ?

A

Amino acids

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15
Q

In what form is fat digested ?

A

Triacylglycerol

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16
Q

What enzymes digest fats ?

A

Pancreatic lipases

17
Q

Are lipases water soluble ?

18
Q

What is triacylglycerol broken down into ?

A

Monoglyceride + 2FAs

19
Q

What is emulsification ?

A

Dividing large liquid droplets into small droplets

20
Q

What does emulsification require ?

A

Mechanical disruption- smooth muscle contraction grinds and mixes lumenal contents
Emulsifying agents- bile salts + phospholipid secretion in bile

21
Q

How is absorption enhanced ?

A

Formation of micelles

22
Q

What are micelles ?

A

Bile salt + monoglyceride + FA + phospholipid

23
Q

What is the product of micelle breakdown ?

A

Release of small amounts of free fatty acids and monoglycerides into solution that diffuse across plasma membrane of absorbing cells

24
Q

Where do FAs and monoglycerides enter after entering epithelial cells ?

A

sER- where they are reformed into triacylglycerols

25
How are triacyclglycerols transported ?
In vesicles formed from sER and processed through golgi apparatus and exocytosed into extracellular fluid at serosal membrane
26
What are chylomicrons ?
Extracellular fat droplets
27
Where do chylomicrons pass into ?
Lacteals between endothelial cells - cannot pass through capillary membrane
28
What are the fat soluble vitamins ?
A D E K Absorbed same as fat
29
What are the water soluble vitamins ?
B group C Folic acid
30
How are water soluble vitamins absorbed ?
Bind to intrinsic factor in stomach to form complex which is absorbed via specific transport mechanism in distal ileum
31
How is iron absorbed ?
Iron transport across brush border membrane (via DMT1) into duodenal enterocytes Iron ions incorporated into ferritin (protein-iron complex-> intracellular iron store) Unbound iron transported across serosal membrane-> blood
32
What does iron in the blood bind to ?
Transferrin
33
What is hyperaemia ?
Increased ferratin levels-> more iron to enterocytes
34
What is aneamia ?
Decreased ferratin levels-> more iron released to blood