developing pain Flashcards

1
Q

sensory fibres

A

A-beta : large myelinated; touch, pressure & vibration

A-delta: small myelinated; cold, fast pain, sharp

C: unmyelinated; warmth, slow pain, dull, diffuse

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

peripheral sentisisatoin

A

chemical mediators - macrophages, neutrophils, mast cells - release chemicals - PGE2, bradykinin, adrenaline which stimulate different receptors on nociceptive terminal , allow ions to move into nerve
also NGF binds to TrkA and stimulates expression of new receptors

threshold for depot lowered - small stimulus will result in activation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly