NSG 100 Exam 3 Flashcards
The patient is receiving two different drugs. At current dosages and dosage forms, both drugs have the same concentration of active ingredients. Which term is used to identify this principle?
a. Bioequivalent
b. Synergistic
c. Prodrugs
d. Steady-state
a. Bioequivalent
Rationale: Two drugs absorbed into the circulation in the same amount (in specific dosage forms) have the same bioavailability; thus, they are bioequivalent.
A drug’s steady state is the physiologic state in which the amount of drug removed via elimination is equal to the amount of drug absorbed from each dose.
The term synergistic refers to two drugs, given together, with a resulting effect that is greater than the sum of the effects of each drug given alone.
A prodrug is an inactive drug dosage form that is converted to an active metabolite by various biochemical reactions once it is inside the body.
When given an intravenous medication, the patient says to the nurse, “I usually take pills. Why does this medication have to be given in the arm?” What is the nurse’s best answer?
a. “The medication will cause fewer adverse effects when given intravenously.”
b. “The intravenous medication will have delayed absorption into the body’s tissues.”
c. “The action of the medication will begin sooner when given intravenously.”
d. “There is a lower chance of allergic reactions when drugs are given intravenously.”
c. “The action of the medication will begin sooner when given intravenously.”
Rationale: An intravenous (IV) injection provides the fastest route of absorption. The IV route does not affect the number of adverse effects, nor does it cause delayed tissue absorption (it results in faster absorption). The IV route does not affect the number of allergic reactions.
The nurse is administering parenteral drugs. Which statement is true regarding parenteral drugs?
a. Parenteral drugs bypass the first-pass effect.
b. Absorption of parenteral drugs is affected by reduced blood flow to the stomach.
c. Absorption of parenteral drugs is faster when the stomach is empty.
d. Parenteral drugs exert their effects while circulating in the bloodstream.
a. Parenteral drugs bypass the first-pass effect.
Rationale: Drugs given by the parenteral route bypass the first-pass effect.
Reduced blood flow to the stomach and the presence of food in the stomach apply to enteral drugs (taken orally), not to parenteral drugs.
Parenteral drugs must be absorbed into cells and tissues from the circulation before they can exert their effects; they do not exert their effects while circulating in the bloodstream.
When monitoring the patient receiving an intravenous infusion to reduce blood pressure, the nurse notes that the patient’s blood pressure is extremely low, and the patient is lethargic and difficult to awaken. This would be classified as which type of adverse
drug reaction?
a. Adverse effect
b. Allergic reaction
c. Idiosyncratic reaction
d. Pharmacologic reaction
d. Pharmacologic reaction
Rationale: A pharmacologic reaction is an extension of a drug’s normal effects in the body. In this case, the antihypertensive drug lowered the patient’s blood pressure levels too much.
The other options do not describe a pharmacologic reaction. An adverse effect is a predictable, well-known adverse drug reaction that results in minor or no changes in patient management.
An allergic reaction (also known as a hypersensitivity reaction) involves the patient’s immune system.
An idiosyncratic reaction is unexpected and is defined
as a genetically determined abnormal response to normal dosages of a drug.
The nurse is reviewing pharmacology terms for a group of newly graduated nurses. Which sentence defines a drug’s half-life?
a. The time it takes for the drug to cause half of its therapeutic response
b. The time it takes for one-half of the original amount of a drug to reach the target cells
c. The time it takes for one-half of the original amount of a drug to be removed from the body
d. The time it takes for one half of the original amount of a drug to be absorbed into the circulation
c. The time it takes for one-half of the original amount of a drug to be removed from the body
Rationale: A drug’s half-life is the time it takes for one-half of the original amount of a drug to be removed from the body. It is a measure of the rate at which drugs are removed from the body. The other options are incorrect definitions of half-life.
When administering drugs, the nurse remembers that the duration of action of a drug is defined as which of these?
a. The time it takes for a drug to elicit a therapeutic response
b. The amount of time needed to remove a drug from circulation
c. The time it takes for a drug to achieve its maximum therapeutic response
d. The time period at which a drug’s concentration is sufficient to cause a therapeutic response
d. The time period at which a drug’s concentration is sufficient to cause a therapeutic response
Rationale: Duration of action is the time during which drug’s concentration is sufficient to elicit a therapeutic response.
The other options do not define duration of action. A drug’s onset of action is the time it takes for the drug to elicit a therapeutic response.
A drug’s peak effect is the time it takes for the drug to reach its maximum therapeutic response.
Elimination is the length of time it takes to remove a drug from circulation.
When reviewing the mechanism of action of a specific drug, the nurse reads that the drug works by selective enzyme interaction. Which of these processes describes selective enzyme interaction?
a. The drug alters cell membrane permeability.
b. The drug’s effectiveness within the cell walls of the target tissue is enhanced.
c. The drug is attracted to a receptor on the cell wall, preventing an enzyme from binding to that receptor.
d. The drug binds to an enzyme molecule and inhibits or enhances the enzyme’s action with the normal target cell.
d. The drug binds to an enzyme molecule and inhibits or enhances the enzyme’s action with the normal target cell.
Rationale: With selective enzyme interaction, the drug attracts the enzymes to bind with the drug instead of allowing the enzymes to bind with their normal target cells.
As a result, the target cells are protected from the action of the enzymes. This results in a drug effect.
The actions described in the other options do not occur with selective enzyme interactions.
When administering a new medication to a patient, the nurse reads that it is highly protein-bound. Assuming that the patient’s albumin levels are normal, the nurse would expect which result, as compared to a medication, that is not highly protein-bound?
a. Renal excretion will be faster.
b. The drug will be metabolized quickly.
c. The duration of action of the medication will be shorter.
d. The duration of action of the medication will be longer.
d. The duration of action of the medication will be longer.
Rationale: Drugs that are bound to plasma proteins are characterized by a longer duration of action. Protein binding does not make renal excretion faster, does not speed up drug metabolism, and does not cause the duration of action to be shorter.
The patient is experiencing chest pain and needs to take a sublingual form of nitroglycerin. Where does the nurse instruct the patient to place the tablet?
a. Under the tongue
b. On top of the tongue
c. At the back of the throat
d. In the space between the cheek and the gum
a. Under the tongue
Rationale: Drugs administered via the sublingual route are placed under the tongue. Drugs administered via the buccal route are placed in the space between the cheek and the gum; oral drugs are swallowed. The other options are incorrect.
The nurse is administering medications to the patient who is in renal failure resulting from end-stage renal disease. The nurse is aware that patients with kidney failure would most likely have problems with which pharmacokinetic phase?
a. Absorption
b. Distribution
c. Metabolism
d. Excretion
d. Excretion
Rationale: The kidneys are the organs that are most responsible for drug excretion. The renal function does not affect the absorption and distribution of a drug. Renal function may affect the metabolism of drugs to a small extent.
A patient who has advanced cancer is receiving opioid medications around the clock to keep him comfortable as he nears the end of his life. Which term best describes this type of therapy?
a. Palliative therapy
b. Maintenance therapy
c. Empiric therapy
d. Supplemental therapy
a. Palliative therapy
Rationale: The goal of palliative therapy is to make the patient as comfortable as possible.
It is typically used in the end stages of illnesses when all attempts at curative therapy have failed.
Maintenance therapy is used for the treatment of chronic illnesses such as hypertension.
Empiric therapy is based on clinical probabilities and involves drug administration when a certain pathologic
condition has an uncertain but high likelihood of occurrence based on the patient’s initial presenting symptoms.
Supplemental therapy (or replacement therapy) supplies the body with a substance needed to maintain normal function.
The patient is stating that he has a headache and asks the nurse which over-the-counter medication form would work the fastest to help reduce the pain. Which medication form will the nurse suggest?
a. A capsule
b. A tablet
c. An enteric-coated tablet
d. A powder
d. A powder
Rationale: Of the types of oral medications listed, the powder form would be absorbed the fastest, thus having a faster onset. The tablet, the capsule, and, finally, the enteric-coated tablet would be absorbed next, in that order.
The nurse will be injecting a drug into the superficial skin layers immediately underneath the epidermal layer of skin. Which route does this describe?
a. Intradermal
b. Subcutaneous
c. Intramuscular
d. Transdermal
a. Intradermal
Rationale: Injections under the more superficial skin layers immediately underneath the epidermal layer of skin and into the dermal layer are known as intradermal injections.
Injections into the fatty subcutaneous tissue under the dermal layer of skin are referred to as subcutaneous injections.
Injections into the muscle beneath the subcutaneous fatty tissue are referred to as intramuscular injections.
Transdermal drugs are applied to the skin via an adhesive patch.
Which drugs would be affected by the first-pass effect when administered? (Select all that apply.)
a. Morphine given by IV push injection
b. Sublingual nitroglycerin tablets
c. Diphenhydramine (Benadryl) elixirs
d. Levothyroxine (Synthroid) tablets
e. Transdermal nicotine patches
f. Esomeprazole (Nexium) capsules
g. Penicillin given by IV piggyback infusion
c. Diphenhydramine (Benadryl) elixirs
d. Levothyroxine (Synthroid) tablets
e. Transdermal nicotine patches
Rationale: Orally administered drugs (elixirs, tablets, and capsules) undergo the first-pass effect, because they are metabolized in the liver after being absorbed into the portal circulation from the small intestine.
IV medications (IV push and IV piggyback) enter the
bloodstream directly and do not go directly to the liver. Sublingual tablets and transdermal patches also enter the bloodstream without going directly to the liver, thus avoiding the first-pass effect.
Drug transfer to the fetus is more likely during the last trimester of pregnancy for which reason?
a. Decreased fetal surface area
b. Increased placental surface area
c. Enhanced blood flow to the fetus
d. Increased amount of protein-bound drug in maternal circulation
c. Enhanced blood flow to the fetus
Rationale: Drug transfer to the fetus is more likely during the last trimester of pregnancy as a result of enhanced blood flow to the fetus.
The other options are incorrect. Increased fetal surface area, not decreased, is a factor that affects drug transfer to the fetus.
The placenta’s surface area does not increase during this time. Drug transfer is increased because of an increased amount of free drugs, not protein-bound drugs, in the mother’s circulation.
The nurse is monitoring a patient who is in the 26th week of pregnancy and has developed gestational diabetes and pneumonia. She is given medications that pose a possible fetal risk, but the potential benefits may warrant the use of the medications in her
situation. The nurse recognizes that these medications are in which U.S. Food and Drug Administration pregnancy safety category?
a. Category X
b. Category B
c. Category C
d. Category D
d. Category D
Rationale: Pregnancy category D fits the description given.
Category B indicates no risk to animal fetus; information for humans is not available.
Category C indicates adverse effects reported in animal fetus; information for humans is not available.
Category X
consists of drugs that should not be used in pregnant women because of reports of fetal abnormalities and positive evidence of fetal risk in humans.
When discussing dosage calculation for pediatric patients with a clinical pharmacist, the nurse notes which type of dosage calculation is used most commonly in pediatric calculations?
a. West nomogram
b. Clark rule
c. Height-to-weight ratio
d. Milligram per kilogram of body weight formula
d. Milligram per kilogram of body weight formula
Rationale: The milligram per kilogram formula, based on body weight, is the most common method of calculating doses for pediatric patients.
The other options are available methods but are not the most commonly used. The height-to-weight ratio is not used.
The nurse is assessing a newly admitted 83-year-old patient and determines that the patient is experiencing polypharmacy. Which statement most accurately illustrates polypharmacy?
a. The patient is experiencing multiple illnesses.
b. The patient uses one medication for an illness several times per day.
c. The patient uses over-the-counter drugs for an illness.
d. The patient uses multiple medications simultaneously.
d. The patient uses multiple medications simultaneously.
Rationale: Polypharmacy usually occurs when a patient has several illnesses and takes medications for each of them, possibly prescribed by different specialists who may be unaware of other treatments the patient is undergoing.
The other options are incorrect.
Polypharmacy addresses the medications taken, not just the illnesses.
Polypharmacy means the patient is taking several different medications, not just one, and can include prescription drugs, over-the-counter medications, and herbal products.
The nurse is aware that confusion, forgetfulness, and increased risk for falls are common responses in an elderly patient who is taking which type of drug?
a. Laxatives
b. Anticoagulants
c. Sedatives
d. Antidepressants
c. Sedatives
Rationale: Sedatives and hypnotics often cause confusion, daytime sedation, ataxia, lethargy, forgetfulness, and increased risk for falls in the
elderly.
Laxatives, anticoagulants, and antidepressants may cause adverse effects in the elderly, but not the ones specified in the question.
For accurate medication administration to pediatric patients, the nurse must take into account which criteria?
a. Organ maturity
b. Renal output
c. Body temperature
d. Height
a. Organ maturity
Rationale: To administer medications to pediatric patients accurately, one must take into account organ maturity, body surface area, age, and weight.
The other options are incorrect; renal output and body temperature are not considerations, and height alone is not sufficient.
The nurse recognizes that an elderly patient may experience a reduction in the stomach’s ability to produce hydrochloric acid. This change may result in which effect?
a. Delayed gastric emptying
b. Increased gastric acidity
c. Decreased intestinal absorption of medications
d. Altered absorption of some drugs
d. Altered absorption of some drugs
Rationale: Reduction in the stomach’s ability to produce hydrochloric acid is an aging-related change that results in a decrease in gastric acidity and may alter the absorption of some drugs.
The other options are not results of reduced hydrochloric acid production.
The nurse is administering drugs to neonates and will consider which factor may contribute the most to drug toxicity?
a. The lungs are immature.
b. The kidneys are small.
c. The liver is not fully developed.
d. Excretion of the drug occurs quickly.
c. The liver is not fully developed.
Rationale: A neonate’s liver is not fully developed and cannot detoxify many drugs. The other options are incorrect. The lungs and kidneys do not play major roles in drug metabolism.
Renal excretion is slow, not fast, because of organ immaturity, but this is not the factor that contributes the most to drug toxicity.
An 83-year-old woman has been given a thiazide diuretic to treat heart failure. She and her daughter should be told to watch for which problems?
a. Constipation and anorexia
b. Fatigue, leg cramps, and dehydration
c. Daytime sedation and lethargy
d. Edema, nausea, and blurred vision
b. Fatigue, leg cramps, and dehydration
Rationale: Electrolyte imbalance, leg cramps, fatigue, and dehydration are common complications when thiazide diuretics are given to elderly
patients.
The other options do not describe complications that occur when these drugs are given to the elderly.
An elderly patient with a new diagnosis of hypertension will be receiving a new prescription for an antihypertensive drug. The nurse expects which type of dosing to occur with this drug therapy?
a. Drug therapy will be based on the patient’s weight.
b. Drug therapy will be based on the patient’s age.
c. The patient will receive the maximum dose that is expected to reduce the blood pressure.
d. The patient will receive the lowest possible dose at first, and then the dose will be increased as needed.
d. The patient will receive the lowest possible dose at first, and then the dose will be increased as needed.
Rationale: As a general rule, dosing for elderly patients should follow the admonition, “Start low, and go slow,” which means to start with the lowest possible dose (often less than an average adult dose) and increase the dose slowly, if needed, based on patient response. The
other responses are incorrect.
The nurse is trying to give a liquid medication to a 2 1
2 -year-old child and notes that the medication has a strong taste. Which technique is the best way for the nurse to give the medication to this child?
a. Give the medication with a spoonful of ice cream.
b. Add the medication to the child’s bottle.
c. Tell the child you have candy for him.
d. Add the medication to a cup of milk.
a. Give the medication with a spoonful of ice cream.
Rationale: Ice cream or another nonessential food disguises the taste of the medication. The other options are incorrect.
If the child does not drink the entire contents of the bottle, medication is wasted and the full dose is not administered.
Using the word candy with drugs may lead to the child thinking that drugs are actually candy.
If the medication is mixed with a cup of milk, the child may not drink the entire cup of milk, and the distasteful drug may cause the child to refuse milk in the future.
The nurse is preparing to give an injection to a 4-year-old child. Which intervention is age-appropriate for this child?
a. Give the injection without any advanced preparation.
b. Give the injection, and then explain the reason for the procedure afterward.
c. Offer a brief, concrete explanation of the procedure at the patient’s level and with the parent or caregiver present.
d. Prepare the child in advance with details about the procedure without the parent or caregiver present.
c. Offer a brief, concrete explanation of the procedure at the patient’s level and with the parent or caregiver present.
Rationale: For a 4-year-old child, offering a brief, concrete explanation about a procedure just beforehand, with the parent or caregiver present, is appropriate. The other options are incorrect for any age group.
Which statements are true regarding pediatric patients and pharmacokinetics? (Select all that apply.)
a. The levels of microsomal enzymes are decreased.
b. Perfusion to the kidneys may be decreased and may result in reduced renal function.
c. First-pass elimination is increased because of higher portal circulation.
d. First-pass elimination is reduced because of the immaturity of the liver.
e. Total body water content is much less than in adults.
f. Gastric emptying is slowed because of slow or irregular peristalsis.
g. Gastric emptying is more rapid because of increased peristaltic activity.
a. The levels of microsomal enzymes are decreased.
b. Perfusion to the kidneys may be decreased and may result in reduced renal function.
d. First-pass elimination is reduced because of the immaturity of the liver.
f. Gastric emptying is slowed because of slow or irregular peristalsis.
Rationale: In children, first-pass elimination by the liver is reduced because of the immaturity of the liver, and microsomal enzymes are decreased. In addition, gastric emptying is reduced because of slow or irregular peristalsis.
Perfusion to the kidneys may be decreased, resulting in reduced renal function. The other options are incorrect. In addition, remember that total body water content is greater in children than in adults.
Which statements are true regarding the elderly and pharmacokinetics? (Select all that apply.)
a. The levels of microsomal enzymes are decreased.
b. Fat content is increased because of decreased lean body mass.
c. Fat content is decreased because of increased lean body mass.
d. The number of intact nephrons is increased.
e. The number of intact nephrons is decreased.
f. Gastric pH is less acidic.
g. Gastric pH is more acidic.
a. The levels of microsomal enzymes are decreased.
b. Fat content is increased because of decreased lean body mass.
e. The number of intact nephrons is decreased.
f. Gastric pH is less acidic.
Rationale: In the elderly, levels of microsomal enzymes are decreased because the aging liver is less able to produce them; fat content is increased because of decreased lean body mass; the number of intact nephrons is decreased as the result of aging; and gastric pH is less acidic because of a gradual reduction of the production of hydrochloric acid. The other options are incorrect statements.
During the development of a new drug, which would be included in the study by the researcher to prevent any bias or unrealistic expectations of the new drug’s usefulness?
a. A placebo
b. FDA approval
c. Informed consent
d. Safety information
a. A placebo
Rationale: To prevent bias that may occur as a result of unrealistic expectations of an investigational new drug, a placebo is incorporated into the study. The other options are incorrect.
FDA approval, if given, does not occur until after phase III. Informed consent is required in all drug studies. Safety information is not determined until the study is underway.
A member of an investigational drug study team is working with healthy volunteers whose participation will help to determine the optimal dosage range and pharmacokinetics of the drug. The team member is participating in what type of study?
a. Phase I
b. Phase II
c. Phase III
d. Phase IV
a. Phase I
Rationale: Phase I studies involve small numbers of healthy volunteers to determine optimal dosage range and the pharmacokinetics of the drug.
The other phases progressively involve volunteers who have the disease or ailment that the drug is designed to diagnose or treat.
During discharge patient teaching, the nurse reviews prescriptions with a patient. Which statement is correct about refills for an analgesic that is classified as Schedule C-III?
a. No prescription refills are permitted.
b. Refills are allowed only by written prescription.
c. The patient may have no more than five refills in a 6-month period.
d. Written prescriptions expire in 12 months.
c. The patient may have no more than five refills in a 6-month period.
Rationale: Schedule C-III medications may be refilled no more than five times in a 6-month period.
The patient should be informed of this regulation. No prescription refills are permitted for Schedule C-II drugs.
Requiring refills by written prescription only applies to
Schedule C-II drugs.
Schedule C-III prescriptions (written or oral) expire in 6 months.
A patient has been selected as a potential recipient of an experimental drug for heart failure. The nurse knows that when informed consent has been obtained, it indicates which of these?
a. The patient has been informed that he or she will need to stay in the study until it ends.
b. The patient will be informed of the details of the study as the research continues.
c. The patient will receive the actual drug during the experiment.
d. The patient has had the study’s purpose, procedures, and possible benefits, as well
as risks involved, explained to him.
d. The patient has had the study’s purpose, procedures, and possible benefits, as well as risks involved, explained to him.
Rationale: Informed consent involves the careful explanation of the purpose of the study, the procedures to be used, and the risks involved.
The other options do not describe informed consent. Participation in studies is voluntary and patients have the right to end participation at any time.
For which cultural group must the health care provider respect the value placed on preserving harmony with nature and the belief that disease is a result of ill spirits?
a. Hispanics
b. Asian Americans
c. Native Americans
d. African Americans
c. Native Americans
Rationale: Some Native Americans believe in preserving harmony with nature and that disease is a result of ill spirits. The groups listed in the other options do not typically reflect these practices.
The nurse is assessing an elderly Hispanic woman who is being treated for hypertension. During the assessment, what is important for the nurse to remember about cultural aspects?
a. The patient should be discouraged from using folk remedies and rituals.
b. The nurse will expect the patient to value protective bracelets and “root doctors” as healers.
c. The nurse will remember that the balance among body, mind, and environment is important for this patient’s health beliefs.
d. The nurse’s assessment needs to include gathering information regarding religious practices and beliefs regarding medication, treatment, and healing.
d. The nurse’s assessment needs to include gathering information regarding religious practices and beliefs regarding medication, treatment, and healing.
Rationale: All beliefs need to be considered clearly so as to prevent a conflict from arising between the goals of nursing and health care and the dictates of a patient’s cultural background.
Assessing religious practices and beliefs is part of a thorough cultural assessment.
The other options are incorrect.
The nurse should not ignore a patient’s cultural practices.
The concept of balance among body, mind, and environment and the valuing of protective bracelets and root doctors reflect beliefs or practices that usually do not apply to the Hispanic cultural group.
When reviewing the various schedules of controlled drugs, the nurse knows which description correctly describes Schedule II drugs?
a. Drugs with high potential for abuse that have accepted medical use
b. Drugs with high potential for abuse that do not have accepted medical use
c. Medically accepted drugs that may cause moderate physical or psychologic dependence
d. Medically accepted drugs with limited potential for causing physical or psychological dependence
a. Drugs with high potential for abuse that have accepted medical use
Rationale: Schedule II drugs are those with high potential for abuse but that have accepted medical use.
Drugs that have a high potential for abuse but do not have accepted medical use are Schedule I drugs. Medically accepted drugs that have moderate physical or high psychologic dependence potential are Schedule III drugs.
Medically accepted drugs with limited potential for causing physical or psychological dependence are Schedule IV and V drugs.
The nurse is reviewing facts about pharmacology for a review course. The term legend drug refers to which item?
a. Over-the-counter drugs
b. Prescription drugs
c. Orphan drugs
d. Older drugs
b. Prescription drugs
Rationale: The term legend drug refers to prescription drugs, which were differentiated from over-the-counter drugs by the 1951 Durham-Humphrey Amendment. Orphan drugs are drugs that are developed for rare diseases. The other options are not examples
of legend drugs.
Nurses have the ethical responsibility to tell the truth to their patients. What is this principle known as?
a. Justice
b. Veracity
c. Beneficence
d. Autonomy
b. Veracity
Rationale: Veracity is defined as the duty to tell the truth. Justice is the ethical principle of being fair or equal in one’s actions.
Beneficence is the ethical principle of doing or actively promoting good. Autonomy is self-determination, or the ability to make one’s own decisions
A patient is undergoing major surgery and asks the nurse about a living will. He states, “I don’t want anybody else making decisions for me. And I don’t want to prolong my life.” The patient is demonstrating which ethical term?
a. Autonomy
b. Beneficence
c. Justice
d. Veracity
a. Autonomy
Rationale: Autonomy includes self-determination, or the ability to act on one’s own, including making one’s own decisions about health care.
Veracity is defined as the duty to tell the truth.
Justice is the ethical principle of being fair or equal in one’s actions.
Beneficence is the ethical principle of doing or actively promoting good.
The nurse is reviewing a list of scheduled drugs and notes that Schedule C-I drugs are not on the list. Which is a characteristic of Schedule C-I drugs?
a. No refills are permitted.
b. They may be obtained over-the-counter with a signature.
c. They are available only by written prescription.
d. They are used only with approved protocols.
d. They are used only with approved protocols.
Rationale: Schedule C-I drugs are used only with approved protocols.
Schedule C-II drugs are available only by written prescription, and refills are not permitted.
Being available over-the-counter with a signature may be true of Schedule C-V drugs in certain states.
During a busy night shift, a new nurse administered an unfamiliar medication without checking it in a drug handbook. Later that day, the patient had a severe reaction because he has renal problems, which was a contraindication to that drug. The nurse maybe
liable for which of these?
a. Medical negligence
b. Nursing negligence
c. Nonmaleficence
d. Autonomy
b. Nursing negligence
Rationale: Negligence is the failure to act in a reasonable and prudent manner or failure of the nurse to give the care that a reasonably prudent
(cautious) nurse would render or use under similar circumstances.
Nurses are expected to assess patients thoroughly before medications are given, and to be familiar with medications they are administering (see Box 4-2). In this case, nursing negligence applies to nurses, not medical negligence.
Nonmaleficence is defined as the duty to do no harm; autonomy is defined as the right to
make one’s own decisions or self-determination.
The nurse is reviewing the concept of drug polymorphism. Which factors contribute to drug polymorphism? (Select all that apply.)
a. The number of drugs ordered by the physician
b. Inherited factors
c. The patient’s diet and nutritional status
d. Different dosage forms of the same drug
e. The patient’s cultural practices
f. The patient’s drug history
g. The various available forms of a drug
b. Inherited factors
c. The patient’s diet and nutritional status
e. The patient’s cultural practices
Rationale: Inherited factors, diet and nutritional status, and cultural practices are some of the factors that contribute to drug polymorphism.
The other options are not factors that contribute to drug polymorphism.
The nurse is performing an admission assessment. Which findings reflect components of a cultural assessment? (Select all that apply.)
a. The patient uses aspirin as needed for pain.
b. The patient has a history of hypertension.
c. The patient uses herbal tea to relax in the evenings.
d. The patient does not speak English.
e. The patient is allergic to shellfish.
f. The patient does not eat pork products because of religious beliefs.
a. The patient uses aspirin as needed for pain.
c. The patient uses herbal tea to relax in the evenings.
d. The patient does not speak English.
f. The patient does not eat pork products because of religious beliefs.
Rationale: The past use of medicines, use of herbal treatments, languages spoken, and religious practices and beliefs are components of a cultural assessment. The other options reflect components of a general medication assessment or health history.
What is the study of physiochemical properties of drugs and how they influence the body called?
A. Pharmaceutics
B. Pharmacokinetics
C. Pharmacodynamics
D. Pharmacotherapeutics
C. Pharmacodynamics
Rationale: In simple terms, pharmacodynamics is the study of what drugs do to the body.
A patient asks the nurse the difference between a generic drug and a trade or brand-name drug. Which of the following are true regarding generic drugs? (Select all that apply)
A. Have less potential for abuse and dependence
B. Have the same chemical composition as the brand-name drug
C. May have several brand names
D. May have several generic names
E. Are usually less expensive than a brand-name drug
B. Have the same chemical composition as the brand-name drug
C. May have several brand names
E. Are usually less expensive than a brand-name drug
Patients with renal failure would most likely have problems with drug
A. excretion.
B. absorption.
C. metabolism.
D. distribution.
A. excretion.
Rationale: The kidneys are responsible for the majority of drug excretion
A staff educator is preparing an in-service to review factors that influence medication metabolism. Which of the following would the educator include as a reason to administer a lower medication dosage? (Select all that apply)
A. Increased renal excretion
B. Increased medication-metabolizing enzymes
C. Liver failure
D. Peripheral vascular disease
E. Concurrent use of medication with the same pathway of metabolism
C. Liver failure
E. Concurrent use of medication with the same pathway of metabolism
Rationale:
(c)- liver failure decreases metabolism and increased the concentration of this med.
(e)- when the same pathway metabolizes two meds, they compete for metabolism.
A patient asks the nurse why a lower dose of IV pain medication is being given than the previous oral dose. What is the nurse’s best response to the patient?
A. “Medications are given orally bypass the portal circulatory system.”
B. “Medications given intravenously are not affected by the first-pass effect.”
C. “Drugs administered intravenously enter the portal system before systemic distribution.”
D. “A large percentage of an intravenously administered drug is metabolized into inactive metabolites in the liver.”
B. “Medications given intravenously are not affected by the first-pass effect.”
Rationale: When drugs with a high first-pass effect are administered orally, a large amount of drug may be metabolized before it reaches the systemic circulation. The same drug given intravenously will bypass the liver.
This prevents the first-pass effect from taking place, and therefore more of the drug reaches the circulation. Parenteral doses of drugs with a high first-pass effect are much smaller than oral doses, yet they produce the same pharmacologic response.
A patient is prescribed ibuprofen 200 mg PO every 4 hours as needed for pain. The pharmacy sends up enteric-coated tablets, but the patient refuses the tablets, stating that she cannot swallow pills. What will the nurse do?
A. Crush the tablets and mix them with applesauce or pudding.
B. Call the pharmacy and ask for the liquid form of the
medication.
C. Call the pharmacy and ask for the IV form of the medication
D. Encourage the patient to try to swallow the tablets
B. Call the pharmacy and ask for the liquid form of the
medication.
Rationale: The liquid form is appropriate because it is also given via the oral route. Enteric-coated tablets should not be crushed, and the patient should not be forced to take the tablets.
This medication does not have an IV form, but even if it did, the routes cannot be changed without a health care provider’s order.
When teaching a pregnant woman about the use of drugs during pregnancy, which statement will the nurse include?
A. Exposure of the fetus to drugs is most detrimental during the second trimester of pregnancy.
B. Pregnant women must never take drugs to control high blood pressure.
C. Drug transfer to a fetus is most likely to occur during the last trimester of pregnancy.
D. A fetus is at greatest risk for drug-induced developmental defects during the second trimester of pregnancy.
C. Drug transfer to a fetus is most likely to occur during the last trimester of pregnancy.
Rationale: Drug transfer to the fetus is most likely to occur during the last trimester of pregnancy.
Exposure of a fetus to drugs is most detrimental during the first trimester of pregnancy, and fetuses are at greatest risk for drug-induced developmental defects during the first trimester of pregnancy.
Pregnant women need to take medications to control situations such as high blood pressure.
When administering medications to pediatric patients, the nurse understands that the dosage calculations for pediatric patients are different than for adults because pediatric patients
A. are more likely to develop edema.
B. have more stomach acid.
C. have skin that is less permeable.
D. have immature liver and kidney function
D. have immature liver and kidney function
Rationale: In pediatric patients, body temperature is less well regulated, and dehydration occurs easily; pediatric patients lack stomach acid to kill bacteria and have skin that is thinner and more permeable.
It is true that pediatric patients have immature liver and kidney function, resulting in impaired drug metabolism and excretion.