Nucleoside antifungals

Question 1

Brand-name for flucytosine

Answer 1

Ancobon

Question 2

Inhibits fungal protein synthesis by replacing uracil with 5-flururacil in fungal RNA

Answer 2

flucytosine

Question 3

Brand name for amphotericin B

Answer 3

Fungizone

Question 4

It was purified fro the fermentation beer of a soil culture of the actinomycete Streptomyces nodosus

Answer 4

Amphotericin B

Question 5

Believe to interact with membrane sterols

Answer 5

Amphotericin B

Question 6

Brand name for nystatin

Answer 6

mycostatin

Question 7

From strain of actinomycete Streptomyces noursei

Answer 7

nystatin

Question 8

What is the aglycone portion of nystatin called

Answer 8

nystatinolide

Question 9

Tx of local and gastrointestinal monilial infections caused by candidiasis spp

Answer 9

nystatin

Also for cutanuoes and mucocutaneous candidiasis

Question 10

Brand name for natamycin

Answer 10

Primacin, natacyn

Question 11

Obtained from s. natalensis

Answer 11

natamycin

Question 12

Structures consist of a 26-membered lactone ring containing a tetraene chromophore

Answer 12

natamycin

Question 13

Antibiotic obtained from the fungus of peniccilym griseofulvum

Answer 13

Griseofulvin - grisovin

Question 14

Isolated originally as a curling factor in plants

Answer 14

griseofulvin

Question 15

More potent than naftitine

Answer 15

Terbinafine HCl

Question 16

Oral activity against onchomycosis

Answer 16

Terbinafine HCl

Question 17

MOA of terbinafine

Answer 17

Inhibition of squalene epoxidase

Question 18

Topical treatmet for ringworm athletes foot and jock itch

Answer 18

Naftitine hcl

Question 19

Fungicidal against dermatophytes

Answer 19

tolnaftate

Question 20

Topically tx for tinea infections and candidiasis

Answer 20

clotrimazole

Question 21

More effective against torulopsis glabrata

Answer 21

tioconazole

Question 22

Miconazole brand name

Answer 22

Daktarin
- azole antifungals