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Pharmacology > Nurs 605 Module 2 > Flashcards

Nurs 605 Module 2 Flashcards

1
Q

What is acute bronchitis?

A
  • inflammation of the bronchi

- cough <3 weeks

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2
Q

What are the common pathogens of acute bronchitis?

A

> 90% is viral

<5% - c. pneumoniae, mycoplasma pneumoniae, bordatella pertussis

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3
Q

What are the clinical manifestations of acute bronchitis?

A 
cough <3 weeks
no tachycardia
no dyspnea
no fever
localized or normal chest sounds
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4
Q

What are the nonpharmaceutical recommendations for acute bronchitis?

A

self limiting
watchful waiting
hydration, natural health products ie) honey
return to clinic if worsens or no improvement after 2-3 weeks

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5
Q

What are the pharmaceutical recommendations for acute bronchitis?

A

analgesics
cough suppressants
bronchodilators ie) ventolin
opiods cough syrup

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6
Q

What is acute otitis media (AOM)?

A

middle ear infection

common in children due to shorter eustachian tubes

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7
Q

What are the risk factors for AOM?

A 
age
children in smaller households
children in daycare
second hand smoke exposure 
immunocompromised 
indigenous children 
orofacial abnormalities
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8
Q

Do we need to treat for AOM and why?

A

mostly self limiting
often don’t need to treat
watchful waiting for 24-48 hours, no improvement or worsening, consider abx

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9
Q

What are the clinical manifestations of AOM?

A 
onset of acute ear pain
otalgia (pulling or touching of the ear)
fever
irritabillity
middle ear inflammation
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10
Q

Describe middle ear inflammation

A

TM bulging
dull, no light refraction
may be filled with fluid (potentially grey colour)

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11
Q

When would you advise watchful waiting for a child with AOM?

A

reliable follow up
>6 months of age
non severe symptoms for 72 hours (no temperature)

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12
Q

What are the common pathogens of AOM?

A

S. pneumoniae (31-49%; most common)
H. Influenzae
M. Catarhalis

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13
Q

What is the systemic standard treatment for AOM?

A

Amoxicillin 40mg/kg TID x 5 days OR

Amoxicillin 90mg/kd BID/TID x 5 days

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14
Q

What is acne vulgaris?

A

most common skin disorder

often appears at puberty but can present at any stage in life

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15
Q

Describe the topical treatment options for acne

A

topical benzoyl peroxide or topical retinoids or topical antibiotics or a combination of the above

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16
Q

Describe the adverse reactions to topical benzoyl peroxide

A

relatively safe
first line
larger doses or concentrations can bleach clothing

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17
Q

What is the recommended topical benzoyl peroxide concentration and at what concentration are topical benzoyl peroxides prescribed?

A

recommended for acne 2.5%-10% concentration

>5% concentration is via prescription only

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18
Q

What is the most commonly used topical antibiotic?

A

Clindamycin topical ointment

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19
Q

Write a rx for topical benzoyl peroxide

A

Benzoyl peroxide 5% cream apply to affected areas BID as needed

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20
Q

What is the recommended systemic treatment for acne?

A

tetracyclines

reserve macrolides for more severe cases or if tetracyclines don’t work

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21
Q

Name the gram + staphylococci species

A

staph aureus**
staph epidermis**
staph saprophyticus

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22
Q

Name the gram + streptococcus species

A 
strep progenies/group A**
group B strep
group C strep
strep viridian's
strep pneumonia**
enterococcus
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23
Q

Name the gram + bacilli species

A

listeria monocytogenes
bacillus anthrax
clostridium

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24
Q

Name the gram - cocci species

A

neisseria gonorrhoea
n. meningitis
moraxella catarrhalis **

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25
Q

Name the gram - bacilli species

A

h. influenza**
legionella pneumophila
bactericides fragilis

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26
Q

Name some enterobacteraciae

A

e. coli
klebsiella pneumoniae
proteus vulgaris

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27
Q

Name psuedomonads

A

pseudomonas aeurginosa

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28
Q

What is osteomyelitis?

A

infection of the bone

usually because of infection of soft tissue gets into the bone

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29
Q

What are the causes of osteomyelitis?

A

soft tissue injury
IVDU
traumatic injury such as bite wounds or fractures

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30
Q

What are the clinical manifestations of osteomyelitis?

A

history of risk i.e.) soft tissue injury etc.
ongoing and worsening MSK pain
fever

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31
Q

What are the different types of antimicrobials

A 
antivirals
antibiotics
antifungals
antiprotozoals
anthelminics-parasites
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32
Q

What is the difference between gram + and gram - bacteria?

A

gram +: thicker petidoglycan outer layer, stains blue; vulnerable to penicillins
gram -“ thinner polysaccaride outer layer; resistant to penicillin (blocks the entry of abx)

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33
Q

Bacteriostatic vs. bacteriocidal

A

bacteriostatic-inhibits growth of bacteria
bacteriocidal-destroys and kills the organisms
certain pathogens and infections require bactericidal effects such as meningitis

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34
Q

Describe the difference between time dependent killing and concentration dependent killing

A

abx classes fall under time dependent or concentration dependent killing
certain abx require more frequent dosing in order to have bacterialcidal effects (time dependent)
other abx require less frequent dosing but higher concentrations in order to achieve bacteriocidal effects

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35
Q

What are the 4 targeted mechanisms of action of antibiotics?

A
  1. inhibits cell wall synthesis
  2. inhibits protein synthesis
  3. inhibits nucleic acid synthesis
  4. inhibits cell membrane function
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36
Q

How do beta lactam antibiotics inhibit cell wall synthesis?

A

beta lactam ring

inhibits cell wall synthesis by hydrolyzing the cell wall of bacteria

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37
Q

How do antibiotics act on the cell wall on pathogens?

A

antibiotics effectly kill bacteria by inhibiting the synthesis of the cell wall by binding itself to the proteins that make up the cell wall-bacteriocidal

38
Q

Describe beta lactam resistance

A

bacteria synthesizes beta lactamase which is an enzyme that destroys the beta lactam ring in the abx thus making it useless

39
Q

What are common beta lactam abx?

A

penicillins: penicillin, ampicillin, amoxicillin
cephalosporins: cefazolin, cefixime, ceftriaxone
carbapenems: meropenum

40
Q

How do abx inhibit protein synthesis?

A

abx work to inhibit protein synthesis by binding to ribosomal subunits in bacteria to prevent complex protein cascades=bacteriostatic and prevents growth of bacteria

41
Q

What types of abx inhibit protein synthesis of bacteria?

A

aminoglycosides
tetracyclines
macrolides

42
Q

What are some considerations of prescribing aminoglycosides?

A

can be nephrotoxic, ototoxic and can cause visceral toxicity
must dose according to patients GFR
distributes well into lean body tissue

43
Q

What are some common aminoglycosides?

A

gentamycin

tobramycin

44
Q

Tetracyclines are used for what conditions?

A

CAP

acne, STIs, lyme disease

45
Q

What are some considerations when precscribing tetracyclines?

A

can cause gastritis when taken incorrectly
no dairy products
can increase photosensitivity
no pregnant women and children under 8 years of age

46
Q

Describe considerations when using macrolides

A 
macrolides should be reserved for atypical bacteria and gram pos. bacteria
or beta lactam allergies
increasing resistance to macrolides 
do not prescribe for CAP 
poor activity against enterococci
47
Q

What are common tetracyclines?

A

doxycylne

minocycline

48
Q

What are common macrolides

A

azithromycin

erythromycin

49
Q

What is an adverse side effect of clindamycin that should be reported immediately?

A

can cause pseudomonas colitis which is severe diarrhea-should be reported

50
Q

How do abx inhibit nucleic acid synthesis?

A

disrupts bacterial RNA/DNA and precursor synthesis causing cell death

51
Q

What classes of antibiotics are considered those that inhibit nucleic acid synthesis?

A

nitromiazoles-flagyl
fluoroquinolones
sulphanomides

52
Q

Describe the use of metroniazole and what considerations should you have for the patient?

A

metroniazole or flagyl is a nucleic acid synthesis inhibitor
used against anerobic bacterias such as H. pylori, amoebas
those taking flagyl should not have alcohol as it can cause excessive vomiting

53
Q

What is a common fluoroquinolone?

A

ciprofloxacin

54
Q

Describe the use of ciprofloxacin, what class of abx it is in and any special considerations with this abx.

A

used for gram negative bacteria such as e.coli, H. infleunza and pseudomona aeuringinosa
is an older generation flouroquinolone

55
Q

What are the respiratory fluroquinaoles and what considerations must be taken with them?

A

moxafloxacin and levofloxacin
reserved for 3rd line treatment only
improved gram + coverage and gram - coverage
won’t cover pseudomonas

56
Q

What are the sulphonamides and what are considersations when using using this abx/

A

sulpha drugs
usually used in conjunction wth other medications such as trimethoprim (TMP/SMX) to increase coverage
gram +/- coverage, some protozoa coverage
increasing resistance
medication interactions: wafarin, phenytoin, methotrexate

57
Q

What are some considerations of choosing an antimicrobial?

A 
treatment actually needed?
start small and narrow
cultures and sensitivities
cost
toxicity
adverse events and cost? 
allergies?
58
Q

What is the treatment for dog, cat, and human bites?

A

Amoxicillin/Clavulin 875mg PO BID x 7-10 days

59
Q

A patient has just suffered a cat bite and has a beta lactam allergy; what would be the choice of treatment?

A

Doxycycline 100mg PO BID x 7-10 days

60
Q

A patient presents with phargyngitis, no cough, tonsillar exudate and a fever of 39.0. What would your differential diagnosis and treatment?

A

group A hemolytic strep throat
cultures and sensitivities
treat with penicillin 600mg BID PO x 10 days
children: pencillin 20mg/kig BID PO x 10 days

61
Q

When would you advise treatment for acute sinusitis and what would be your drug of choice?

A

watchful waiting, generally spontaneously resolved in 7-10 days
viral 98% but may turn bacterial complications
amoxicillin 500mg-1000mg TID PO x 5-7 days is drug of choice

62
Q

In a child that has AOM, what doses of acetaminophen or ibuprofen can you provide?

A

acetaminophen 10-15mg/kg/dose q 4 hours (max 75mg/kg/day)

ibuprofen 10mg/kg/dose q 6-8 hours (max 40mg/kg/day)

63
Q

If the child has a perforated tympanic membrane from AOM; what would be the drug of choice?

A

Amoxicillin 45mg/kg/day TID PO x 10 days AND amoxi-clav (7:1) 45mg/kg/day TID x 10 days

64
Q

A child presents with AOM and purulent conjunctivitis; what antibiotic treatment would you provide?

A

Amoxicillin clavulin (7:1) 45mg/kg BID x 5 days

65
Q

A child that has AOM was started on abx but has not seen any improvement, what would be your next steps?

A

add amoxi-clav (7:1) 45mg/kg/kg BID x 10 days and amoxiicillin 45mg/kg/day BID x 10 days
if already given at high dose, give amoxi-clav only

66
Q

What would you give a child with AOM that has a beta lactam allergy?

A

decide whether it’s a real allergy because options are limited
can try cefixime and clindamycin (must be together)
TMP-SMX
doxycycline if >8 years
may need to consult

67
Q

What is acute sinusitis?

A

inflammation and infection of the sinuses

68
Q

Do you need to treat for acute sinusitis?

A

not usually as most are viral in nature

can proceed to bacterial infection

69
Q

What would you suggest to someone that is having acute sinusitis?

A

watchful waiting
rinses, analgesics
return to clinic if worsens in 7 days

70
Q

What would be the systemic treatment for acute sinusitis?

A

amoxicillin 500mg TID PO x 5-7 days

71
Q

What are the common pathogens of acute sinusitis?

A

s. pnuemonia
h. influenzae
m. catarrhalis

72
Q

What would you provide to someone that has a beta lactam allergy who presents with worsening acute sinusitis

A

doxycycline 100mg BID x 7 days

73
Q

What are the systemic treatments for acute exacerbation of bronchitis?

A

amoxicillin 1000mg TID x 5-7 days or doxycycline 200mg stat, then 100mg BID x5-7 days TMP/SMX 1 DS tab BID

74
Q

First line systemic treatment for acute exacernbation of acute bronchitis has failed, what is the next abx option?

A

amoxi/clav 875mg BID x 5-10 days or levofloxacin 750mg daily x 5 days

75
Q

What is community aquired pneumonia?

A

CAP is an acute lung infection
can be treated in or out of hospital
generally better survival rates when treated as outpatient
older adults are at increased risk of mortality

76
Q

What are the common pathogens that cause CAP?

A

s. pnuemoniae
h. influenzae
atypicals: mycoplasma pneumonia, chlamydia pneumonia

77
Q

What are risk factors that can cause CAP?

A

COPD, hospitalization, smoking, alcoholism, lung cancern

78
Q

What is first line treatment for CAP?

A

doxycycline 200mg stat, then 100mg BID PO x 5-7 days or +/-amoxicillin 1000mg TID x 5-7 days

79
Q

What would your drug of choice be for an individual who has COPD but presents with CAP?

A

amoxicilin 1000mg TID x 5-7 days or amoxi/clav 875mg BID x 5-7 days PLUS doxycycline 200mg stat, then 100mg BID x 5-7 days

80
Q

A patient presents with unresolved CAP despite treatment of doxycyline; what would be the treatment of choice?

A

try what the patient hasn’t tried before

amoxicillin 1000mg TID x 5-7 days or amoxi/clav 875mg BID x 5-7 days PLUS TMP/SMX 1 DS tab BID x 7 days

81
Q

Patient presents with CAP, has tried amoxicillin/doxy combo with no effect, what is the treatment for this failure?

A

can try respiratory abx

levofloxacin 750mg PO daily x 7 days

82
Q

What is cystitis and its clinical manifestations?

A 
"bladder infection"
increased urinary frequency
increased urinary urgency
dysuria
suprapubic pain
83
Q

You find leukocytes in urine but the patient is asymptomatic; what do you call this condition and would you treat it?

A

asymptomatic bactereuremia

no do not treat unless symptomatic

84
Q

What is pyleonephritis and its clinical manifestations?

A 
kidney infection; infection of the upper urinary tract 
flank pain
nausea/vomiting
malaise
fever
85
Q

What is the first line treatment for women with cystitis?

A

nitrofurantoin 100mg BID x 5 days

fosfomycin 3g x 1 dose

86
Q

What are alternative treatments for women with cystitis (aside from macrobid and fosfomycin)?

A

TMP/SMX 1 tab x 7 days
cefixime 400mg OD x 7 days
ciprofloxacin 250mg BID
increasing resistance in cipro and TMP/SMX

87
Q

A woman presents with a recurrent UTI, it has been < 1 month since her last UTI; what are their treatment options?

A 
same organism? same drug
different organism? treat as if pyelonephritis
cefixime 400mg OD
cipro 500mg BID
TMP/SMX 1 DS BID 
amox/cav 875 mg x 10 days
88
Q

Why would you not use nitrofurantoin in someone who has pyelonephritis?

A

macrobid does not penetrate well into the renal tissues therefore not effective

89
Q

A pregnant female presents with cystitis; what would be your drug of choice?

A

macrobid 100mg BID x 7 days (avoid near term)
fosfomycin 3g x 1 dose
cefixime 400mg OD x 7 days

90
Q

A male presents with cystitis; what would be your first choice of treatment?

A

cefixime 400mg OD x 7 days
ciprofloxacin 500mg BID x 7 days
amoxi/clav 875mg BID x 7 days
TMP/SMX 1 DS tab x 7 days

Pharmacology (13 decks)

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