Nucleotides

Question 1

Def of purine

Answer 1

Two ring system - 6 member and 5 member, share 2

Question 2

Pyrimidine def

Answer 2

6 member ring

Question 3

Dif between Ribose and Deoxyribose

Answer 3

OH (ribose) and H (deoxyribose) at 2’ carbon

Question 4

Nucleotide def

Answer 4

A nucleoside with a phosphate added at the 5’ C, through ester linkage. Added P through phosphoanhydride bond

Question 5

Base, nucleotide, nucleoside

Answer 5

Question 6

Base, nucleoside, nucleotide

Answer 6

Question 7

Base

Answer 7

Question 8

base

Answer 8

Question 9

Base

Answer 9

Question 10

Enzyme that activates ribose - 5’ - phosphate and the final product

Answer 10

Enzyme: ribose phosphate pyrophosphate kinase

Product: Phosphoribosyl pyrophosphate (pRpp)

Question 11

Commited step of purine synthesis

Answer 11

Formation of 5’ - phosphoribosyl amine

Question 12

The formyl groups used to make the purine ring are derived from a precursor derived from which vitamin?

Answer 12

Folic acid

Question 13

Total phosphates needed for AMP, GMP production

Answer 13

AMP: 8

GMP: 9

Question 14

Negative regulators of ribose phosphate pyrophosphate kinase

Answer 14

AMP and GMP

Question 15

Feedback

Answer 15

Question 16

human disease caused by a deficiency of HGPRT and symptoms

Answer 16

Lesch Nyhan (LN) syndrome

Elevated Uric acid, gout-like symptoms