Nuclear Hormone Receptors

Question 1

What is the mechanism of action of a steroid

Answer 1

Lipophilic ligand permeates the plasma membrane and binds receptor
Receptor undergoes ligand-dependent release from cytoplasmic sequestration
Ligand end receptor dimerises and trans locates into the nucleus

Question 2

What is the mechanism of action of retinoid acid type receptors?

Answer 2

Receptor dimer is stably bound to DNA in an inactive state
Lipophilic ligand permeates the plasma membrane and nucleus
OR
Ligand precursor is converted to ligand intracellular lay

Question 3

What is the mechanism of action of nuclear orphan receptors

Answer 3

Receptor monomer is stably bound to DNA in an inactive state
Ligand permeates the plasma membrane and nucleus
OR
Other post translational modification of receptor results in its activation