NTK Flashcards
Murmurs needing further work up
Systolic III or greater Any diastolic
Rumbling diastolic with opening snap = Tx?
Mitral stenosis Balloon valvuloplasty Surgery later
Pathology of aortic insufficiency
Infection Infarction Aortic Dissection
Acute aortic insufficiency =
Cardio gen I shock Flash pulmonary edema
Chronic aortic insufficiency
CHF Chest pain
Rumbling diastolic murmur right sternal border second intercostal space =
Aortic insufficiency
Pathogenesis of aortic stenosis
Atherosclerosis Older men
Crescendo, descrescendo systolic murmur at right sternal border 2nd ic space
Aortic stenosis
Systolic, high pitched, HOLOSYSTOLIC murmur at the apex of the heart
Mitral insufficiency (regurgitation)
Two murmurs More blood - less murmur
HCM and MVP
Common meds leading to exposing G6PD
Dapsone TMP-SMX Nitrofurantoin
When to check G6PD level?
6-8 weeks after an attack
Coombs positive for IgG = warm autoimmune hemolytic anemia Conditions?
Autoimmune diseases Cancer
Diagnosis of PNH? Tx?
Flow cytometry Eculizumab
Female pt Elevated T4 Cold Thyroid uptake scan Next step?
Sestamibi of Ovaries Struma ovarii
Thyroid Storm Tx steps
Cool down - IVF, Cold blankets Propranolol PTU/Methimazole Steroids
Radioactive iodine better for (3)
Multinodular goiter Toxic adenoma Struma ovarii
Anterior Pituitary secretes
ACTH TSH GH FSH/LH
Prolactinomas Macroadenoma more likely in? Micro?
Men get macro Women get micro
Prolactinoma treatment
Dopamine agonists CABERGOLINE, bromocriptine
What releasing hormone can cause elevations of prolactin?
TRH
Acromegaly work up steps
ILGF-1 Glucose suppression test + equals failed to suppress MRI SURGERY
Pyramid of importance of pituitary hormones (In descending order)
ACTH TSH GH LH/FSH
Three MCC of Chronic Hypopituitary
Autoimmune Deposition disease - sarcoidosis, amyloidosis Tumor
Lung cancer with SIADH
Small cell
Treatment for nephrogenic DI when all else fails
Gentle dieresis w/ HCTZ +- Ameloride
Remnants of nuclear material in RBC’s
Howell Jolly Bodies Indicates splenectomy or functional hyposplenism
Hemoglobin precipitates in RBC’s
Heinz bodies
Dofetilide Type of med? Side effects?
Class III antiarrhythmic for management of atrial arrhythmias dose dependent QT prolongation
Horizontal nystagmus, cerebellar ataxia, confusion Toxicity?
Phenytoin
Tremor, hyperreflexia, ataxia, seizures Toxicity?
Lithium
Nonpregnant patients with syphilis and anaphylactic penicillin allergy Tx?
Doxycycline
Steps for lead screening (If positive risk factors)
Capillary lead >5 Confirm with Venous lead Level 45-69 = DMSA Level >70 = Dimercaprol + EDTA
Abnormal eosin-5-maleimide binding test =
Hereditary spherocytosis
Congenital Rubella triad
Cataracts/glaucoma Sensorineural hearing loss Congenital heart disease
Key difference between bulimia and anorexia
Weight Bulimia = normal weight Anorexia = low weight
MCC of spontaneous lobar hemorrhage in adults over 60 Most common lobes involved?
Cerebral amyloid angiopathy Parietal and Occipital
MCC intracranial hemorrhage in children
AVM
Ischemic stroke appears _______ on CT
Hypodense on CT
Signs of posterior urethral injury Diagnostic imaging study of choice
Blood at meatus High riding prostate Perineal or scrotal hematoma Retrograde urethrogram
Trimethoprim mechanism of hyperkalemia
Blocks Na channels in collecting tubule (Similar to amiloride)
Galactosemia quartet Deficient enzyme
FTT Bilateral cataracts Jaundice Hypoglycemia galactose-1-phosphate Uridyl transferase
Treatment of warm Autoimmune Hemolytic anemia
High dose glucocorticoids first
Alcoholic dilated cardiomyopathy Tx?
Abstinence Return to function or normalization is possible
Trial of labor contraindicated for what two prior surgeries?
Vertical c section Abdominal myomectomy with UTERINE CAVITY ENTRY
Most common transfusion reaction is?
Febrile nonhemolytic
Fever and chills within 1-6 hours of transfusion = D/t?
Febrile nonhemolytic reaction Cytokines accumulated during blood storage
Fever, flank pain, hemoglobinuria, renal failure and DIC within an hour of transfusion = Causes by?
Acute Hemolytic ABO incompatibility Positive direct Coombs , Pink plasma
Mild fever and hemolytic anemia 2-10 days after transfusion= Due to?
Anamnestic antibody response Positive direct Coombs, positive new antibody screen
Anaphylactic transfusion reaction is due to?
IgA deficiency Anti-IgA antibodies
Respiratory distress, noncardiogenic pulmonary edema within 6 hours of transfusion =
TRALI Donor anti-leukocyte antibodies
Risk factor most common for TAA and AAA
Atherosclerosis
Risk factor most common for aortic dissection
Hypertension
Stable SVT tx Unstable?
Adenosine Shock
Stable Afib tx Unstable
Rate control - BB Shock
Stable Torsades tx Unstable
Magnesium Shock
Stable Vtach tx Unstable?
Amiodarone Shock
MCC of prolonged or arrested second stage
Fetal malposition
Major side effect of Hydroxychloroquine
Retinopathy Regular eye exams
Vast majority medulloblastomas occur where?
Cerebellar vermis
Most common hemispheric tumors in children
Low grade Astrocytomas
What type of tumor is associated with Parinaud syndrome?
Pineal gland tumor
Observation and analgesics is appropriate for acute otitis media under what conditions?
Age over 2 years Normal immune system Symptoms mild and unilateral
Secretory diarrhea vs Osmotic diarrhea Stool osmotic gap
Low in secretory Elevated in osmotic
Amantadine side effects
Livedo reticularis Ankle edema
Two tests for Chronic Granulomatous Disease
Nitroblue tetrazolium Dihydrorhodamine
Which alcohol ingestion is not associated with high anion gap or acidosis
Isopropyl alcohol Methanol, ethylene glycol, and alcohol ketoacidosis are all associated with High gap acidosis
Mechanism of decreased vital capacity in COPD
Air trapping during expiration
Intranuclear and intracytoplasmic inclusions = Intranuclear only =
CMV HSV
Most common complication of asymptomatic bacteriuria in pregnant women Why?
Acute pyelonephritis Progesterone of pregnancy relaxes smooth muscle and causes ureteral dilatation Also associated with pre term labor and low birth weight
Increased risk of vibrio infection with what underlying disease?
Liver disease (Like hemochromatosis, cirrhosis, hepatitis)
Tachypnea beginning shortly after birth but resolving by day 2 Imaging findings
Transient tachypnea of newborn Bilateral perihilar linear streaking
Tachypnea and severe cyanosis in term or post term infant
Persistent pulmonary hypertension
Patients with CPPD should be evaluated for what underlying causes?
Hyperparathyroid Hypothyroid HEMOCHROMATOSIS (especially with family history of diabetes)
Chrondrocalcinosis is seen in?
CPPD NOT RA OR GOUT
Hookworms 2 Disease Tx?
Ancylostoma caninum and braziliense Cutaneous Larval migrans Ivermectin
Work up of chronic cough that worsens at night and doesn’t improve with anti histamines
PFT’s Or Trial of corticosteroids
Young person Unsteady gait and weakness of lower limbs Decreased vibratory and position sense High plantar arches MRI shows atrophy of spinal cord, minimal cerebellar atrophy T wave inversions on ekg
Friedrichs Ataxia Trinucleotide repeat disorder GAA
aortic regurgitation best heard in right sternal border = Combined with 2:1 AV block and IVDA
Aortic root disease Perivalvular abscess
Trichomoniasis Treat patient and partner or just patient?
Patient and partner
Nocturia on an AA patient
Hyposthenuria Related to Sickle Cell trait - family history
Elderly Bone pain Hypercalcemia Renal insufficiency Granular casts on urinalysis
Multiple myeloma Monoclonal protein production
Scotch tape tests positive Organism? TreatMent?
Enterobius vermicularis Albendazole or pyrantel pamoate For patient and all household contacts
Agents causing idiosyncratic liver reactions
Isoniazid Chlorpromazine Halothane Antiretrovirals
Raised lesions, <1cm Dimples in the center when edges are pinched Dx
Dermatofibroma Buttonhole sign
Predominant leukemia in children 2-10 Diagnostic?
ALL Presence of >25% lymphoblasts in the marrow PAS positive aggregates TdT positive