Nucleoside Reverse Transcriptase Inhibitors

Question 1

Zidovudine

Answer 1

Thymidine analog

Bone marrow suppression

Question 2

Emtricitabine

Answer 2

Cytidine analog

Question 3

Abacavir

Answer 3

Guanosine analog

Fever, rash

Question 4

Didanosine

Answer 4

Guanosine analog

Pancreatitis

Question 5

Stavudine

Answer 5

Thymidine analog

Lipodystrophy

Question 6

Lamivudine (3TC)

Answer 6

Cytidine analog

Least toxic; Hep B

Question 7

Tenofovir

Answer 7

Adenosine analog

GI upset

Question 8

NRTIs

Answer 8

Zidovudine
Lamivudine
Tenofovir
Didanosine

Question 9

MOA of NRTIs

Answer 9

Nucleoside analog but lacks 3’-OH. Results in chain termination after incorporation by reverse transcriptase.

Question 10

Zidovudine (AZT) is an analog of

Answer 10

Thymidine

Question 11

Tenofovir is different from other NRTIs b/c

Answer 11

it is a nucleotide (contains 1 phosphate)

Question 12

Tenofovir is an analog of

Answer 12

adenosine

Question 13

S/E of NRTIs

Answer 13

Mitochondrial toxicity
Mitochondrial DNA polymerase gamma enzyme inhibited 
Loss of Mitochondria
Peripheral neuropathy (pain/paresthesia)
Myopathy
Pancreatitis
Lactic Acidosis

Question 14

Zidovudine (AZT) S/E

Answer 14

Bone marrow suppression

Give with G-CSF or Epo

Question 15

Which NRTIs can be given to prevent maternal-fetal transmission of HIV?

Answer 15

Zidovudine (AZT)