NSCs and Adult Neurogenesis Flashcards
totipotent vs pluripotent vs multipotent
totipotent - generate every cell type in embryo and placenta
pluripotent - generate every cell type in embryo
multipotent - generate multiple specialised cell types in a tissue
population studies of stem cells
immunohistochemisty
single cell RNA-sequencing
thymidine analogues
clonal analysis
lineage tracing
genetic or viral mediated labelling most common
neurogenesis in SVZ
NSCs are Type B cells. They generate Type C cells which are neural progenitor cells. TC generate TA cells which are neuroblasts, that migrate through RMS to olfactory bulb
differentiate into different types of interneurons
neurogenesis in hippocampus
dentate gyrus
NSCs are radial glial-like cells, multipotent and usually quiescent
only granule cells are generated