NSAIDs & Chondroprotective Agents Flashcards
To minimize potential side effect of nonsteroidal anti-inflammatory medicines-induced gastric ulceration, misoprostol is used:
As a prostaglandin analogue to reduce acid secretion and to strengthen gastric mucosal barrier.
During anaesthesia in dogs, which of the following nonsteroidal anti-inflammatory medicines had been observed to affect the function of the kidney, resulting in decreased creatinine clearance?
Carprofen
The following medicines can be used for prevention of potential GI side effects associated with the use of nonsteroidal anti-inflammatory medicines except:
Sucralfate
Which of the following is most correct regarding nonsteroidal anti-inflammatory medicines that are selective COX-2 inhibitors?
May cause less gastric ulceration than other other nonsteroidal anti-inflammatory medicines.
Of the alternatives below, which one best describes nonsteroidal anti-inflammatory medicines in order of increasing selectivity for inhibition of COX 2 enzyme?
Meloxicam, robenacoxib, firocoxib.
Of the following nonsteroidal anti-inflammatory medicines, which one is most likely to cause hepatotoxicity in Labradors?
Carprofen
Of the following nonsteroidal anti-inflammatory medicines, which one would be the best alternative to reduce cat’s body temperature in case meloxicam is not effective?
Ketoprofen
About the pharmacokinetics of nonsteroidal anti-inflammatory medicines, which of the following statements is not correct?
They are weak organic bases
Which of the following organs or systems is most likely to be affected in case of paracetamol’s toxicity in cats?
The liver
Regarding therapy for paracetamol’s toxicosis in cats, which of the followings is not correct?
Cimetidine may be used to inhibit cytochrome P450 enzymes’ mediated metabolism of the medicine in the liver.
In case of paracetamol’s toxicity in cats, N acetylcysteine may aid in the elimination of the medicine. Which of the following best describes how the N acetylcysteine works to reduce toxicity?
It acts to maintain or replenish depleted glutathione reserves, reducing formation of toxic metabolite.
Of the following nonsteroidal anti-inflammatory medicines, which one is the most selective COX 2 enzyme inhibitors?
Firocoxib
Of the following medicines is a proton pump inhibitor?
Omeprazole
Which of the following statements about chondroprotective agents is not correct?
Synvisc contains polysulphated glycosaminoglycans.
The following statements are correct about combination of chondroitin sulphate and glucosamine, except:
The combination has no anti-inflammatory effect.
